Mucosal responses to infection with Trichinella spiralis in mice
Infections with T. spiralis in mice elicit strong inflammatory responses. The nature and control of these responses, and their relationship to the process of worm expulsion, have been debated for many years. Many components of inflammation are, like worm expulsion, T cell-dependent, but some are not...
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EDP Sciences
2001-06-01
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Online Access: | http://dx.doi.org/10.1051/parasite/200108s2110 |
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doaj-9a1aa5869e794c1d91d2d39fabe10d6e2021-02-02T03:49:38ZengEDP SciencesParasite1252-607X1776-10422001-06-018S110S11310.1051/parasite/200108s2110parasite200108s2p110Mucosal responses to infection with Trichinella spiralis in miceKamal M.Wakelin D.Mahida Y.Infections with T. spiralis in mice elicit strong inflammatory responses. The nature and control of these responses, and their relationship to the process of worm expulsion, have been debated for many years. Many components of inflammation are, like worm expulsion, T cell-dependent, but some are not. The paper describes novel observations on Paneth cell responses to infection in immunologically normal mice and in a variety of T cell-deficient mice. Responses occurred normally in nu/nu and scid/scid mice but not in β/δ knock out mice incapable of generating cells with functional TCR. However all of these mice failed to expel worms in the pattern seen in immunologically normal controls. These data are incorporated into a discussion of the causal relevance of intestinal inflammatory changes to the process of worm expulsion.http://dx.doi.org/10.1051/parasite/200108s2110Trichinella spiralintestineworm expulsiomucosaepitheliuminflammationmast cellsgoblet cellsPaneth cellsT cellscytokines |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kamal M. Wakelin D. Mahida Y. |
spellingShingle |
Kamal M. Wakelin D. Mahida Y. Mucosal responses to infection with Trichinella spiralis in mice Parasite Trichinella spiral intestine worm expulsio mucosa epithelium inflammation mast cells goblet cells Paneth cells T cells cytokines |
author_facet |
Kamal M. Wakelin D. Mahida Y. |
author_sort |
Kamal M. |
title |
Mucosal responses to infection with Trichinella spiralis in mice |
title_short |
Mucosal responses to infection with Trichinella spiralis in mice |
title_full |
Mucosal responses to infection with Trichinella spiralis in mice |
title_fullStr |
Mucosal responses to infection with Trichinella spiralis in mice |
title_full_unstemmed |
Mucosal responses to infection with Trichinella spiralis in mice |
title_sort |
mucosal responses to infection with trichinella spiralis in mice |
publisher |
EDP Sciences |
series |
Parasite |
issn |
1252-607X 1776-1042 |
publishDate |
2001-06-01 |
description |
Infections with T. spiralis in mice elicit strong inflammatory responses. The nature and control of these responses, and their relationship to the process of worm expulsion, have been debated for many years. Many components of inflammation are, like worm expulsion, T cell-dependent, but some are not. The paper describes novel observations on Paneth cell responses to infection in immunologically normal mice and in a variety of T cell-deficient mice. Responses occurred normally in nu/nu and scid/scid mice but not in β/δ knock out mice incapable of generating cells with functional TCR. However all of these mice failed to expel worms in the pattern seen in immunologically normal controls. These data are incorporated into a discussion of the causal relevance of intestinal inflammatory changes to the process of worm expulsion. |
topic |
Trichinella spiral intestine worm expulsio mucosa epithelium inflammation mast cells goblet cells Paneth cells T cells cytokines |
url |
http://dx.doi.org/10.1051/parasite/200108s2110 |
work_keys_str_mv |
AT kamalm mucosalresponsestoinfectionwithtrichinellaspiralisinmice AT wakelind mucosalresponsestoinfectionwithtrichinellaspiralisinmice AT mahiday mucosalresponsestoinfectionwithtrichinellaspiralisinmice |
_version_ |
1724307030812917760 |