Single-subject classification of presymptomatic frontotemporal dementia mutation carriers using multimodal MRI
Background: Classification models based on magnetic resonance imaging (MRI) may aid early diagnosis of frontotemporal dementia (FTD) but have only been applied in established FTD cases. Detection of FTD patients in earlier disease stages, such as presymptomatic mutation carriers, may further advance...
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Elsevier
2018-01-01
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Series: | NeuroImage: Clinical |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158218302262 |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rogier A. Feis Mark J.R.J. Bouts Jessica L. Panman Lize C. Jiskoot Elise G.P. Dopper Tijn M. Schouten Frank de Vos Jeroen van der Grond John C. van Swieten Serge A.R.B. Rombouts |
spellingShingle |
Rogier A. Feis Mark J.R.J. Bouts Jessica L. Panman Lize C. Jiskoot Elise G.P. Dopper Tijn M. Schouten Frank de Vos Jeroen van der Grond John C. van Swieten Serge A.R.B. Rombouts Single-subject classification of presymptomatic frontotemporal dementia mutation carriers using multimodal MRI NeuroImage: Clinical |
author_facet |
Rogier A. Feis Mark J.R.J. Bouts Jessica L. Panman Lize C. Jiskoot Elise G.P. Dopper Tijn M. Schouten Frank de Vos Jeroen van der Grond John C. van Swieten Serge A.R.B. Rombouts |
author_sort |
Rogier A. Feis |
title |
Single-subject classification of presymptomatic frontotemporal dementia mutation carriers using multimodal MRI |
title_short |
Single-subject classification of presymptomatic frontotemporal dementia mutation carriers using multimodal MRI |
title_full |
Single-subject classification of presymptomatic frontotemporal dementia mutation carriers using multimodal MRI |
title_fullStr |
Single-subject classification of presymptomatic frontotemporal dementia mutation carriers using multimodal MRI |
title_full_unstemmed |
Single-subject classification of presymptomatic frontotemporal dementia mutation carriers using multimodal MRI |
title_sort |
single-subject classification of presymptomatic frontotemporal dementia mutation carriers using multimodal mri |
publisher |
Elsevier |
series |
NeuroImage: Clinical |
issn |
2213-1582 |
publishDate |
2018-01-01 |
description |
Background: Classification models based on magnetic resonance imaging (MRI) may aid early diagnosis of frontotemporal dementia (FTD) but have only been applied in established FTD cases. Detection of FTD patients in earlier disease stages, such as presymptomatic mutation carriers, may further advance early diagnosis and treatment. In this study, we aim to distinguish presymptomatic FTD mutation carriers from controls on an individual level using multimodal MRI-based classification. Methods: Anatomical MRI, diffusion tensor imaging (DTI) and resting-state functional MRI data were collected in 55 presymptomatic FTD mutation carriers (8 microtubule-associated protein Tau, 35 progranulin, and 12 chromosome 9 open reading frame 72) and 48 familial controls. We calculated grey and white matter density features from anatomical MRI scans, diffusivity features from DTI, and functional connectivity features from resting-state functional MRI. These features were applied in a recently introduced multimodal behavioural variant FTD (bvFTD) classification model, and were subsequently used to train and test unimodal and multimodal carrier-control models. Classification performance was quantified using area under the receiver operator characteristic curves (AUC). Results: The bvFTD model was not able to separate presymptomatic carriers from controls beyond chance level (AUC = 0.570, p = 0.11). In contrast, one unimodal and several multimodal carrier-control models performed significantly better than chance level. The unimodal model included the radial diffusivity feature and had an AUC of 0.646 (p = 0.021). The best multimodal model combined radial diffusivity and white matter density features (AUC = 0.680, p = 0.005). Conclusions: FTD mutation carriers can be separated from controls with a modest AUC even before symptom-onset, using a newly created carrier-control classification model, while this was not possible using a recent bvFTD classification model. A multimodal MRI-based classification score may therefore be a useful biomarker to aid earlier FTD diagnosis. The exclusive selection of white matter features in the best performing model suggests that the earliest FTD-related pathological processes occur in white matter. Keywords: Frontotemporal dementia, MAPT protein, human, GRN protein, human, C9orf72, human, Diffusion Tensor Imaging, Resting-state functional MRI, Multimodal MRI, classification, machine learning |
url |
http://www.sciencedirect.com/science/article/pii/S2213158218302262 |
