Preparation of a number of heterocyclic compounds derived from benzotrazole

• Main Authors: Mohamed Mohamed, Ahmed Ahmed
• Format: Article
• Language: Arabic
• Published: College of Education for Pure Sciences 2013-12-01
• Series: مجلة التربية والعلم
• Subjects: preparation; heterocyclic compounds; benzotrazole
• Online Access: https://edusj.mosuljournals.com/article_163097_859eaafb4f6d6a7a9d4d1fb26cdfb3fd.pdf
• ISSN: 1812-125X; 2664-2530

<strong>ABSTRACT</strong><br />        In this thesis, a number of heterocyclic compounds with  five-memberd  , such as substituted oxadiazole  , thiadiazole , pyrazole , iso andoline-1,3-dione , also the preparation of  pyrroline and pyrrolidine compounds .<br />      The  ester  compound  (1) was  synthesized  from  the  reaction  of benzotriazole with ethyl chloroacetate. The hydrazide (2) was  prepared from the reaction of  ester (1)  with  hydrazine  hydrate , 1,3,4- Oxadiazole-5-thiol (3) was synthesized from the reaction of  hydrazide (2) with carbon disulfide in potassium hydroxide , 2,5-disubstituted 1,3,4-oxadiazole (4) compounds was prepared by reaction of ester (1) with hydrazide (2) in presence phosphorus oxychloride , while treatment of the hydrazides with substituted benzoic acid (4-chloro and 2-nitro) in the presence of phosphorous oxachloride gave disubstituted 1,3,4-oxadiazole (5,6) , Pyrazolone (7) was synthesized from the reaction of hydrazide (2) with methyl acetoacetate , The pyrazole (8) was synthesized from the reaction of hydrazide (2) with acetyl acetone , 2-(benzotriazolyle acetamido) iso andoline-1,3-dione (9) compounds was prepared by reaction of  hydrazide  (2) with phthalic anhydride , pyrroline-2,5-dione (10) was prepared from the reaction of hydrazide (2) with malic anhydride , pyrrolidine-2,5-dione (11) was prepared from the reaction of  hydrazide (2) with succinic anhydride , 2-Amino-1,3,4-thiadiazole (13) was prepared from the reaction of acid (12) with thiosemicarbazide in phosphorus oxychloride , Physical and available spectral were used to confirm structures .