The Role of Inflammasome Activation in Early HIV Infection

The Role of Inflammasome Activation in Early HIV Infection

The inflammasome pathway is an important arm of the innate immune system that provides antiviral immunity against many viruses. The main pathways involved in virus infections include the NLRP3, IFI16, and AIM2 pathways. However, a succinct understanding of its role in HIV is not yet well elucidated....

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Main Authors: Cyril Jabea Ekabe, Njinju Asaba Clinton, Jules Kehbila, Ngangom Chouamo Franck
Format: Article
Language:English
Published: Hindawi Limited 2021-01-01
Series:Journal of Immunology Research
Online Access:http://dx.doi.org/10.1155/2021/1487287
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spelling doaj-9a02fbd439764f339ecebb7104f5cf442021-10-04T01:58:37ZengHindawi LimitedJournal of Immunology Research2314-71562021-01-01202110.1155/2021/1487287The Role of Inflammasome Activation in Early HIV InfectionCyril Jabea Ekabe0Njinju Asaba Clinton1Jules Kehbila2Ngangom Chouamo Franck3Grace Community Health and Development AssociationGrace Community Health and Development AssociationGrace Community Health and Development AssociationFaculty of Health SciencesThe inflammasome pathway is an important arm of the innate immune system that provides antiviral immunity against many viruses. The main pathways involved in virus infections include the NLRP3, IFI16, and AIM2 pathways. However, a succinct understanding of its role in HIV is not yet well elucidated. In this review, we showed that NLRP3 inflammasome activation plays a vital role in inhibiting HIV entry into target cells via the purinergic pathway; IFI16 detects intracellular HIV ssDNA, triggers interferon I and III production, and inhibits HIV transcription; and AIM2 binds to HIV dsDNA and triggers acute inflammation and pyroptosis. Remarkably, by understanding these mechanisms, new therapeutic strategies can be developed against the disease.http://dx.doi.org/10.1155/2021/1487287
collection DOAJ
language English
format Article
sources DOAJ
author Cyril Jabea Ekabe
Njinju Asaba Clinton
Jules Kehbila
Ngangom Chouamo Franck
spellingShingle Cyril Jabea Ekabe
Njinju Asaba Clinton
Jules Kehbila
Ngangom Chouamo Franck
The Role of Inflammasome Activation in Early HIV Infection
Journal of Immunology Research
author_facet Cyril Jabea Ekabe
Njinju Asaba Clinton
Jules Kehbila
Ngangom Chouamo Franck
author_sort Cyril Jabea Ekabe
title The Role of Inflammasome Activation in Early HIV Infection
title_short The Role of Inflammasome Activation in Early HIV Infection
title_full The Role of Inflammasome Activation in Early HIV Infection
title_fullStr The Role of Inflammasome Activation in Early HIV Infection
title_full_unstemmed The Role of Inflammasome Activation in Early HIV Infection
title_sort role of inflammasome activation in early hiv infection
publisher Hindawi Limited
series Journal of Immunology Research
issn 2314-7156
publishDate 2021-01-01
description The inflammasome pathway is an important arm of the innate immune system that provides antiviral immunity against many viruses. The main pathways involved in virus infections include the NLRP3, IFI16, and AIM2 pathways. However, a succinct understanding of its role in HIV is not yet well elucidated. In this review, we showed that NLRP3 inflammasome activation plays a vital role in inhibiting HIV entry into target cells via the purinergic pathway; IFI16 detects intracellular HIV ssDNA, triggers interferon I and III production, and inhibits HIV transcription; and AIM2 binds to HIV dsDNA and triggers acute inflammation and pyroptosis. Remarkably, by understanding these mechanisms, new therapeutic strategies can be developed against the disease.
url http://dx.doi.org/10.1155/2021/1487287
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