Ketotifen Treatment of Active Colitis in Patients with 5-Aminosalicylate Intolerance

Ketotifen Treatment of Active Colitis in Patients with 5-Aminosalicylate Intolerance

Mast cell stabilizers are commonly used in the treatment of asthma and allergic disorders. Although the role of mucosal mast cells in the pathogenesis of inflammatory bowel disease remains uncertain, mast cell stabilizers have been shown in animal models to attenuate the severity of experimental col...

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Main Authors: John K Marshall, E Jan Irvine
Format: Article
Language:English
Published: Hindawi Limited 1998-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/1998/398142
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spelling doaj-9a87d2aa679248818b39d8ccfe1284542020-11-24T22:38:01ZengHindawi LimitedCanadian Journal of Gastroenterology0835-79001998-01-0112427327510.1155/1998/398142Ketotifen Treatment of Active Colitis in Patients with 5-Aminosalicylate IntoleranceJohn K Marshall0E Jan Irvine1Division of Gastroenterology, Department of Medicine, McMaster University, Hamilton, Ontario, CanadaDivision of Gastroenterology, Department of Medicine, McMaster University, Hamilton, Ontario, CanadaMast cell stabilizers are commonly used in the treatment of asthma and allergic disorders. Although the role of mucosal mast cells in the pathogenesis of inflammatory bowel disease remains uncertain, mast cell stabilizers have been shown in animal models to attenuate the severity of experimental colitis. The authors' experience with ketotifen in three patients - one each with Crohn's disease, ulcerative colitis and collagenous colitis - who had demonstrated allergy to, or intolerance of, 5-aminosalicylic acid is reported.http://dx.doi.org/10.1155/1998/398142
collection DOAJ
language English
format Article
sources DOAJ
author John K Marshall
E Jan Irvine
spellingShingle John K Marshall
E Jan Irvine
Ketotifen Treatment of Active Colitis in Patients with 5-Aminosalicylate Intolerance
Canadian Journal of Gastroenterology
author_facet John K Marshall
E Jan Irvine
author_sort John K Marshall
title Ketotifen Treatment of Active Colitis in Patients with 5-Aminosalicylate Intolerance
title_short Ketotifen Treatment of Active Colitis in Patients with 5-Aminosalicylate Intolerance
title_full Ketotifen Treatment of Active Colitis in Patients with 5-Aminosalicylate Intolerance
title_fullStr Ketotifen Treatment of Active Colitis in Patients with 5-Aminosalicylate Intolerance
title_full_unstemmed Ketotifen Treatment of Active Colitis in Patients with 5-Aminosalicylate Intolerance
title_sort ketotifen treatment of active colitis in patients with 5-aminosalicylate intolerance
publisher Hindawi Limited
series Canadian Journal of Gastroenterology
issn 0835-7900
publishDate 1998-01-01
description Mast cell stabilizers are commonly used in the treatment of asthma and allergic disorders. Although the role of mucosal mast cells in the pathogenesis of inflammatory bowel disease remains uncertain, mast cell stabilizers have been shown in animal models to attenuate the severity of experimental colitis. The authors' experience with ketotifen in three patients - one each with Crohn's disease, ulcerative colitis and collagenous colitis - who had demonstrated allergy to, or intolerance of, 5-aminosalicylic acid is reported.
url http://dx.doi.org/10.1155/1998/398142
work_keys_str_mv AT johnkmarshall ketotifentreatmentofactivecolitisinpatientswith5aminosalicylateintolerance
AT ejanirvine ketotifentreatmentofactivecolitisinpatientswith5aminosalicylateintolerance
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