Sex modifies the association between the CLOCK variant rs1801260 and BMI in school-age children.
Disruption of circadian rhythms and variations in the FTO gene may interfere with energy homeostasis and play a role in the development of obesity. The current study assessed the association of common polymorphisms in the CLOCK and FTO genes with standardized body mass index scores (BMI z-scores) an...
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doaj-99ee0f30ad9749a2a6e70c4ea34d00532021-03-03T22:01:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01158e023699110.1371/journal.pone.0236991Sex modifies the association between the CLOCK variant rs1801260 and BMI in school-age children.Ying MengBarbara LohseLeslie Cunningham-SaboDisruption of circadian rhythms and variations in the FTO gene may interfere with energy homeostasis and play a role in the development of obesity. The current study assessed the association of common polymorphisms in the CLOCK and FTO genes with standardized body mass index scores (BMI z-scores) and their potential modification of the impact of a culinary nutrition and physical activity intervention in school-age children. Anthropometric measurements were collected in 121 children at the baseline and one-year follow-up of a controlled trial of a school-based culinary nutrition and physical activity intervention. Genotypes of the CLOCK polymorphism (rs1801260) and the FTO polymorphism (rs9939609) were obtained from buccal swabs. Linear mixed-effects regression was applied to evaluate the genetic association and adjust for clusters within families and schools. In our participants, obesity affected 6.6% (8/121) of the children at the baseline and 6.4% (7/109) of the children at the follow-up. The associations between the age- and sex-adjusted BMI z-scores and the two polymorphisms did not reach statistically significance. Yet, sex potentially modified the association between rs1801260 and BMI z-scores. In girls, the G allele carriers had a higher BMI z-scores at the baseline and the follow-up. These polymorphisms did not modify the effect of our culinary nutrition and physical activity intervention on BMI z-scores. Sex is a potential modifier for the association between the CLOCK polymorphism, rs1801260, and BMI z-scores in school-age children. Further investigation is warranted to delineate the sex-dependent role of the CLOCK polymorphisms in the development of childhood obesity.https://doi.org/10.1371/journal.pone.0236991 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ying Meng Barbara Lohse Leslie Cunningham-Sabo |
spellingShingle |
Ying Meng Barbara Lohse Leslie Cunningham-Sabo Sex modifies the association between the CLOCK variant rs1801260 and BMI in school-age children. PLoS ONE |
author_facet |
Ying Meng Barbara Lohse Leslie Cunningham-Sabo |
author_sort |
Ying Meng |
title |
Sex modifies the association between the CLOCK variant rs1801260 and BMI in school-age children. |
title_short |
Sex modifies the association between the CLOCK variant rs1801260 and BMI in school-age children. |
title_full |
Sex modifies the association between the CLOCK variant rs1801260 and BMI in school-age children. |
title_fullStr |
Sex modifies the association between the CLOCK variant rs1801260 and BMI in school-age children. |
title_full_unstemmed |
Sex modifies the association between the CLOCK variant rs1801260 and BMI in school-age children. |
title_sort |
sex modifies the association between the clock variant rs1801260 and bmi in school-age children. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2020-01-01 |
description |
Disruption of circadian rhythms and variations in the FTO gene may interfere with energy homeostasis and play a role in the development of obesity. The current study assessed the association of common polymorphisms in the CLOCK and FTO genes with standardized body mass index scores (BMI z-scores) and their potential modification of the impact of a culinary nutrition and physical activity intervention in school-age children. Anthropometric measurements were collected in 121 children at the baseline and one-year follow-up of a controlled trial of a school-based culinary nutrition and physical activity intervention. Genotypes of the CLOCK polymorphism (rs1801260) and the FTO polymorphism (rs9939609) were obtained from buccal swabs. Linear mixed-effects regression was applied to evaluate the genetic association and adjust for clusters within families and schools. In our participants, obesity affected 6.6% (8/121) of the children at the baseline and 6.4% (7/109) of the children at the follow-up. The associations between the age- and sex-adjusted BMI z-scores and the two polymorphisms did not reach statistically significance. Yet, sex potentially modified the association between rs1801260 and BMI z-scores. In girls, the G allele carriers had a higher BMI z-scores at the baseline and the follow-up. These polymorphisms did not modify the effect of our culinary nutrition and physical activity intervention on BMI z-scores. Sex is a potential modifier for the association between the CLOCK polymorphism, rs1801260, and BMI z-scores in school-age children. Further investigation is warranted to delineate the sex-dependent role of the CLOCK polymorphisms in the development of childhood obesity. |
url |
https://doi.org/10.1371/journal.pone.0236991 |
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