The German trial on Aciclovir and Corticosteroids in Herpes-simplex-virus-Encephalitis (GACHE): a multicenter, randomized, double-blind, placebo-controlled trial

The German trial on Aciclovir and Corticosteroids in Herpes-simplex-virus-Encephalitis (GACHE): a multicenter, randomized, double-blind, placebo-controlled trial

Abstract Introduction Comprehensive treatment of Herpes-simplex-virus-encephalitis (HSVE) remains a major clinical challenge. The current therapy gold standard is aciclovir, a drug that inhibits viral replication. Despite antiviral treatment, mortality remains around 20% and a majority of survivors...

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Main Authors: U. Meyding-Lamadé, C. Jacobi, F. Martinez-Torres, T. Lenhard, B. Kress, M. Kieser, C. Klose, K. Einhäupl, J. Bösel, M-B Mackert, V. Homberg, C. Koennecke, G. Weißheit, D. Claus, B. Kieseier, J. Bardutzky, T. Neumann-Haefelin, M. W. Lorenz, H. Steinmetz, C. Gerloff, D. Schneider, A. Grau, M. Klein, R. Dziewas, U. Bogdahn, W. Jakob, R. Linker, K. Fuchs, A. Sander, S. Luntz, T. Hoppe-Tichy, D. F. Hanley, R. von Kummer, E. Craemer
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Neurological Research and Practice
Online Access:http://link.springer.com/article/10.1186/s42466-019-0031-3

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http://link.springer.com/article/10.1186/s42466-019-0031-3

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