Interactions between fatty acids and α-synuclein

α-Synuclein (αS) is an amyloidogenic neuronal protein associated with several neurodegenerative disorders. Although unstructured in solution, αS forms α-helices in the presence of negatively charged lipid surfaces. Moreover, αS was shown to interact with FAs in a manner that promotes protein aggrega...

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Bibliographic Details
Main Authors: Christian Luäcke, Donald L. Gantz, Elena Klimtchuk, James A. Hamilton
Format: Article
Language:English
Published: Elsevier 2006-08-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520331564