Effect of zhenwu decoction combined with neoadjuvant chemotherapy on malignant characteristics of cancer cells in ovarian cancer
Objective: To explore the effect of zhenwu decoction combined with neoadjuvant chemotherapy on malignant characteristics of cancer cells in ovarian cancer. Methods: A total of 80 patients with ovarian cancer who underwent surgical treatment in this hospital between March 2015 and January 2017 wer...
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doaj-9a684c0f7243404b81eec2ba0fba5f302020-11-24T21:48:26ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372018-11-0124116568Effect of zhenwu decoction combined with neoadjuvant chemotherapy on malignant characteristics of cancer cells in ovarian cancerPing Zhou0Ming-Xia Shen1Ablajan Amdulla2 Department of Gynecology, the Affiliated Cancer Hospital of Xinjiang Medical University, Urumchi, Xinjiang, 830011 2 Department of Gynecology, the Affiliated Cancer Hospital of Xinjiang Medical University, Urumchi, Xinjiang, 830011 2 Hospital of Xinjiang Traditional Uyghur Medicine, Urumchi, Xinjiang, 830000Objective: To explore the effect of zhenwu decoction combined with neoadjuvant chemotherapy on malignant characteristics of cancer cells in ovarian cancer. Methods: A total of 80 patients with ovarian cancer who underwent surgical treatment in this hospital between March 2015 and January 2017 were divided into the control group (n=42) who received preoperative neoadjuvant chemotherapy and the zhenwu decoction group (n=38) who received preoperative zhenwu decoction combined with neoadjuvant chemotherapy. Intraoperative ovarian cancer tissue was kept to detect the expression of proliferation genes, invasion genes and autophagy genes through fluorescence quantitative PCR method. Results: Proliferation genes AKT, LSD1, SIRT1 and NOB1 mRNA expression in ovarian lesion tissue of zhenwu decoction group were lower than those of control group; invasion gene DACT1 mRNA expression was higher than that of control group whereas MTA1 and GRP78 mRNA expression were lower than those of control group; autophagy gene Beclin1 mRNA expression was higher than that of control group whereas LC3-Ⅱ and Atg5 mRNA expression were lower than those of control group. Conclusion: Preoperative zhenwu decoction combined with neoadjuvant chemotherapy can effectively inhibit the proliferation and invasion activity of tumor cells and regulate their autophagy function in patients with ovarian cancer.http://www.hnykdxxb.com/PDF/201811/16.pdf Ovarian cancerZhenwu decoctionNeoadjuvant chemotherapyProliferation geneInvasion geneAutophagy gene |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ping Zhou Ming-Xia Shen Ablajan Amdulla |
spellingShingle |
Ping Zhou Ming-Xia Shen Ablajan Amdulla Effect of zhenwu decoction combined with neoadjuvant chemotherapy on malignant characteristics of cancer cells in ovarian cancer Journal of Hainan Medical University Ovarian cancer Zhenwu decoction Neoadjuvant chemotherapy Proliferation gene Invasion gene Autophagy gene |
author_facet |
Ping Zhou Ming-Xia Shen Ablajan Amdulla |
author_sort |
Ping Zhou |
title |
Effect of zhenwu decoction combined with neoadjuvant chemotherapy on malignant characteristics of cancer cells in ovarian cancer |
title_short |
Effect of zhenwu decoction combined with neoadjuvant chemotherapy on malignant characteristics of cancer cells in ovarian cancer |
title_full |
Effect of zhenwu decoction combined with neoadjuvant chemotherapy on malignant characteristics of cancer cells in ovarian cancer |
title_fullStr |
Effect of zhenwu decoction combined with neoadjuvant chemotherapy on malignant characteristics of cancer cells in ovarian cancer |
title_full_unstemmed |
Effect of zhenwu decoction combined with neoadjuvant chemotherapy on malignant characteristics of cancer cells in ovarian cancer |
title_sort |
effect of zhenwu decoction combined with neoadjuvant chemotherapy on malignant characteristics of cancer cells in ovarian cancer |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2018-11-01 |
description |
Objective: To explore the effect of zhenwu decoction combined with neoadjuvant
chemotherapy on malignant characteristics of cancer cells in ovarian cancer. Methods: A
total of 80 patients with ovarian cancer who underwent surgical treatment in this hospital
between March 2015 and January 2017 were divided into the control group (n=42) who
received preoperative neoadjuvant chemotherapy and the zhenwu decoction group (n=38)
who received preoperative zhenwu decoction combined with neoadjuvant chemotherapy.
Intraoperative ovarian cancer tissue was kept to detect the expression of proliferation genes,
invasion genes and autophagy genes through fluorescence quantitative PCR method. Results:
Proliferation genes AKT, LSD1, SIRT1 and NOB1 mRNA expression in ovarian lesion tissue
of zhenwu decoction group were lower than those of control group; invasion gene DACT1
mRNA expression was higher than that of control group whereas MTA1 and GRP78 mRNA
expression were lower than those of control group; autophagy gene Beclin1 mRNA expression
was higher than that of control group whereas LC3-Ⅱ and Atg5 mRNA expression were
lower than those of control group. Conclusion: Preoperative zhenwu decoction combined with
neoadjuvant chemotherapy can effectively inhibit the proliferation and invasion activity of
tumor cells and regulate their autophagy function in patients with ovarian cancer. |
topic |
Ovarian cancer Zhenwu decoction Neoadjuvant chemotherapy Proliferation gene Invasion gene Autophagy gene |
url |
http://www.hnykdxxb.com/PDF/201811/16.pdf |
work_keys_str_mv |
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