| Summary: | Xanthelasma palpebrarum is a xanthomatous skin lesion sometimes associated with dyslipidemias. Little is known about the clinical significance of normolipemic xanthelasma lesions. We present a patient with localized Castleman's disease of plasma cell type, accompanied by prominent bilateral xanthelasma palpebrarum , intense systemic inflammatory reaction, polyclonal hypergammaglobulinemia and reactive amyloidosis (AA type). Curative resection of the mass resulted in regression of the clinical and biochemical abnormalities and substantial improvement of the xanthelasma lesions. In this patient the skin lesion could be connected pathogenetically with the underlying disease and may represent an early marker of it. Furthermore, the regression of this lesion suggests that dissolution of lipid accumulation in atheromatous lesions may be possible.
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