Integrated molecular characterization of chondrosarcoma reveals critical determinants of disease progression
Chondrosarcomas are heterogenous tumours of the bone cartilage and have highly variable prognoses. Here, the authors perform a multi-omics analysis, revealing molecular features that can stratify clinical outcomes.
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Nature Publishing Group
2019-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12525-7 |
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doaj-9a7f2546f61d40c9b55be3f258fbc8df2021-05-11T12:17:15ZengNature Publishing GroupNature Communications2041-17232019-10-0110111110.1038/s41467-019-12525-7Integrated molecular characterization of chondrosarcoma reveals critical determinants of disease progressionRémy Nicolle0Mira Ayadi1Anne Gomez-Brouchet2Lucile Armenoult3Guillaume Banneau4Nabila Elarouci5Matthias Tallegas6Anne-Valérie Decouvelaere7Sébastien Aubert8Françoise Rédini9Béatrice Marie10Corinne Labit-Bouvier11Nicolas Reina12Marie Karanian13Louis-Romée le Nail14Philippe Anract15François Gouin16Frédérique Larousserie17Aurélien de Reyniès18Gonzague de Pinieux19Programme Cartes d’Identité des Tumeurs (CIT), Ligue Nationale Contre le CancerProgramme Cartes d’Identité des Tumeurs (CIT), Ligue Nationale Contre le CancerDepartment of Pathology, CHU de Toulouse – Oncopole, Université de ToulouseProgramme Cartes d’Identité des Tumeurs (CIT), Ligue Nationale Contre le CancerProgramme Cartes d’Identité des Tumeurs (CIT), Ligue Nationale Contre le CancerProgramme Cartes d’Identité des Tumeurs (CIT), Ligue Nationale Contre le CancerPlateforme de Génétique Moléculaire des Cancers, CHRU de ToursDepartment of Biopathology, Centre Léon BérardDepartment of Pathology, CHU de Lille, Université de LilleUMR1238 INSERM Université de Nantes, Sarcomes osseux et remodelage des tissus calcifiés, Faculté de médecineDepartment of Pathology, CHU de NancyDepartment of Pathology, CHU de Marseille, Aix Marseille Université, INSERM, MMGDepartment of Orthopedic Surgery, Hôpital Pierre-Paul Riquet, CHU de ToulouseDepartment of Biopathology, Centre Léon BérardUMR1238 INSERM Université de Nantes, Sarcomes osseux et remodelage des tissus calcifiés, Faculté de médecineDepartment of Orthopedic Surgery, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, Sorbonne Paris CitéDepartment of Surgery, Centre Léon BérardService de Pathologie, Hôpital Cochin, AP-HP, Université Paris DescartesProgramme Cartes d’Identité des Tumeurs (CIT), Ligue Nationale Contre le CancerUMR1238 INSERM Université de Nantes, Sarcomes osseux et remodelage des tissus calcifiés, Faculté de médecineChondrosarcomas are heterogenous tumours of the bone cartilage and have highly variable prognoses. Here, the authors perform a multi-omics analysis, revealing molecular features that can stratify clinical outcomes.https://doi.org/10.1038/s41467-019-12525-7 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Rémy Nicolle Mira Ayadi Anne Gomez-Brouchet Lucile Armenoult Guillaume Banneau Nabila Elarouci Matthias Tallegas Anne-Valérie Decouvelaere Sébastien Aubert Françoise Rédini Béatrice Marie Corinne Labit-Bouvier Nicolas Reina Marie Karanian Louis-Romée le Nail Philippe Anract François Gouin Frédérique Larousserie Aurélien de Reyniès Gonzague de Pinieux |
| spellingShingle |
Rémy Nicolle Mira Ayadi Anne Gomez-Brouchet Lucile Armenoult Guillaume Banneau Nabila Elarouci Matthias Tallegas Anne-Valérie Decouvelaere Sébastien Aubert Françoise Rédini Béatrice Marie Corinne Labit-Bouvier Nicolas Reina Marie Karanian Louis-Romée le Nail Philippe Anract François Gouin Frédérique Larousserie Aurélien de Reyniès Gonzague de Pinieux Integrated molecular characterization of chondrosarcoma reveals critical determinants of disease progression Nature Communications |
| author_facet |
Rémy Nicolle Mira Ayadi Anne Gomez-Brouchet Lucile Armenoult Guillaume Banneau Nabila Elarouci Matthias Tallegas Anne-Valérie Decouvelaere Sébastien Aubert Françoise Rédini Béatrice Marie Corinne Labit-Bouvier Nicolas Reina Marie Karanian Louis-Romée le Nail Philippe Anract François Gouin Frédérique Larousserie Aurélien de Reyniès Gonzague de Pinieux |
| author_sort |
Rémy Nicolle |
| title |
Integrated molecular characterization of chondrosarcoma reveals critical determinants of disease progression |
| title_short |
Integrated molecular characterization of chondrosarcoma reveals critical determinants of disease progression |
| title_full |
Integrated molecular characterization of chondrosarcoma reveals critical determinants of disease progression |
| title_fullStr |
Integrated molecular characterization of chondrosarcoma reveals critical determinants of disease progression |
| title_full_unstemmed |
Integrated molecular characterization of chondrosarcoma reveals critical determinants of disease progression |
| title_sort |
integrated molecular characterization of chondrosarcoma reveals critical determinants of disease progression |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-10-01 |
| description |
Chondrosarcomas are heterogenous tumours of the bone cartilage and have highly variable prognoses. Here, the authors perform a multi-omics analysis, revealing molecular features that can stratify clinical outcomes. |
| url |
https://doi.org/10.1038/s41467-019-12525-7 |
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