Drug discovery opportunities at the endothelin B receptor-related orphan G protein-coupled receptors, GPR37 and GPR37L1
Orphan G protein-coupled receptors (GPCRs) represent a largely untapped resource for the treatment of a variety of diseases, despite sophisticated advances in drug discovery. Two promising orphan GPCRs are the endothelin B receptor-like proteins, GPR37 (ET(B)R-LP, Pael-R) and GPR37L1 (ET(B)R-LP-2)....
Main Author: | Nicola J Smith |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2015-11-01
|
Series: | Frontiers in Pharmacology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00275/full |
Similar Items
-
Spatiotemporal Control of GPR37 Signaling and Its Behavioral Effects by Optogenetics
by: Wu Zheng, et al.
Published: (2018-03-01) -
Roles of the Orphan Receptor Gpr176-mediated G-protein Signaling in the Central Circadian Clock
by: Kunisue, Sumihiro
Published: (2019) -
Orphan receptor GPR158 controls stress-induced depression
by: Laurie P Sutton, et al.
Published: (2018-02-01) -
Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control
by: James L. J. Coleman, et al.
Published: (2018-04-01) -
Computational Investigations on the Binding Mode of Ligands for the Cannabinoid-Activated G Protein-Coupled Receptor GPR18
by: Alexander Neumann, et al.
Published: (2020-04-01)