The role of the blood group-related glycosyltransferases FUT2 and B4GALNT2 in susceptibility to infectious disease
The glycosylation profile of the gastrointestinal tract is an important factor mediating host-microbe interactions. Variation in these glycan structures is often mediated by blood group-related glycosyltransferases, and can lead to wide-ranging differences in susceptibility to both infectious- as we...
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2021-04-01
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doaj-9a5cb7f83316463a9a14c308bd2c340d2021-06-05T06:04:06ZengElsevierInternational Journal of Medical Microbiology1438-42212021-04-013113151487The role of the blood group-related glycosyltransferases FUT2 and B4GALNT2 in susceptibility to infectious diseaseAlibek Galeev0Abdulhadi Suwandi1Aleksa Cepic2Meghna Basu3John F. Baines4Guntram A. Grassl5Max Planck Institute for Evolutionary Biology, Plön, Germany and Institute for Experimental Medicine, Kiel University, Kiel, GermanyInstitute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School and German Center for Infection Research (DZIF), Hannover, GermanyMax Planck Institute for Evolutionary Biology, Plön, Germany and Institute for Experimental Medicine, Kiel University, Kiel, GermanyMax Planck Institute for Evolutionary Biology, Plön, Germany and Institute for Experimental Medicine, Kiel University, Kiel, GermanyMax Planck Institute for Evolutionary Biology, Plön, Germany and Institute for Experimental Medicine, Kiel University, Kiel, Germany; Corresponding authors.Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School and German Center for Infection Research (DZIF), Hannover, Germany; Corresponding authors.The glycosylation profile of the gastrointestinal tract is an important factor mediating host-microbe interactions. Variation in these glycan structures is often mediated by blood group-related glycosyltransferases, and can lead to wide-ranging differences in susceptibility to both infectious- as well as chronic disease. In this review, we focus on the interplay between host glycosylation, the intestinal microbiota and susceptibility to gastrointestinal pathogens based on studies of two exemplary blood group-related glycosyltransferases that are conserved between mice and humans, namely FUT2 and B4GALNT2. We highlight that differences in susceptibility can arise due to both changes in direct interactions, such as bacterial adhesion, as well as indirect effects mediated by the intestinal microbiota. Although a large body of experimental work exists for direct interactions between host and pathogen, determining the more complex and variable mechanisms underlying three-way interactions involving the intestinal microbiota will be the subject of much-needed future research.http://www.sciencedirect.com/science/article/pii/S1438422121000163GlycosyltransferasesHisto-blood group antigensPathogensAdhesionNutrientsMicrobiota |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alibek Galeev Abdulhadi Suwandi Aleksa Cepic Meghna Basu John F. Baines Guntram A. Grassl |
spellingShingle |
Alibek Galeev Abdulhadi Suwandi Aleksa Cepic Meghna Basu John F. Baines Guntram A. Grassl The role of the blood group-related glycosyltransferases FUT2 and B4GALNT2 in susceptibility to infectious disease International Journal of Medical Microbiology Glycosyltransferases Histo-blood group antigens Pathogens Adhesion Nutrients Microbiota |
author_facet |
Alibek Galeev Abdulhadi Suwandi Aleksa Cepic Meghna Basu John F. Baines Guntram A. Grassl |
author_sort |
Alibek Galeev |
title |
The role of the blood group-related glycosyltransferases FUT2 and B4GALNT2 in susceptibility to infectious disease |
title_short |
The role of the blood group-related glycosyltransferases FUT2 and B4GALNT2 in susceptibility to infectious disease |
title_full |
The role of the blood group-related glycosyltransferases FUT2 and B4GALNT2 in susceptibility to infectious disease |
title_fullStr |
The role of the blood group-related glycosyltransferases FUT2 and B4GALNT2 in susceptibility to infectious disease |
title_full_unstemmed |
The role of the blood group-related glycosyltransferases FUT2 and B4GALNT2 in susceptibility to infectious disease |
title_sort |
role of the blood group-related glycosyltransferases fut2 and b4galnt2 in susceptibility to infectious disease |
publisher |
Elsevier |
series |
International Journal of Medical Microbiology |
issn |
1438-4221 |
publishDate |
2021-04-01 |
description |
The glycosylation profile of the gastrointestinal tract is an important factor mediating host-microbe interactions. Variation in these glycan structures is often mediated by blood group-related glycosyltransferases, and can lead to wide-ranging differences in susceptibility to both infectious- as well as chronic disease. In this review, we focus on the interplay between host glycosylation, the intestinal microbiota and susceptibility to gastrointestinal pathogens based on studies of two exemplary blood group-related glycosyltransferases that are conserved between mice and humans, namely FUT2 and B4GALNT2. We highlight that differences in susceptibility can arise due to both changes in direct interactions, such as bacterial adhesion, as well as indirect effects mediated by the intestinal microbiota. Although a large body of experimental work exists for direct interactions between host and pathogen, determining the more complex and variable mechanisms underlying three-way interactions involving the intestinal microbiota will be the subject of much-needed future research. |
topic |
Glycosyltransferases Histo-blood group antigens Pathogens Adhesion Nutrients Microbiota |
url |
http://www.sciencedirect.com/science/article/pii/S1438422121000163 |
work_keys_str_mv |
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