EZH2 in Cancer Progression and Potential Application in Cancer Therapy: A Friend or Foe?

EZH2 in Cancer Progression and Potential Application in Cancer Therapy: A Friend or Foe?

Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic machinery. EZH2 functions as a double-facet molecule in regulation of gene expression via repression or activation mechanisms,...

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Bibliographic Details
Main Authors: Ke-Sin Yan, Chia-Yuan Lin, Tan-Wei Liao, Cheng-Ming Peng, Shou-Chun Lee, Yi-Jui Liu, Wing P. Chan, Ruey-Hwang Chou
Format: Article
Language:English
Published: MDPI AG 2017-05-01
Series:International Journal of Molecular Sciences
Subjects:
EZH2
cancer
epigenetic regulation
microRNAs
lncRNAs
EZH2 inhibitors
Online Access:http://www.mdpi.com/1422-0067/18/6/1172

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