Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy
Understanding factors that impact CAR T cell expansion in the clinic is crucial to improving its therapeutic success. Here the authors document heterogeneity in the clonal dynamics of CAR-T cells by tracking individual clones using the endogenous TCR and integration sites and provide further insight...
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Bibliographic Details
Main Authors: |
Alyssa Sheih,
Valentin Voillet,
Laïla-Aïcha Hanafi,
Hannah A. DeBerg,
Masanao Yajima,
Reed Hawkins,
Vivian Gersuk,
Stanley R. Riddell,
David G. Maloney,
Martin E. Wohlfahrt,
Dnyanada Pande,
Mark R. Enstrom,
Hans-Peter Kiem,
Jennifer E. Adair,
Raphaël Gottardo,
Peter S. Linsley,
Cameron J. Turtle |
Format: | Article
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Language: | English |
Published: |
Nature Publishing Group
2020-01-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-019-13880-1
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