Decreased Gray Matter Volume of Cuneus and Lingual Gyrus in Schizophrenia Patients with Tardive Dyskinesia is Associated with Abnormal Involuntary Movement
Abstract Tardive dyskinesia (TD) is a devastating motor disorder associated with the etiological process of schizophrenia or antipsychotic medication treatments. To examine whether cerebral morphological changes may manifest in TD, we used voxel-based morphometry to analyze high-resolution T1-weight...
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doaj-9a7822d2ac9e4183a003d6464cc9eff62020-12-08T05:15:14ZengNature Publishing GroupScientific Reports2045-23222018-08-01811710.1038/s41598-018-31186-yDecreased Gray Matter Volume of Cuneus and Lingual Gyrus in Schizophrenia Patients with Tardive Dyskinesia is Associated with Abnormal Involuntary MovementTing Yu0Yanli Li1Fengmei Fan2Hongbao Cao3Xingguang Luo4Shuping Tan5Fude Yang6Xiangyang Zhang7Yin Yao Shugart8L. Elliot Hong9Chiang-Shan R. Li10Yunlong Tan11Peking University HuiLongGuan Clinical Medical SchoolPeking University HuiLongGuan Clinical Medical SchoolPeking University HuiLongGuan Clinical Medical SchoolUniton Statistical Genomics, National Institute of Mental Health, NIHDepartment of Psychiatry, Yale University School of MedicinePeking University HuiLongGuan Clinical Medical SchoolPeking University HuiLongGuan Clinical Medical SchoolPeking University HuiLongGuan Clinical Medical SchoolUniton Statistical Genomics, National Institute of Mental Health, NIHMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of MedicineDepartment of Psychiatry, Yale University School of MedicinePeking University HuiLongGuan Clinical Medical SchoolAbstract Tardive dyskinesia (TD) is a devastating motor disorder associated with the etiological process of schizophrenia or antipsychotic medication treatments. To examine whether cerebral morphological changes may manifest in TD, we used voxel-based morphometry to analyze high-resolution T1-weighted brain structural magnetic resonance images from 32 schizophrenics with TD (TD group), 31 schizophrenics without TD (non-TD group), and 32 healthy controls (HC group). We also assessed psychopathological symptoms with the Positive and Negative Syndrome Scale (PANSS), and TD severity with the Abnormal Involuntary Movement Scale (AIMS). We compared gray matter volumes (GMVs) among groups, and tested for correlations between GMV changes and psychopathological symptoms or TD severity. The results showed significant differences in GMV in the frontal and temporal cortices, insula and cerebellum among the three groups. Brainstem and inferior frontal and precentral gyri GMVs were significantly larger, whereas cuneus and lingual gyrus GMVs were significantly smaller in the TD group as compared to non-TD group. Further, the cuneus and lingual gyrus GMVs were positively correlated with AIMS scores in the TD group. The current results suggest that TD may be associated with the alterations in GMV that are different from that of schizophrenics without TD. Further studies are needed to confirm and to examine the functional significance of these structural findings.https://doi.org/10.1038/s41598-018-31186-y |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ting Yu Yanli Li Fengmei Fan Hongbao Cao Xingguang Luo Shuping Tan Fude Yang Xiangyang Zhang Yin Yao Shugart L. Elliot Hong Chiang-Shan R. Li Yunlong Tan |
spellingShingle |
Ting Yu Yanli Li Fengmei Fan Hongbao Cao Xingguang Luo Shuping Tan Fude Yang Xiangyang Zhang Yin Yao Shugart L. Elliot Hong Chiang-Shan R. Li Yunlong Tan Decreased Gray Matter Volume of Cuneus and Lingual Gyrus in Schizophrenia Patients with Tardive Dyskinesia is Associated with Abnormal Involuntary Movement Scientific Reports |
author_facet |
Ting Yu Yanli Li Fengmei Fan Hongbao Cao Xingguang Luo Shuping Tan Fude Yang Xiangyang Zhang Yin Yao Shugart L. Elliot Hong Chiang-Shan R. Li Yunlong Tan |
author_sort |
Ting Yu |
title |
Decreased Gray Matter Volume of Cuneus and Lingual Gyrus in Schizophrenia Patients with Tardive Dyskinesia is Associated with Abnormal Involuntary Movement |
title_short |
Decreased Gray Matter Volume of Cuneus and Lingual Gyrus in Schizophrenia Patients with Tardive Dyskinesia is Associated with Abnormal Involuntary Movement |
title_full |
Decreased Gray Matter Volume of Cuneus and Lingual Gyrus in Schizophrenia Patients with Tardive Dyskinesia is Associated with Abnormal Involuntary Movement |
title_fullStr |
Decreased Gray Matter Volume of Cuneus and Lingual Gyrus in Schizophrenia Patients with Tardive Dyskinesia is Associated with Abnormal Involuntary Movement |
title_full_unstemmed |
Decreased Gray Matter Volume of Cuneus and Lingual Gyrus in Schizophrenia Patients with Tardive Dyskinesia is Associated with Abnormal Involuntary Movement |
title_sort |
decreased gray matter volume of cuneus and lingual gyrus in schizophrenia patients with tardive dyskinesia is associated with abnormal involuntary movement |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2018-08-01 |
description |
Abstract Tardive dyskinesia (TD) is a devastating motor disorder associated with the etiological process of schizophrenia or antipsychotic medication treatments. To examine whether cerebral morphological changes may manifest in TD, we used voxel-based morphometry to analyze high-resolution T1-weighted brain structural magnetic resonance images from 32 schizophrenics with TD (TD group), 31 schizophrenics without TD (non-TD group), and 32 healthy controls (HC group). We also assessed psychopathological symptoms with the Positive and Negative Syndrome Scale (PANSS), and TD severity with the Abnormal Involuntary Movement Scale (AIMS). We compared gray matter volumes (GMVs) among groups, and tested for correlations between GMV changes and psychopathological symptoms or TD severity. The results showed significant differences in GMV in the frontal and temporal cortices, insula and cerebellum among the three groups. Brainstem and inferior frontal and precentral gyri GMVs were significantly larger, whereas cuneus and lingual gyrus GMVs were significantly smaller in the TD group as compared to non-TD group. Further, the cuneus and lingual gyrus GMVs were positively correlated with AIMS scores in the TD group. The current results suggest that TD may be associated with the alterations in GMV that are different from that of schizophrenics without TD. Further studies are needed to confirm and to examine the functional significance of these structural findings. |
url |
https://doi.org/10.1038/s41598-018-31186-y |
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