Usefulness of pretransplant aortic arch calcification evaluation for kidney transplant outcome prediction in one year follow-up
Vascular calcification (VC) is linked to post-transplant cardiovascular events and hypercalcemia which may influence kidney graft function in the long term. We aimed to evaluate whether pretransplant aortic arch calcification (AoAC) can predict post-transplant cardiovascular or cerebrovascular event...
Main Authors: | , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Taylor & Francis Group
2018-10-01
|
Series: | Renal Failure |
Subjects: | |
Online Access: | http://dx.doi.org/10.1080/0886022X.2018.1455588 |
id |
doaj-9a5f7ecc22294130947c63aaee62fdb0 |
---|---|
record_format |
Article |
spelling |
doaj-9a5f7ecc22294130947c63aaee62fdb02020-11-25T02:36:01ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492018-10-0140120120810.1080/0886022X.2018.14555881455588Usefulness of pretransplant aortic arch calcification evaluation for kidney transplant outcome prediction in one year follow-upAgne Laucyte-Cibulskiene0Evelina Boreikaite1Gediminas Aucina2Migle Gudynaite3Ilona Rudminiene4Sigita Anisko5Loreta Vareikiene6Liutauras Gumbys7Dileta Valanciene8Ligita Ryliskyte9Kestutis Strupas10Laurynas Rimsevicius11Marius Miglinas12Clinic of Gastroneterology, Nephrourology and Abdominal Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius UniversityVilnius UniversityVilnius UniversityCentre of Nephrology, Vilnius University Hospital Santaros ClinicsCentre of Nephrology, Vilnius University Hospital Santaros ClinicsCentre of Nephrology, Vilnius University Hospital Santaros ClinicsCentre of Nephrology, Vilnius University Hospital Santaros ClinicsVilnius University Hospital Santaros ClinicsVilnius UniversityVilnius UniversityClinic of Gastroneterology, Nephrourology and Abdominal Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius UniversityClinic of Gastroneterology, Nephrourology and Abdominal Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius UniversityClinic of Gastroneterology, Nephrourology and Abdominal Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius UniversityVascular calcification (VC) is linked to post-transplant cardiovascular events and hypercalcemia which may influence kidney graft function in the long term. We aimed to evaluate whether pretransplant aortic arch calcification (AoAC) can predict post-transplant cardiovascular or cerebrovascular events (CVEs), and to assess its association with post-transplant plasma calcium levels and renal function in one-year follow-up. Our single-center observational prospective study enrolled 37 kidney transplant recipients (KTR) without previous history of vascular events. Two radiologists evaluated pretransplant AoAC on chest X-ray as suggested by Ogawa et al. in 2009. Cohen’s kappa coefficient was 0.71. The mismatching results were repeatedly reviewed and resulted in consensus. Carotid-femoral (cfPWV) and carotid-radial pulse wave velocity (crPWV) was measured using applanation tonometry before and one year after transplantation. Patient clinical, biochemical data, and cardiovascular/CVE rate were monitored within 1 year. We found out that eGFR1year correlated with eGFRdischarge and calcium based on hospital discharge data (β = 0.563, p = .004 and β = 51.360, p = .026, respectively). Multivariate linear regression revealed that donor age, donor gender, and recipient eGFRdischarge (R-squared 0.65, p = .002) better predict eGFR1year than AoAC combined with recipient eGFRdischarge (R-squared 0.35, p = .006). During 1-year follow-up, four (10.81%) patients experienced cardiovascular events, which were predicted by PWV ratio (HR 7.549, p = .045), but not related to AoAC score (HR 1.044, p = .158). In conclusion, KTR without previous vascular events have quite low cardiovascular/CVE rate within 1-year follow-up. VC evaluated as AoAC on pretransplant chest X-ray together with recipient eGFRdischarge could be related to kidney function in one-year follow-up.http://dx.doi.org/10.1080/0886022X.2018.1455588Kidney transplantationaortic arch calcificationaortic stiffnesscardiovascular eventskidney graft function |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Agne Laucyte-Cibulskiene Evelina Boreikaite Gediminas Aucina Migle Gudynaite Ilona Rudminiene Sigita Anisko Loreta Vareikiene Liutauras Gumbys Dileta Valanciene Ligita Ryliskyte Kestutis Strupas Laurynas Rimsevicius Marius Miglinas |
spellingShingle |
Agne Laucyte-Cibulskiene Evelina Boreikaite Gediminas Aucina Migle Gudynaite Ilona Rudminiene Sigita Anisko Loreta Vareikiene Liutauras Gumbys Dileta Valanciene Ligita Ryliskyte Kestutis Strupas Laurynas Rimsevicius Marius Miglinas Usefulness of pretransplant aortic arch calcification evaluation for kidney transplant outcome prediction in one year follow-up Renal Failure Kidney transplantation aortic arch calcification aortic stiffness cardiovascular events kidney graft function |
author_facet |
