Topical aqueous extract of Ephedra alata can improve wound healing in an animal model
Purpose: Ephedra alata (E. alata) is perennial tough shrub plant that grows in Palestine and other regions. It is used often in folk's medicine for the treatment of various diseases. In this project, E. alata extract was tested for its ability to improve wound and burn healing. Methods: An aque...
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2017-04-01
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| Series: | Chinese Journal of Traumatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1008127516302115 |
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doaj-99ebd51cc6ad4b2fb4e719747ff078782020-11-24T21:08:09ZengElsevierChinese Journal of Traumatology1008-12752017-04-0120210811310.1016/j.cjtee.2016.10.004Topical aqueous extract of Ephedra alata can improve wound healing in an animal modelNaim Kittana0Hanood Abu-Rass1Ruba Sabra2Lama Manasra3Hadeel Hanany4Nidal Jaradat5Fatima Hussein6Abdel Naser Zaid7Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, An-Najah National University, Nablus – P.O. Box 7, PalestineDepartment of Biomedical Sciences, Faculty of Medicine & Health Sciences, An-Najah National University, Nablus – P.O. Box 7, PalestineDepartment of Pharmacy, Faculty of Medicine & Health Sciences, An-Najah National University, Nablus – P.O. Box 7, PalestineDepartment of Pharmacy, Faculty of Medicine & Health Sciences, An-Najah National University, Nablus – P.O. Box 7, PalestineDepartment of Pharmacy, Faculty of Medicine & Health Sciences, An-Najah National University, Nablus – P.O. Box 7, PalestineDepartment of Pharmacy, Faculty of Medicine & Health Sciences, An-Najah National University, Nablus – P.O. Box 7, PalestineDepartment of Pharmacy, Faculty of Medicine & Health Sciences, An-Najah National University, Nablus – P.O. Box 7, PalestineDepartment of Pharmacy, Faculty of Medicine & Health Sciences, An-Najah National University, Nablus – P.O. Box 7, PalestinePurpose: Ephedra alata (E. alata) is perennial tough shrub plant that grows in Palestine and other regions. It is used often in folk's medicine for the treatment of various diseases. In this project, E. alata extract was tested for its ability to improve wound and burn healing. Methods: An aqueous extract of E. alata was prepared and underwent several phytochemical analyses for the presence of the major classes of phytochemical compounds. After that, a polyethylene glycol-based ointment containing the extract of E. alata was prepared and its wound and burn healing activities were tested in-vivo using an animal model for deep wound and full thickness skin burn. The effect was compared against a placebo ointment. Skin biopsies were evaluated by a blinded clinical histopathologist, in addition to digital analysis. Results: Phytochemical analysis demonstrated the presence of the major classes of phytochemical compounds in the prepared extract including flavonoids, alkaloids, phytosteroids, phenolic compounds, volatile oils and tannins. As compared to placebo ointment, E. alata ointment significantly improved the healing of the wound ulcers, whereas it showed no advantage on the quality of the healing of burn ulcers. Conclusion: E. alata extract is rich in phytochemical compounds and can improve wound healing when applied topically.http://www.sciencedirect.com/science/article/pii/S1008127516302115Ephedra alataUlcerWound healingBurnsPhytochemicals |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Naim Kittana Hanood Abu-Rass Ruba Sabra Lama Manasra Hadeel Hanany Nidal Jaradat Fatima Hussein Abdel Naser Zaid |
| spellingShingle |
Naim Kittana Hanood Abu-Rass Ruba Sabra Lama Manasra Hadeel Hanany Nidal Jaradat Fatima Hussein Abdel Naser Zaid Topical aqueous extract of Ephedra alata can improve wound healing in an animal model Chinese Journal of Traumatology Ephedra alata Ulcer Wound healing Burns Phytochemicals |
| author_facet |
Naim Kittana Hanood Abu-Rass Ruba Sabra Lama Manasra Hadeel Hanany Nidal Jaradat Fatima Hussein Abdel Naser Zaid |
| author_sort |
Naim Kittana |
| title |
Topical aqueous extract of Ephedra alata can improve wound healing in an animal model |
| title_short |
Topical aqueous extract of Ephedra alata can improve wound healing in an animal model |
| title_full |
Topical aqueous extract of Ephedra alata can improve wound healing in an animal model |
| title_fullStr |
Topical aqueous extract of Ephedra alata can improve wound healing in an animal model |
| title_full_unstemmed |
Topical aqueous extract of Ephedra alata can improve wound healing in an animal model |
| title_sort |
topical aqueous extract of ephedra alata can improve wound healing in an animal model |
| publisher |
Elsevier |
| series |
Chinese Journal of Traumatology |
| issn |
1008-1275 |
| publishDate |
2017-04-01 |
| description |
Purpose: Ephedra alata (E. alata) is perennial tough shrub plant that grows in Palestine and other regions. It is used often in folk's medicine for the treatment of various diseases. In this project, E. alata extract was tested for its ability to improve wound and burn healing.
Methods: An aqueous extract of E. alata was prepared and underwent several phytochemical analyses for the presence of the major classes of phytochemical compounds. After that, a polyethylene glycol-based ointment containing the extract of E. alata was prepared and its wound and burn healing activities were tested in-vivo using an animal model for deep wound and full thickness skin burn. The effect was compared against a placebo ointment. Skin biopsies were evaluated by a blinded clinical histopathologist, in addition to digital analysis.
Results: Phytochemical analysis demonstrated the presence of the major classes of phytochemical compounds in the prepared extract including flavonoids, alkaloids, phytosteroids, phenolic compounds, volatile oils and tannins. As compared to placebo ointment, E. alata ointment significantly improved the healing of the wound ulcers, whereas it showed no advantage on the quality of the healing of burn ulcers.
Conclusion: E. alata extract is rich in phytochemical compounds and can improve wound healing when applied topically. |
| topic |
Ephedra alata Ulcer Wound healing Burns Phytochemicals |
| url |
http://www.sciencedirect.com/science/article/pii/S1008127516302115 |
| work_keys_str_mv |
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