Neurorestorative process, law, and mechanisms

• Main Authors: Huang H, Chen L
• Format: Article
• Language: English
• Published: Tsinghua University Press 2015-02-01
• Series: Journal of Neurorestoratology
• Online Access: http://www.dovepress.com/neurorestorative-process-law-and-mechanisms-peer-reviewed-article-JN

Hongyun Huang,1–3 Lin Chen3–5 1General Hospital of Armed Police Forces, 2Beijing Rehabilitation Hospital of Capital Medical University, 3Beijing Hongtianji Neuroscience Academy, 4Tsinghua University Yuquan Hospital, 5Medical Center, Tsinghua University, Beijing, People's Republic of ChinaAbstract: Neurorestoration, or restoration of neurological function, can be achieved by different strategies through a series of neurorestorative mechanisms, including neuroprotection, neuromodulation, neuroplasticity, immunomodulation, axonal regeneration and sprouting, remyelination or neurorepair, neuroregeneration or neurogenesis, and neuroreplacement. Unfortunately, these mechanisms have been studied and viewed in isolation. The aim of this review is to generalize all attacking insults and restoring mechanisms as a complete neurorestorative process, then analyze the changing process of dynamic interaction between neural insults and restorative mechanisms, and highlight neurorestorative law, ie, “smaller or larger self-restoration always occurs by nature while facing insults, active and appropriate medical intervention is able to better restore functions and/or structures”. This review also briefly describes several important neurorestorative mechanisms.Keywords: neurorestoration, strategies, mechanisms, neurorestorative process, neurorestorative law, neurorestoratology