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doaj-9a29e15776314ded9072abf1b11f3a872020-11-25T01:21:15ZengElsevierNeuroImage: Clinical2213-15822018-01-0120188196Single-subject classification of presymptomatic frontotemporal dementia mutation carriers using multimodal MRIRogier A. Feis0Mark J.R.J. Bouts1Jessica L. Panman2Lize C. Jiskoot3Elise G.P. Dopper4Tijn M. Schouten5Frank de Vos6Jeroen van der Grond7John C. van Swieten8Serge A.R.B. Rombouts9Department of Radiology, Leiden University Medical Centre, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden University, Leiden, the Netherlands; Corresponding author at: Department of Radiology, Leiden University Medical Centre, Leiden, the Netherlands.Department of Radiology, Leiden University Medical Centre, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden University, Leiden, the Netherlands; Institute of Psychology, Leiden University, Leiden, the NetherlandsDepartment of Radiology, Leiden University Medical Centre, Leiden, the Netherlands; Department of Neurology, Erasmus Medical Centre, Rotterdam, the NetherlandsDepartment of Radiology, Leiden University Medical Centre, Leiden, the Netherlands; Department of Neurology, Erasmus Medical Centre, Rotterdam, the NetherlandsDepartment of Radiology, Leiden University Medical Centre, Leiden, the Netherlands; Department of Neurology, Erasmus Medical Centre, Rotterdam, the Netherlands; Alzheimer Centre & Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, the NetherlandsDepartment of Radiology, Leiden University Medical Centre, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden University, Leiden, the Netherlands; Institute of Psychology, Leiden University, Leiden, the NetherlandsDepartment of Radiology, Leiden University Medical Centre, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden University, Leiden, the Netherlands; Institute of Psychology, Leiden University, Leiden, the NetherlandsDepartment of Radiology, Leiden University Medical Centre, Leiden, the NetherlandsDepartment of Neurology, Erasmus Medical Centre, Rotterdam, the Netherlands; Department of Clinical Genetics, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, the NetherlandsDepartment of Radiology, Leiden University Medical Centre, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden University, Leiden, the Netherlands; Institute of Psychology, Leiden University, Leiden, the NetherlandsBackground: Classification models based on magnetic resonance imaging (MRI) may aid early diagnosis of frontotemporal dementia (FTD) but have only been applied in established FTD cases. Detection of FTD patients in earlier disease stages, such as presymptomatic mutation carriers, may further advance early diagnosis and treatment. In this study, we aim to distinguish presymptomatic FTD mutation carriers from controls on an individual level using multimodal MRI-based classification. Methods: Anatomical MRI, diffusion tensor imaging (DTI) and resting-state functional MRI data were collected in 55 presymptomatic FTD mutation carriers (8 microtubule-associated protein Tau, 35 progranulin, and 12 chromosome 9 open reading frame 72) and 48 familial controls. We calculated grey and white matter density features from anatomical MRI scans, diffusivity features from DTI, and functional connectivity features from resting-state functional MRI. These features were applied in a recently introduced multimodal behavioural variant FTD (bvFTD) classification model, and were subsequently used to train and test unimodal and multimodal carrier-control models. Classification performance was quantified using area under the receiver operator characteristic curves (AUC). Results: The bvFTD model was not able to separate presymptomatic carriers from controls beyond chance level (AUC = 0.570, p = 0.11). In contrast, one unimodal and several multimodal carrier-control models performed significantly better than chance level. The unimodal model included the radial diffusivity feature and had an AUC of 0.646 (p = 0.021). The best multimodal model combined radial diffusivity and white matter density features (AUC = 0.680, p = 0.005). Conclusions: FTD mutation carriers can be separated from controls with a modest AUC even before symptom-onset, using a newly created carrier-control classification model, while this was not possible using a recent bvFTD classification model. A multimodal MRI-based classification score may therefore be a useful biomarker to aid earlier FTD diagnosis. The exclusive selection of white matter features in the best performing model suggests that the earliest FTD-related pathological processes occur in white matter. Keywords: Frontotemporal dementia, MAPT protein, human, GRN protein, human, C9orf72, human, Diffusion Tensor Imaging, Resting-state functional MRI, Multimodal MRI, classification, machine learninghttp://www.sciencedirect.com/science/article/pii/S2213158218302262 |