Hemato-Biochemical Disruptions by Lambda-Cyhalothrin in Rats
The present study assessed in vivo endocrine disrupting effect of orally administered lambda-cyhalothrin (LCT) on metabolic hormones and correlated it with hematological instabilities. Adult female albino rats were divided in three equal groups; one kept as control and other two treated with 20 and...
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University of Agriculture, Faisalabad
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doaj-9a60cdaf7c9240229ad7557c4c2e28972020-11-25T02:30:43ZengUniversity of Agriculture, FaisalabadPakistan Veterinary Journal0253-83182074-77642014-01-013415457Hemato-Biochemical Disruptions by Lambda-Cyhalothrin in RatsAsghar Ali0Junaid Ali Khan1Tanweer Khaliq2Ijaz Javed3Faqir Muhammad4Bilal Aslam5Muhammad Zargham Khan6Department of Physiology and Pharmacology, University of Agriculture, Faisalabad, PakistanDepartment of Physiology and Pharmacology, University of Agriculture, Faisalabad, PakistanDepartment of Physiology and Pharmacology, University of Agriculture, Faisalabad, PakistanDepartment of Physiology and Pharmacology, University of Agriculture, Faisalabad, PakistanDepartment of Physiology and Pharmacology, University of Agriculture, Faisalabad, PakistanDepartment of Physiology and Pharmacology, University of Agriculture, Faisalabad, PakistanDepartment of Pathology, University of Agriculture, Faisalabad, PakistanThe present study assessed in vivo endocrine disrupting effect of orally administered lambda-cyhalothrin (LCT) on metabolic hormones and correlated it with hematological instabilities. Adult female albino rats were divided in three equal groups; one kept as control and other two treated with 20 and 40 mg/kg BW LCT, respectively by oral gavage for 14 days. At the end of trial, blood was collected for hormonal and hematological analysis. The results showed that LCT led to reduction in serum triiodothyronine (T3) and thyroxin (T4) level (P<0.001) without modifying serum thyroid stimulating hormone (TSH) level in a dose related manner. Lambda-cyhalothrin also caused a significant (P<0.05) reduction in hemoglobin (Hb) concentration, red blood cell (RBC) count, total leukocyte count (TLC), platelets count, pack cell volume (PCV) and lymphocyte count. No significant variation was observed in erythrocytic indices. In sum, orally administered LCT caused reduction in feed intake and body weight along with disruption of hemato-biochemical parameters.http://pvj.com.pk/pdf-files/34_1/54-57.pdfHematologyLambda-cyhalothrinMetabolic disruptionPesticidesToxicity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Asghar Ali Junaid Ali Khan Tanweer Khaliq Ijaz Javed Faqir Muhammad Bilal Aslam Muhammad Zargham Khan |
spellingShingle |
Asghar Ali Junaid Ali Khan Tanweer Khaliq Ijaz Javed Faqir Muhammad Bilal Aslam Muhammad Zargham Khan Hemato-Biochemical Disruptions by Lambda-Cyhalothrin in Rats Pakistan Veterinary Journal Hematology Lambda-cyhalothrin Metabolic disruption Pesticides Toxicity |
author_facet |
Asghar Ali Junaid Ali Khan Tanweer Khaliq Ijaz Javed Faqir Muhammad Bilal Aslam Muhammad Zargham Khan |
author_sort |
Asghar Ali |
title |
Hemato-Biochemical Disruptions by Lambda-Cyhalothrin in Rats |
title_short |
Hemato-Biochemical Disruptions by Lambda-Cyhalothrin in Rats |
title_full |
Hemato-Biochemical Disruptions by Lambda-Cyhalothrin in Rats |
title_fullStr |
Hemato-Biochemical Disruptions by Lambda-Cyhalothrin in Rats |
title_full_unstemmed |
Hemato-Biochemical Disruptions by Lambda-Cyhalothrin in Rats |
title_sort |
hemato-biochemical disruptions by lambda-cyhalothrin in rats |
publisher |
University of Agriculture, Faisalabad |
series |
Pakistan Veterinary Journal |
issn |
0253-8318 2074-7764 |
publishDate |
2014-01-01 |
description |
The present study assessed in vivo endocrine disrupting effect of orally administered lambda-cyhalothrin (LCT) on metabolic hormones and correlated it with hematological instabilities. Adult female albino rats were divided in three equal groups; one kept as control and other two treated with 20 and 40 mg/kg BW LCT, respectively by oral gavage for 14 days. At the end of trial, blood was collected for hormonal and hematological analysis. The results showed that LCT led to reduction in serum triiodothyronine (T3) and thyroxin (T4) level (P<0.001) without modifying serum thyroid stimulating hormone (TSH) level in a dose related manner. Lambda-cyhalothrin also caused a significant (P<0.05) reduction in hemoglobin (Hb) concentration, red blood cell (RBC) count, total leukocyte count (TLC), platelets count, pack cell volume (PCV) and lymphocyte count. No significant variation was observed in erythrocytic indices. In sum, orally administered LCT caused reduction in feed intake and body weight along with disruption of hemato-biochemical parameters. |
topic |
Hematology Lambda-cyhalothrin Metabolic disruption Pesticides Toxicity |
url |
http://pvj.com.pk/pdf-files/34_1/54-57.pdf |
work_keys_str_mv |
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