Counteracting incentive sensitization in severe alcohol dependence using deep brain stimulation of the nucleus accumbens: clinical and basic science aspects
The ventral striatum / nucleus accumbens has been implicated in the craving for drugs and alcohol which is a major reason for relapse of addicted people. Craving might be induced by drug-related cues. This suggests that disruption of craving-related neural activity in the nucleus accumbens may signi...
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doaj-9a0464d8f4d344929b3b82a2314176162020-11-25T03:46:32ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612009-09-01310.3389/neuro.09.022.2009710Counteracting incentive sensitization in severe alcohol dependence using deep brain stimulation of the nucleus accumbens: clinical and basic science aspectsHans-Jochen Heinze0Hans-Jochen Heinze1Marcus Heldmann2Marcus Heldmann3Jürgen Voges4Jürgen Voges5Hermann Hinrichs6Josep Marco-Pallares7Jens-Max Hopf8Jens-Max Hopf9Ulf Müller10Imke Galazky11Volker Sturm12Bernhard Bogerts13Thomas F Münte14Leibniz Institute of NeurobiologyUniversity of MagdeburgLeibniz Institute of NeurobiologyUniversity of MagdeburgUniversity of MagdeburgUniversity of MagdeburgUniversity of MagdeburgUniversity of MagdeburgLeibniz Institute of NeurobiologyUniversity of MagdeburgUniversity of MagdeburgUniversity of MagdeburgUniversity of CologneUniversity of MagdeburgUniversity of MagdeburgThe ventral striatum / nucleus accumbens has been implicated in the craving for drugs and alcohol which is a major reason for relapse of addicted people. Craving might be induced by drug-related cues. This suggests that disruption of craving-related neural activity in the nucleus accumbens may significantly reduce craving in alcohol-dependent patients. Here we report on preliminary clinical and neurophysiological evidence in three male patients who were treated with high frequency deep brain stimulation of the nucleus accumbens bilaterally. All three had been alcohol dependent for many years, unable to abstain from drinking, and had experienced repeated relapses prior to the stimulation. After the operation, craving was greatly reduced and all three patients were able to abstain from drinking for extended periods of time. Immediately after the operation but prior to connection of the stimulation electrodes to the stimulator, local field potentials were obtained from the externalized cables in two patients while they performed cognitive tasks addressing action monitoring and incentive salience of drug related cues. LFPs in the action monitoring task provided further evidence for a role of the nucleus accumbens in goal-directed behaviors. Importantly, alcohol related cue stimuli in the incentive salience task modulated LFPs even though these cues were presented outside of the attentional focus. This implies that cue-related craving involves the nucleus accumbens and is highly automatic.http://journal.frontiersin.org/Journal/10.3389/neuro.09.022.2009/fullNucleus AccumbensAddictionLocal Field Potentialsdeep brain stimulation (DBS)Action Monitoringreward processing |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hans-Jochen Heinze Hans-Jochen Heinze Marcus Heldmann Marcus Heldmann Jürgen Voges Jürgen Voges Hermann Hinrichs Josep Marco-Pallares Jens-Max Hopf Jens-Max Hopf Ulf Müller Imke Galazky Volker Sturm Bernhard Bogerts Thomas F Münte |
spellingShingle |
Hans-Jochen Heinze Hans-Jochen Heinze Marcus Heldmann Marcus Heldmann Jürgen Voges Jürgen Voges Hermann Hinrichs Josep Marco-Pallares Jens-Max Hopf Jens-Max Hopf Ulf Müller Imke Galazky Volker Sturm Bernhard Bogerts Thomas F Münte Counteracting incentive sensitization in severe alcohol dependence using deep brain stimulation of the nucleus accumbens: clinical and basic science aspects Frontiers in Human Neuroscience Nucleus Accumbens Addiction Local Field Potentials deep brain stimulation (DBS) Action Monitoring reward processing |
author_facet |
Hans-Jochen Heinze Hans-Jochen Heinze Marcus Heldmann Marcus Heldmann Jürgen Voges Jürgen Voges Hermann Hinrichs Josep Marco-Pallares Jens-Max Hopf Jens-Max Hopf Ulf Müller Imke Galazky Volker Sturm Bernhard Bogerts Thomas F Münte |
author_sort |
Hans-Jochen Heinze |
title |
Counteracting incentive sensitization in severe alcohol dependence using deep brain stimulation of the nucleus accumbens: clinical and basic science aspects |
title_short |
Counteracting incentive sensitization in severe alcohol dependence using deep brain stimulation of the nucleus accumbens: clinical and basic science aspects |
title_full |
Counteracting incentive sensitization in severe alcohol dependence using deep brain stimulation of the nucleus accumbens: clinical and basic science aspects |
title_fullStr |
Counteracting incentive sensitization in severe alcohol dependence using deep brain stimulation of the nucleus accumbens: clinical and basic science aspects |
title_full_unstemmed |
Counteracting incentive sensitization in severe alcohol dependence using deep brain stimulation of the nucleus accumbens: clinical and basic science aspects |
title_sort |
counteracting incentive sensitization in severe alcohol dependence using deep brain stimulation of the nucleus accumbens: clinical and basic science aspects |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Human Neuroscience |
issn |
1662-5161 |
publishDate |
2009-09-01 |
description |
The ventral striatum / nucleus accumbens has been implicated in the craving for drugs and alcohol which is a major reason for relapse of addicted people. Craving might be induced by drug-related cues. This suggests that disruption of craving-related neural activity in the nucleus accumbens may significantly reduce craving in alcohol-dependent patients. Here we report on preliminary clinical and neurophysiological evidence in three male patients who were treated with high frequency deep brain stimulation of the nucleus accumbens bilaterally. All three had been alcohol dependent for many years, unable to abstain from drinking, and had experienced repeated relapses prior to the stimulation. After the operation, craving was greatly reduced and all three patients were able to abstain from drinking for extended periods of time. Immediately after the operation but prior to connection of the stimulation electrodes to the stimulator, local field potentials were obtained from the externalized cables in two patients while they performed cognitive tasks addressing action monitoring and incentive salience of drug related cues. LFPs in the action monitoring task provided further evidence for a role of the nucleus accumbens in goal-directed behaviors. Importantly, alcohol related cue stimuli in the incentive salience task modulated LFPs even though these cues were presented outside of the attentional focus. This implies that cue-related craving involves the nucleus accumbens and is highly automatic. |
topic |
Nucleus Accumbens Addiction Local Field Potentials deep brain stimulation (DBS) Action Monitoring reward processing |
url |
http://journal.frontiersin.org/Journal/10.3389/neuro.09.022.2009/full |
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