Norovirus infection causes acute self-resolving diarrhea in wild-type neonatal mice

Here the authors show that a murine norovirus causes self-resolving diarrhea in the absence of systemic disease in wild-type neonatal mice and show that lymphocytes affect disease in a dual manner. The data suggests that neonatal mice are a promising model for further studies.

Bibliographic Details
Main Authors:	Alexa N. Roth, Emily W. Helm, Carmen Mirabelli, Erin Kirsche, Jonathan C. Smith, Laura B. Eurell, Sourish Ghosh, Nihal Altan-Bonnet, Christiane E. Wobus, Stephanie M. Karst
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-16798-1

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spelling	doaj-9a6932ec89e94268872ca25929c2bda72021-06-13T11:19:25ZengNature Publishing GroupNature Communications2041-17232020-06-011111810.1038/s41467-020-16798-1Norovirus infection causes acute self-resolving diarrhea in wild-type neonatal miceAlexa N. Roth0Emily W. Helm1Carmen Mirabelli2Erin Kirsche3Jonathan C. Smith4Laura B. Eurell5Sourish Ghosh6Nihal Altan-Bonnet7Christiane E. Wobus8Stephanie M. Karst9Department of Molecular Genetics & Microbiology, College of Medicine, University of FloridaDepartment of Molecular Genetics & Microbiology, College of Medicine, University of FloridaDepartment of Microbiology and Immunology, University of MichiganDepartment of Molecular Genetics & Microbiology, College of Medicine, University of FloridaDepartment of Molecular Genetics & Microbiology, College of Medicine, University of FloridaOffice of Research, College of Medicine, University of FloridaLaboratory of Host-Pathogen Dynamics, National Heart Lung and Blood Institute, National Institutes of HealthLaboratory of Host-Pathogen Dynamics, National Heart Lung and Blood Institute, National Institutes of HealthDepartment of Microbiology and Immunology, University of MichiganDepartment of Molecular Genetics & Microbiology, College of Medicine, University of FloridaHere the authors show that a murine norovirus causes self-resolving diarrhea in the absence of systemic disease in wild-type neonatal mice and show that lymphocytes affect disease in a dual manner. The data suggests that neonatal mice are a promising model for further studies.https://doi.org/10.1038/s41467-020-16798-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Alexa N. Roth Emily W. Helm Carmen Mirabelli Erin Kirsche Jonathan C. Smith Laura B. Eurell Sourish Ghosh Nihal Altan-Bonnet Christiane E. Wobus Stephanie M. Karst
spellingShingle	Alexa N. Roth Emily W. Helm Carmen Mirabelli Erin Kirsche Jonathan C. Smith Laura B. Eurell Sourish Ghosh Nihal Altan-Bonnet Christiane E. Wobus Stephanie M. Karst Norovirus infection causes acute self-resolving diarrhea in wild-type neonatal mice Nature Communications
author_facet	Alexa N. Roth Emily W. Helm Carmen Mirabelli Erin Kirsche Jonathan C. Smith Laura B. Eurell Sourish Ghosh Nihal Altan-Bonnet Christiane E. Wobus Stephanie M. Karst
author_sort	Alexa N. Roth
title	Norovirus infection causes acute self-resolving diarrhea in wild-type neonatal mice
title_short	Norovirus infection causes acute self-resolving diarrhea in wild-type neonatal mice
title_full	Norovirus infection causes acute self-resolving diarrhea in wild-type neonatal mice
title_fullStr	Norovirus infection causes acute self-resolving diarrhea in wild-type neonatal mice
title_full_unstemmed	Norovirus infection causes acute self-resolving diarrhea in wild-type neonatal mice
title_sort	norovirus infection causes acute self-resolving diarrhea in wild-type neonatal mice
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-06-01
description	Here the authors show that a murine norovirus causes self-resolving diarrhea in the absence of systemic disease in wild-type neonatal mice and show that lymphocytes affect disease in a dual manner. The data suggests that neonatal mice are a promising model for further studies.
url	https://doi.org/10.1038/s41467-020-16798-1
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Norovirus infection causes acute self-resolving diarrhea in wild-type neonatal mice

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