Negative association between paraoxonase 2, anthropometric markers and metabolic syndrome
Background Metabolic syndrome (MS) has a great impact on cardiovascular mortality and morbidity. Our aim was to investigate the association of MS with some oxidant and antioxidant markers, including pro-and antioxidant status of peripheral blood mononuclear cells (PBMC) in newly diagnosed type 2 dia...
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doaj-9a95191375da4fe881f4452b2e88477f2020-11-24T23:56:08ZengDe GruyterOpen Life Sciences2391-54122015-08-0110110.1515/biol-2015-0037biol-2015-0037Negative association between paraoxonase 2, anthropometric markers and metabolic syndromeMihai Andrada0Lixandru Daniela1Alexandru Petruta2Stoian Irina3Carniciu Simona4Mitu Manuela5Guja Cristian6Ionescu-Tirgoviste Constantin7University of Medicine and Pharmacy “Carol Davila”, Bucharest, RomaniaUniversity of Medicine and Pharmacy “Carol Davila”, Bucharest, RomaniaUniversity of Medicine and Pharmacy “Carol Davila”, Bucharest, RomaniaUniversity of Medicine and Pharmacy “Carol Davila”, Bucharest, RomaniaUniversity of Medicine and Pharmacy “Carol Davila”, Bucharest, RomaniaUniversity of Medicine and Pharmacy “Carol Davila”, Bucharest, RomaniaUniversity of Medicine and Pharmacy “Carol Davila”, Bucharest, RomaniaUniversity of Medicine and Pharmacy “Carol Davila”, Bucharest, RomaniaBackground Metabolic syndrome (MS) has a great impact on cardiovascular mortality and morbidity. Our aim was to investigate the association of MS with some oxidant and antioxidant markers, including pro-and antioxidant status of peripheral blood mononuclear cells (PBMC) in newly diagnosed type 2 diabetic mellitus patients (ND-T2D). Methods 219 ND-T2D and 88 healthy subjects were divided in two groups according to the absence or presence of MS. Anthropometric measurements, routine blood tests, total oxidant status (TOS), total antioxidant status (TAS) and ELISA measurements were included. The PBMC capacity to release free radicals and to neutralize them was also determined by measuring the respiratory burst (RB) together with the lactonase activity of the intracellular antioxidant enzyme paraoxonase 2 (PON2). Results Comparing ND-T2D MS+ with those MS- the RB of the PBMC was significantly higher (p<0.05) while lactonase PON2 enzymatic activity was decreased (p < 0.001). A negative correlation of RB was found with TAS (r = -0.416, p < 0.05). PON2 was also negatively correlated with glycaemia (r = -0.275, p < 0.001), HbA1c (r = -0.308, p < 0.001), weight (r = -0.183; p < 0.05), waist circumference (r = -0.353, p < 0.001) and body mass index (r = -0.290, p < 0.001). Conclusion PON2 lactonase activity is negatively associated with anthropometric markers in ND-T2D with MS.http://www.degruyter.com/view/j/biol.2015.10.issue-1/biol-2015-0037/biol-2015-0037.xml?format=INTtype 2 diabetes metabolic syndrome paraoxonase 2 total oxidant and antioxidant status |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mihai Andrada Lixandru Daniela Alexandru Petruta Stoian Irina Carniciu Simona Mitu Manuela Guja Cristian Ionescu-Tirgoviste Constantin |
spellingShingle |
Mihai Andrada Lixandru Daniela Alexandru Petruta Stoian Irina Carniciu Simona Mitu Manuela Guja Cristian Ionescu-Tirgoviste Constantin Negative association between paraoxonase 2, anthropometric markers and metabolic syndrome Open Life Sciences type 2 diabetes metabolic syndrome paraoxonase 2 total oxidant and antioxidant status |
author_facet |
Mihai Andrada Lixandru Daniela Alexandru Petruta Stoian Irina Carniciu Simona Mitu Manuela Guja Cristian Ionescu-Tirgoviste Constantin |
author_sort |
Mihai Andrada |
title |
Negative association between paraoxonase 2,
anthropometric markers and metabolic syndrome |
title_short |
Negative association between paraoxonase 2,
anthropometric markers and metabolic syndrome |
title_full |
Negative association between paraoxonase 2,
anthropometric markers and metabolic syndrome |
title_fullStr |
Negative association between paraoxonase 2,
anthropometric markers and metabolic syndrome |
title_full_unstemmed |
Negative association between paraoxonase 2,
anthropometric markers and metabolic syndrome |
title_sort |
negative association between paraoxonase 2,
anthropometric markers and metabolic syndrome |
publisher |
De Gruyter |
series |
Open Life Sciences |
issn |
2391-5412 |
publishDate |
2015-08-01 |
description |
Background Metabolic syndrome (MS) has a great
impact on cardiovascular mortality and morbidity. Our aim
was to investigate the association of MS with some oxidant
and antioxidant markers, including pro-and antioxidant
status of peripheral blood mononuclear cells (PBMC) in
newly diagnosed type 2 diabetic mellitus patients (ND-T2D).
Methods 219 ND-T2D and 88 healthy subjects were divided
in two groups according to the absence or presence
of MS. Anthropometric measurements, routine blood
tests, total oxidant status (TOS), total antioxidant status
(TAS) and ELISA measurements were included. The
PBMC capacity to release free radicals and to neutralize
them was also determined by measuring the respiratory
burst (RB) together with the lactonase activity of the
intracellular antioxidant enzyme paraoxonase 2 (PON2).
Results Comparing ND-T2D MS+ with those MS- the RB of
the PBMC was significantly higher (p<0.05) while lactonase
PON2 enzymatic activity was decreased (p < 0.001). A
negative correlation of RB was found with TAS (r = -0.416, p
< 0.05). PON2 was also negatively correlated with glycaemia
(r = -0.275, p < 0.001), HbA1c (r = -0.308, p < 0.001), weight
(r = -0.183; p < 0.05), waist circumference (r = -0.353,
p < 0.001) and body mass index (r = -0.290, p < 0.001).
Conclusion PON2 lactonase activity is negatively associated
with anthropometric markers in ND-T2D with MS. |
topic |
type 2 diabetes metabolic syndrome paraoxonase 2 total oxidant and antioxidant status |
url |
http://www.degruyter.com/view/j/biol.2015.10.issue-1/biol-2015-0037/biol-2015-0037.xml?format=INT |
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