Internalization of a polysialic acid-binding Escherichia coli bacteriophage into eukaryotic neuroblastoma cells

Internalization of a polysialic acid-binding Escherichia coli bacteriophage into eukaryotic neuroblastoma cells

Eukaryotic organisms are continuously exposed to bacteriophages, but these are not thought to enter non-phagocytic cells. Here, Lehti et al. show that a bacteriophage can bind to a specific receptor on the surface of human neuroblastoma cells in vitro, and be internalized via the endolysosomal route...

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Main Authors: Timo A. Lehti, Maria I. Pajunen, Maria S. Skog, Jukka Finne
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02057-3
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spelling doaj-9a861fc04cc948d58d4f704dd1c2cac92021-05-11T07:23:36ZengNature Publishing GroupNature Communications2041-17232017-12-018111210.1038/s41467-017-02057-3Internalization of a polysialic acid-binding Escherichia coli bacteriophage into eukaryotic neuroblastoma cellsTimo A. Lehti0Maria I. Pajunen1Maria S. Skog2Jukka Finne3Division of Biochemistry and Biotechnology, Department of Biosciences, University of Helsinki, P.O. Box 56Division of Biochemistry and Biotechnology, Department of Biosciences, University of Helsinki, P.O. Box 56Division of Biochemistry and Biotechnology, Department of Biosciences, University of Helsinki, P.O. Box 56Division of Biochemistry and Biotechnology, Department of Biosciences, University of Helsinki, P.O. Box 56Eukaryotic organisms are continuously exposed to bacteriophages, but these are not thought to enter non-phagocytic cells. Here, Lehti et al. show that a bacteriophage can bind to a specific receptor on the surface of human neuroblastoma cells in vitro, and be internalized via the endolysosomal route.https://doi.org/10.1038/s41467-017-02057-3
collection DOAJ
language English
format Article
sources DOAJ
author Timo A. Lehti
Maria I. Pajunen
Maria S. Skog
Jukka Finne
spellingShingle Timo A. Lehti
Maria I. Pajunen
Maria S. Skog
Jukka Finne
Internalization of a polysialic acid-binding Escherichia coli bacteriophage into eukaryotic neuroblastoma cells
Nature Communications
author_facet Timo A. Lehti
Maria I. Pajunen
Maria S. Skog
Jukka Finne
author_sort Timo A. Lehti
title Internalization of a polysialic acid-binding Escherichia coli bacteriophage into eukaryotic neuroblastoma cells
title_short Internalization of a polysialic acid-binding Escherichia coli bacteriophage into eukaryotic neuroblastoma cells
title_full Internalization of a polysialic acid-binding Escherichia coli bacteriophage into eukaryotic neuroblastoma cells
title_fullStr Internalization of a polysialic acid-binding Escherichia coli bacteriophage into eukaryotic neuroblastoma cells
title_full_unstemmed Internalization of a polysialic acid-binding Escherichia coli bacteriophage into eukaryotic neuroblastoma cells
title_sort internalization of a polysialic acid-binding escherichia coli bacteriophage into eukaryotic neuroblastoma cells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-12-01
description Eukaryotic organisms are continuously exposed to bacteriophages, but these are not thought to enter non-phagocytic cells. Here, Lehti et al. show that a bacteriophage can bind to a specific receptor on the surface of human neuroblastoma cells in vitro, and be internalized via the endolysosomal route.
url https://doi.org/10.1038/s41467-017-02057-3
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AT mariasskog internalizationofapolysialicacidbindingescherichiacolibacteriophageintoeukaryoticneuroblastomacells
AT jukkafinne internalizationofapolysialicacidbindingescherichiacolibacteriophageintoeukaryoticneuroblastomacells
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