Computational Strategies for a System-Level Understanding of Metabolism

Computational Strategies for a System-Level Understanding of Metabolism

Cell metabolism is the biochemical machinery that provides energy and building blocks to sustain life. Understanding its fine regulation is of pivotal relevance in several fields, from metabolic engineering applications to the treatment of metabolic disorders and cancer. Sophisticated computational...

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Bibliographic Details
Main Authors: Paolo Cazzaniga, Chiara Damiani, Daniela Besozzi, Riccardo Colombo, Marco S. Nobile, Daniela Gaglio, Dario Pescini, Sara Molinari, Giancarlo Mauri, Lilia Alberghina, Marco Vanoni
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:Metabolites
Subjects:
metabolism
metabolome
modeling
systems biology
genome-wide model
constraint-based model
core model
mechanistic model
ensemble modeling
parameter estimation
reverse engineering
flux balance analysis
network analysis
sensitivity analysis
control theory
Online Access:http://www.mdpi.com/2218-1989/4/4/1034

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