Comparing ganglion cell-inner plexiform layer thickness with focal and global responses on multifocal electroretinogram in glaucoma
BACKGROUND: The aim of this study was to evaluate responses on multifocal electroretinogram (mfERG) with ganglion cell-inner plexiform layer (GCIPL) thickness on cirrus spectral-domain optical coherence tomography (SD-OCT) in glaucoma. METHODS: All diagnosed glaucoma patients attending glaucoma serv...
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Wolters Kluwer Medknow Publications
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doaj-9a2c5a66d1b241739b4e1fba9b6195de2020-11-25T00:47:22ZengWolters Kluwer Medknow PublicationsOman Journal of Ophthalmology0974-620X2017-01-0110320521210.4103/ojo.OJO_15_2015Comparing ganglion cell-inner plexiform layer thickness with focal and global responses on multifocal electroretinogram in glaucomaAparna RaoRohit V ChandrashekharDebananda PadhySujoy MukherjeeGopinath DasSarada SarangiBACKGROUND: The aim of this study was to evaluate responses on multifocal electroretinogram (mfERG) with ganglion cell-inner plexiform layer (GCIPL) thickness on cirrus spectral-domain optical coherence tomography (SD-OCT) in glaucoma. METHODS: All diagnosed glaucoma patients attending glaucoma services at our institute from November 2012 to April 2013 were screened for this observational hospital-based study. Controls included patients attending our outpatient services for general eye checkup. Structural parameters on SD-OCT including GCIPL and retinal nerve fiber layer (RNFL) thickness were compared with functional parameters on mfERG in early (mean deviation −6 dB), moderate (−6 to − 12 dB), and controls. RESULTS: A total of 54 cases and 33 controls fulfilling inclusion criteria were recruited for the study. The average and minimum GCIPL thickness did not vary significantly between early and control eyes while moderate glaucoma eyes had marginally lower GCIPL thickness than early glaucoma eyes. The GCIPL minimum thickness on univariate regression was found to be influenced by N2 amplitudes (β = −0.5, P = 0.012) and global N2P1amplitudes (β =0.6, P = 0.01) in moderate glaucoma. In early glaucoma, these were influenced only by RNFL parameters with no association with functional mfERG responses. Multivariate logistic regression identified global N2P1 amplitude to be significantly influencing GCIPL average and minimum thickness (P = 0.01 and 0.02, R2 = 47.8% and 52.3%, respectively) in moderate glaucoma. Maximum area under the curve was found for GCIPL minimum (95% confidence interval [CI] 0.53–0.81) and N2P1 amplitude (95% CI 0.55–0.80). CONCLUSIONS: The second order responses N2P1 and N2 amplitude on mfERG predict function that correlated with structural GCIPL thickness in moderate glaucoma. Early glaucoma may be best predicted by RNFL thickness rather than on mfERG responses.http://www.ojoonline.org/article.asp?issn=0974-620X;year=2017;volume=10;issue=3;spage=205;epage=212;aulast=RaoElectrophysiologyglaucomamultifocal electroretinogramoptical coherence tomographystructure-function |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aparna Rao Rohit V Chandrashekhar Debananda Padhy Sujoy Mukherjee Gopinath Das Sarada Sarangi |
spellingShingle |
Aparna Rao Rohit V Chandrashekhar Debananda Padhy Sujoy Mukherjee Gopinath Das Sarada Sarangi Comparing ganglion cell-inner plexiform layer thickness with focal and global responses on multifocal electroretinogram in glaucoma Oman Journal of Ophthalmology Electrophysiology glaucoma multifocal electroretinogram optical coherence tomography structure-function |
author_facet |
Aparna Rao Rohit V Chandrashekhar Debananda Padhy Sujoy Mukherjee Gopinath Das Sarada Sarangi |
author_sort |
Aparna Rao |
title |
Comparing ganglion cell-inner plexiform layer thickness with focal and global responses on multifocal electroretinogram in glaucoma |
title_short |
Comparing ganglion cell-inner plexiform layer thickness with focal and global responses on multifocal electroretinogram in glaucoma |
title_full |
Comparing ganglion cell-inner plexiform layer thickness with focal and global responses on multifocal electroretinogram in glaucoma |
title_fullStr |
Comparing ganglion cell-inner plexiform layer thickness with focal and global responses on multifocal electroretinogram in glaucoma |
title_full_unstemmed |
Comparing ganglion cell-inner plexiform layer thickness with focal and global responses on multifocal electroretinogram in glaucoma |
title_sort |
comparing ganglion cell-inner plexiform layer thickness with focal and global responses on multifocal electroretinogram in glaucoma |
publisher |
Wolters Kluwer Medknow Publications |
series |
Oman Journal of Ophthalmology |
issn |
0974-620X |
publishDate |
2017-01-01 |
description |
BACKGROUND: The aim of this study was to evaluate responses on multifocal electroretinogram (mfERG) with ganglion cell-inner plexiform layer (GCIPL) thickness on cirrus spectral-domain optical coherence tomography (SD-OCT) in glaucoma.
METHODS: All diagnosed glaucoma patients attending glaucoma services at our institute from November 2012 to April 2013 were screened for this observational hospital-based study. Controls included patients attending our outpatient services for general eye checkup. Structural parameters on SD-OCT including GCIPL and retinal nerve fiber layer (RNFL) thickness were compared with functional parameters on mfERG in early (mean deviation −6 dB), moderate (−6 to − 12 dB), and controls.
RESULTS: A total of 54 cases and 33 controls fulfilling inclusion criteria were recruited for the study. The average and minimum GCIPL thickness did not vary significantly between early and control eyes while moderate glaucoma eyes had marginally lower GCIPL thickness than early glaucoma eyes. The GCIPL minimum thickness on univariate regression was found to be influenced by N2 amplitudes (β = −0.5, P = 0.012) and global N2P1amplitudes (β =0.6, P = 0.01) in moderate glaucoma. In early glaucoma, these were influenced only by RNFL parameters with no association with functional mfERG responses. Multivariate logistic regression identified global N2P1 amplitude to be significantly influencing GCIPL average and minimum thickness (P = 0.01 and 0.02, R2 = 47.8% and 52.3%, respectively) in moderate glaucoma. Maximum area under the curve was found for GCIPL minimum (95% confidence interval [CI] 0.53–0.81) and N2P1 amplitude (95% CI 0.55–0.80).
CONCLUSIONS: The second order responses N2P1 and N2 amplitude on mfERG predict function that correlated with structural GCIPL thickness in moderate glaucoma. Early glaucoma may be best predicted by RNFL thickness rather than on mfERG responses. |
topic |
Electrophysiology glaucoma multifocal electroretinogram optical coherence tomography structure-function |
url |
http://www.ojoonline.org/article.asp?issn=0974-620X;year=2017;volume=10;issue=3;spage=205;epage=212;aulast=Rao |
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