Correlation between discharged worms and fecal egg counts in human clonorchiasis.
BACKGROUND: Stool examination by counting eggs per gram of feces (EPGs) is the best method to estimate worm burden of Clonorchis sinensis in infected humans. The present study investigated a correlation between EPGs and worm burden in human clonorchiasis. METHODS AND FINDINGS: A total of 60 resident...
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doaj-9a11b0bee74f49088fefa5925a89edf12020-11-24T23:33:53ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27352011-10-01510e133910.1371/journal.pntd.0001339Correlation between discharged worms and fecal egg counts in human clonorchiasis.Jae-Hwan KimMin-Ho ChoiYoung Mee BaeJin-Kyoung OhMin Kyung LimSung-Tae HongBACKGROUND: Stool examination by counting eggs per gram of feces (EPGs) is the best method to estimate worm burden of Clonorchis sinensis in infected humans. The present study investigated a correlation between EPGs and worm burden in human clonorchiasis. METHODS AND FINDINGS: A total of 60 residents, 50 egg-positive and 10 egg-negative, in Sancheong-gun, Korea, participated in this worm collection trial in 2006-2009. They were diagnosed by egg positivity in feces using the Kato-Katz method. After administration of praziquantel, they were purged with cathartics on the next day, and then discharged adult worms were collected from their feces. Their EPGs ranged from 0 to 65,544. Adult worms of C. sinensis were collected from 17 egg-positive cases, and the number of worms ranged from 1 to 114 in each individual. A positive correlation between EPGs and numbers of worms was demonstrated (r = 0.681, P<0.001). Worm recovery rates were 9.7% in cases of EPGs 1-1,000 and 73.7% in those of EPGs over 1,000. No worms were detected from egg-negative subjects. Maximum egg count per worm per day was roughly estimated 3,770 in a subject with EPGs 2,664 and 106 collected worms. CONCLUSIONS: The numbers of the worms are significantly correlated with the egg counts in human clonorchiasis. It is estimated that at least 110 worms are infected in a human body with EPGs around 3,000, and egg productivity of a worm per day is around 4,000.http://europepmc.org/articles/PMC3186755?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jae-Hwan Kim Min-Ho Choi Young Mee Bae Jin-Kyoung Oh Min Kyung Lim Sung-Tae Hong |
spellingShingle |
Jae-Hwan Kim Min-Ho Choi Young Mee Bae Jin-Kyoung Oh Min Kyung Lim Sung-Tae Hong Correlation between discharged worms and fecal egg counts in human clonorchiasis. PLoS Neglected Tropical Diseases |
author_facet |
Jae-Hwan Kim Min-Ho Choi Young Mee Bae Jin-Kyoung Oh Min Kyung Lim Sung-Tae Hong |
author_sort |
Jae-Hwan Kim |
title |
Correlation between discharged worms and fecal egg counts in human clonorchiasis. |
title_short |
Correlation between discharged worms and fecal egg counts in human clonorchiasis. |
title_full |
Correlation between discharged worms and fecal egg counts in human clonorchiasis. |
title_fullStr |
Correlation between discharged worms and fecal egg counts in human clonorchiasis. |
title_full_unstemmed |
Correlation between discharged worms and fecal egg counts in human clonorchiasis. |
title_sort |
correlation between discharged worms and fecal egg counts in human clonorchiasis. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Neglected Tropical Diseases |
issn |
1935-2735 |
publishDate |
2011-10-01 |
description |
BACKGROUND: Stool examination by counting eggs per gram of feces (EPGs) is the best method to estimate worm burden of Clonorchis sinensis in infected humans. The present study investigated a correlation between EPGs and worm burden in human clonorchiasis. METHODS AND FINDINGS: A total of 60 residents, 50 egg-positive and 10 egg-negative, in Sancheong-gun, Korea, participated in this worm collection trial in 2006-2009. They were diagnosed by egg positivity in feces using the Kato-Katz method. After administration of praziquantel, they were purged with cathartics on the next day, and then discharged adult worms were collected from their feces. Their EPGs ranged from 0 to 65,544. Adult worms of C. sinensis were collected from 17 egg-positive cases, and the number of worms ranged from 1 to 114 in each individual. A positive correlation between EPGs and numbers of worms was demonstrated (r = 0.681, P<0.001). Worm recovery rates were 9.7% in cases of EPGs 1-1,000 and 73.7% in those of EPGs over 1,000. No worms were detected from egg-negative subjects. Maximum egg count per worm per day was roughly estimated 3,770 in a subject with EPGs 2,664 and 106 collected worms. CONCLUSIONS: The numbers of the worms are significantly correlated with the egg counts in human clonorchiasis. It is estimated that at least 110 worms are infected in a human body with EPGs around 3,000, and egg productivity of a worm per day is around 4,000. |
url |
http://europepmc.org/articles/PMC3186755?pdf=render |
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