Comparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiography
Abstract Background The metabolic activity of retina is higher than other human tissues and is crucial to the vision. Cynomolgus macaques is widely used in ophthalmic disease research. The evaluation and comparison of macular and optic disc vascular circulation parameters between normal adult cynomo...
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doaj-9a99b2f3eff9463c929552fabc9acd1a2020-11-25T03:55:45ZengBMCBMC Ophthalmology1471-24152019-10-011911710.1186/s12886-019-1207-xComparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiographyJingyi Peng0Liuxueying Zhong1Li Ma2Jiayi Jin3Yongxin Zheng4Chenjin Jin5State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversityState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversityAbstract Background The metabolic activity of retina is higher than other human tissues and is crucial to the vision. Cynomolgus macaques is widely used in ophthalmic disease research. The evaluation and comparison of macular and optic disc vascular circulation parameters between normal adult cynomolgus macaques and healthy adult humans using OCT-A can promote better use of nonhuman primate models in studies of ophthalmic vascular disease. Methods Twelve normal adult cynomolgus macaques with a mean age of 4.91 ± 0.43 years were studied for data collection. The macula of 28 adult healthy humans (14 males and 14 females), with a mean age of 25.11 ± 6.21 years and the optic discs of 9 adult healthy humans (4 males and 5 females) with a mean age of 28.56 ± 6.78 years were measured. The vessel density (VD) was measured using an RTVue XR with AngioVue. The scan sizes of the macular and optic discs were 3 × 3 mm and 4.5 × 4.5 mm, respectively. Results OCT-A can image the superficial and deep capillary plexuses and radial peripapillary capillary network. In RPC layer of the optic disc, the VD in the nasal quadrant was lower than the VD in the inferior temporal quadrant. Similarities and significant differences in VD between healthy humans and cynomolgus macaques were obtained using OCT-A. Conclusions This study provides normal vascular parameters for adult cynomolgus macaques using OCT-A to help establish an optical parameter database for cynomolgus macaques and compare VD between healthy humans and cynomolgus macaques to promote choroid-retinopathy research. Trial registration Current Controlled Trials NCT03692169, retrospectively registered on 26 sept 2018.http://link.springer.com/article/10.1186/s12886-019-1207-xCynomolgus macaquesHealthy humansVascularOptical coherence tomography angiography (OCT-A)Vessel density (VD) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jingyi Peng Liuxueying Zhong Li Ma Jiayi Jin Yongxin Zheng Chenjin Jin |
spellingShingle |
Jingyi Peng Liuxueying Zhong Li Ma Jiayi Jin Yongxin Zheng Chenjin Jin Comparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiography BMC Ophthalmology Cynomolgus macaques Healthy humans Vascular Optical coherence tomography angiography (OCT-A) Vessel density (VD) |
author_facet |
Jingyi Peng Liuxueying Zhong Li Ma Jiayi Jin Yongxin Zheng Chenjin Jin |
author_sort |
Jingyi Peng |
title |
Comparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiography |
title_short |
Comparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiography |
title_full |
Comparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiography |
title_fullStr |
Comparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiography |
title_full_unstemmed |
Comparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiography |
title_sort |
comparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiography |
publisher |
BMC |
series |
BMC Ophthalmology |
issn |
1471-2415 |
publishDate |
2019-10-01 |
description |
Abstract Background The metabolic activity of retina is higher than other human tissues and is crucial to the vision. Cynomolgus macaques is widely used in ophthalmic disease research. The evaluation and comparison of macular and optic disc vascular circulation parameters between normal adult cynomolgus macaques and healthy adult humans using OCT-A can promote better use of nonhuman primate models in studies of ophthalmic vascular disease. Methods Twelve normal adult cynomolgus macaques with a mean age of 4.91 ± 0.43 years were studied for data collection. The macula of 28 adult healthy humans (14 males and 14 females), with a mean age of 25.11 ± 6.21 years and the optic discs of 9 adult healthy humans (4 males and 5 females) with a mean age of 28.56 ± 6.78 years were measured. The vessel density (VD) was measured using an RTVue XR with AngioVue. The scan sizes of the macular and optic discs were 3 × 3 mm and 4.5 × 4.5 mm, respectively. Results OCT-A can image the superficial and deep capillary plexuses and radial peripapillary capillary network. In RPC layer of the optic disc, the VD in the nasal quadrant was lower than the VD in the inferior temporal quadrant. Similarities and significant differences in VD between healthy humans and cynomolgus macaques were obtained using OCT-A. Conclusions This study provides normal vascular parameters for adult cynomolgus macaques using OCT-A to help establish an optical parameter database for cynomolgus macaques and compare VD between healthy humans and cynomolgus macaques to promote choroid-retinopathy research. Trial registration Current Controlled Trials NCT03692169, retrospectively registered on 26 sept 2018. |
topic |
Cynomolgus macaques Healthy humans Vascular Optical coherence tomography angiography (OCT-A) Vessel density (VD) |
url |
http://link.springer.com/article/10.1186/s12886-019-1207-x |
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