Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process Perspective
Three dimensional (3D) printing as an advanced manufacturing technology is progressing to be established in the pharmaceutical industry to overcome the traditional manufacturing regime of 'one size fits for all'. Using 3D printing, it is possible to design and develop complex dosage forms...
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doaj-9a9ebf1243c64520838b47d7df05cb282020-11-25T02:05:45ZengMDPI AGPharmaceutics1999-49232020-02-0112212410.3390/pharmaceutics12020124pharmaceutics12020124Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process PerspectiveMohammad A. Azad0Deborah Olawuni1Georgia Kimbell2Abu Zayed Md Badruddoza3Md. Shahadat Hossain4Tasnim Sultana5Department of Chemical, Biological and Bioengineering, North Carolina A&T State University, Greensboro, NC 27411, USADepartment of Chemical, Biological and Bioengineering, North Carolina A&T State University, Greensboro, NC 27411, USADepartment of Chemical, Biological and Bioengineering, North Carolina A&T State University, Greensboro, NC 27411, USADepartment of Chemical and Life Sciences Engineering, Virginia Commonwealth University, Richmond, VA 23284, USADepartment of Engineering Technology, Queensborough Community College, City University of New York (CUNY), Bayside, NY 11364, USADepartment of Public Health, School of Arts and Sciences, Massachusetts College of Pharmacy and Health Sciences (MCPHS), Boston, MA 02115, USAThree dimensional (3D) printing as an advanced manufacturing technology is progressing to be established in the pharmaceutical industry to overcome the traditional manufacturing regime of 'one size fits for all'. Using 3D printing, it is possible to design and develop complex dosage forms that can be suitable for tuning drug release. Polymers are the key materials that are necessary for 3D printing. Among all 3D printing processes, extrusion-based (both fused deposition modeling (FDM) and pressure-assisted microsyringe (PAM)) 3D printing is well researched for pharmaceutical manufacturing. It is important to understand which polymers are suitable for extrusion-based 3D printing of pharmaceuticals and how their properties, as well as the behavior of polymer−active pharmaceutical ingredient (API) combinations, impact the printing process. Especially, understanding the rheology of the polymer and API−polymer mixtures is necessary for successful 3D printing of dosage forms or printed structures. This review has summarized a holistic materials−process perspective for polymers on extrusion-based 3D printing. The main focus herein will be both FDM and PAM 3D printing processes. It elaborates the discussion on the comparison of 3D printing with the traditional direct compression process, the necessity of rheology, and the characterization techniques required for the printed structure, drug, and excipients. The current technological challenges, regulatory aspects, and the direction toward which the technology is moving, especially for personalized pharmaceuticals and multi-drug printing, are also briefly discussed.https://www.mdpi.com/1999-4923/12/2/124polymerspharmaceuticalsextrusion-based 3d printingfused deposition modeling (fdm)pressure-assisted microsyringe (pam)materialsprocess |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohammad A. Azad Deborah Olawuni Georgia Kimbell Abu Zayed Md Badruddoza Md. Shahadat Hossain Tasnim Sultana |
spellingShingle |
Mohammad A. Azad Deborah Olawuni Georgia Kimbell Abu Zayed Md Badruddoza Md. Shahadat Hossain Tasnim Sultana Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process Perspective Pharmaceutics polymers pharmaceuticals extrusion-based 3d printing fused deposition modeling (fdm) pressure-assisted microsyringe (pam) materials process |
author_facet |
Mohammad A. Azad Deborah Olawuni Georgia Kimbell Abu Zayed Md Badruddoza Md. Shahadat Hossain Tasnim Sultana |
author_sort |
Mohammad A. Azad |
title |
Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process Perspective |
title_short |
Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process Perspective |
title_full |
Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process Perspective |
title_fullStr |
Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process Perspective |
title_full_unstemmed |
Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process Perspective |
title_sort |
polymers for extrusion-based 3d printing of pharmaceuticals: a holistic materials–process perspective |
publisher |
MDPI AG |
series |
Pharmaceutics |
issn |
1999-4923 |
publishDate |
2020-02-01 |
description |
Three dimensional (3D) printing as an advanced manufacturing technology is progressing to be established in the pharmaceutical industry to overcome the traditional manufacturing regime of 'one size fits for all'. Using 3D printing, it is possible to design and develop complex dosage forms that can be suitable for tuning drug release. Polymers are the key materials that are necessary for 3D printing. Among all 3D printing processes, extrusion-based (both fused deposition modeling (FDM) and pressure-assisted microsyringe (PAM)) 3D printing is well researched for pharmaceutical manufacturing. It is important to understand which polymers are suitable for extrusion-based 3D printing of pharmaceuticals and how their properties, as well as the behavior of polymer−active pharmaceutical ingredient (API) combinations, impact the printing process. Especially, understanding the rheology of the polymer and API−polymer mixtures is necessary for successful 3D printing of dosage forms or printed structures. This review has summarized a holistic materials−process perspective for polymers on extrusion-based 3D printing. The main focus herein will be both FDM and PAM 3D printing processes. It elaborates the discussion on the comparison of 3D printing with the traditional direct compression process, the necessity of rheology, and the characterization techniques required for the printed structure, drug, and excipients. The current technological challenges, regulatory aspects, and the direction toward which the technology is moving, especially for personalized pharmaceuticals and multi-drug printing, are also briefly discussed. |
topic |
polymers pharmaceuticals extrusion-based 3d printing fused deposition modeling (fdm) pressure-assisted microsyringe (pam) materials process |
url |
https://www.mdpi.com/1999-4923/12/2/124 |
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