Agne Laucyte-Cibulskiene Evelina Boreikaite Gediminas Aucina Migle Gudynaite Ilona Rudminiene Sigita Anisko Loreta Vareikiene Liutauras Gumbys Dileta Valanciene Ligita Ryliskyte Kestutis Strupas Laurynas Rimsevicius Marius Miglinas |
author_sort |
Agne Laucyte-Cibulskiene |
title |
Usefulness of pretransplant aortic arch calcification evaluation for kidney transplant outcome prediction in one year follow-up |
title_short |
Usefulness of pretransplant aortic arch calcification evaluation for kidney transplant outcome prediction in one year follow-up |
title_full |
Usefulness of pretransplant aortic arch calcification evaluation for kidney transplant outcome prediction in one year follow-up |
title_fullStr |
Usefulness of pretransplant aortic arch calcification evaluation for kidney transplant outcome prediction in one year follow-up |
title_full_unstemmed |
Usefulness of pretransplant aortic arch calcification evaluation for kidney transplant outcome prediction in one year follow-up |
title_sort |
usefulness of pretransplant aortic arch calcification evaluation for kidney transplant outcome prediction in one year follow-up |
publisher |
Taylor & Francis Group |
series |
Renal Failure |
issn |
0886-022X 1525-6049 |
publishDate |
2018-10-01 |
description |
Vascular calcification (VC) is linked to post-transplant cardiovascular events and hypercalcemia which may influence kidney graft function in the long term. We aimed to evaluate whether pretransplant aortic arch calcification (AoAC) can predict post-transplant cardiovascular or cerebrovascular events (CVEs), and to assess its association with post-transplant plasma calcium levels and renal function in one-year follow-up. Our single-center observational prospective study enrolled 37 kidney transplant recipients (KTR) without previous history of vascular events. Two radiologists evaluated pretransplant AoAC on chest X-ray as suggested by Ogawa et al. in 2009. Cohen’s kappa coefficient was 0.71. The mismatching results were repeatedly reviewed and resulted in consensus. Carotid-femoral (cfPWV) and carotid-radial pulse wave velocity (crPWV) was measured using applanation tonometry before and one year after transplantation. Patient clinical, biochemical data, and cardiovascular/CVE rate were monitored within 1 year. We found out that eGFR1year correlated with eGFRdischarge and calcium based on hospital discharge data (β = 0.563, p = .004 and β = 51.360, p = .026, respectively). Multivariate linear regression revealed that donor age, donor gender, and recipient eGFRdischarge (R-squared 0.65, p = .002) better predict eGFR1year than AoAC combined with recipient eGFRdischarge (R-squared 0.35, p = .006). During 1-year follow-up, four (10.81%) patients experienced cardiovascular events, which were predicted by PWV ratio (HR 7.549, p = .045), but not related to AoAC score (HR 1.044, p = .158). In conclusion, KTR without previous vascular events have quite low cardiovascular/CVE rate within 1-year follow-up. VC evaluated as AoAC on pretransplant chest X-ray together with recipient eGFRdischarge could be related to kidney function in one-year follow-up. |
topic |
Kidney transplantation aortic arch calcification aortic stiffness cardiovascular events kidney graft function |
url |
http://dx.doi.org/10.1080/0886022X.2018.1455588 |
work_keys_str_mv |
AT agnelaucytecibulskiene usefulnessofpretransplantaorticarchcalcificationevaluationforkidneytransplantoutcomepredictioninoneyearfollowup AT evelinaboreikaite usefulnessofpretransplantaorticarchcalcificationevaluationforkidneytransplantoutcomepredictioninoneyearfollowup AT gediminasaucina usefulnessofpretransplantaorticarchcalcificationevaluationforkidneytransplantoutcomepredictioninoneyearfollowup AT miglegudynaite usefulnessofpretransplantaorticarchcalcificationevaluationforkidneytransplantoutcomepredictioninoneyearfollowup AT ilonarudminiene usefulnessofpretransplantaorticarchcalcificationevaluationforkidneytransplantoutcomepredictioninoneyearfollowup AT sigitaanisko usefulnessofpretransplantaorticarchcalcificationevaluationforkidneytransplantoutcomepredictioninoneyearfollowup AT loretavareikiene usefulnessofpretransplantaorticarchcalcificationevaluationforkidneytransplantoutcomepredictioninoneyearfollowup AT liutaurasgumbys usefulnessofpretransplantaorticarchcalcificationevaluationforkidneytransplantoutcomepredictioninoneyearfollowup AT diletavalanciene usefulnessofpretransplantaorticarchcalcificationevaluationforkidneytransplantoutcomepredictioninoneyearfollowup AT ligitaryliskyte usefulnessofpretransplantaorticarchcalcificationevaluationforkidneytransplantoutcomepredictioninoneyearfollowup AT kestutisstrupas usefulnessofpretransplantaorticarchcalcificationevaluationforkidneytransplantoutcomepredictioninoneyearfollowup AT laurynasrimsevicius usefulnessofpretransplantaorticarchcalcificationevaluationforkidneytransplantoutcomepredictioninoneyearfollowup AT mariusmiglinas usefulnessofpretransplantaorticarchcalcificationevaluationforkidneytransplantoutcomepredictioninoneyearfollowup |
_version_ |
1724801895206223872 |