Portal vein innervation underlying the pressor effect of water ingestion with and without cold stress
Water-induced pressor response appears mediated through the activation of transient receptor potential channel TRPV4 on hepatic portal circulation in animals. We sought to elucidate the mechanism of portal vein signaling in this response. Forty-five rats were divided into four groups: control rats w...
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2020-01-01
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doaj-9aa6ed9863c349bd81d0fbaa259e70a52021-04-20T08:41:13ZengWolters Kluwer Medknow PublicationsChinese Journal of Physiology0304-49202666-00592020-01-01632535910.4103/CJP.CJP_96_19Portal vein innervation underlying the pressor effect of water ingestion with and without cold stressShi-Hung TsaiJou-Yu LinYu-Chieh LinYia-Ping LiuChe-Se TungWater-induced pressor response appears mediated through the activation of transient receptor potential channel TRPV4 on hepatic portal circulation in animals. We sought to elucidate the mechanism of portal vein signaling in this response. Forty-five rats were divided into four groups: control rats without water ingestion (WI), control rats with WI, portal vein denervation rats with WI (PVDWI), and TRPV4 antagonist-treated rats with WI (anti-TRPV4WI). Cardiovascular responses were monitored throughout the experiments. Data analysis was performed using descriptive methods and spectral and cross-spectral analysis of blood pressure variability (BPV) and heart rate variability (HRV). Key results showed that at baseline (PreCS) before cold stress trial (CS), WI elicited robust pressor and tachycardia responses accompanied by spectral power changes, in particular, increases of low-frequency BPV (LFBPV) and very-LFBPV (VLFBPV), but decrease of very-low-frequency HRV. PVDWI, likewise, elicited pressor and tachycardia responses accompanied by increases of high-frequency BPV, high-frequency HRV, LFBPV, low-frequency HRV, and VLFBPV. When compared with WI at PreCS, WI at CS elicited pressor and tachycardia responses accompanied by increases of high-frequency BPV, LFBPV, and VLFBPV, whereas in WI, the CS-evoked pressor response and the accompanied LFBPV and VLFBPV increases were all tended augmented by PVDWI. When compared with WI and PVDWI at both PreCS and CS, however, anti-TRPV4WI attenuated their pressor responses and attenuated their increased LFBPV, VLFBPV, and very-low-frequency HRV. The results indicate that the portal vein innervation is critical for a buffering mechanism in splanchnic sympathetic activation and water-induced pressor response.http://www.cjphysiology.org/article.asp?issn=0304-4920;year=2020;volume=63;issue=2;spage=53;epage=59;aulast=Tsaiblood pressure variabilitycold stressheart rate variabilityportal vein denervationtrpv4water ingestion |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shi-Hung Tsai Jou-Yu Lin Yu-Chieh Lin Yia-Ping Liu Che-Se Tung |
spellingShingle |
Shi-Hung Tsai Jou-Yu Lin Yu-Chieh Lin Yia-Ping Liu Che-Se Tung Portal vein innervation underlying the pressor effect of water ingestion with and without cold stress Chinese Journal of Physiology blood pressure variability cold stress heart rate variability portal vein denervation trpv4 water ingestion |
author_facet |
Shi-Hung Tsai Jou-Yu Lin Yu-Chieh Lin Yia-Ping Liu Che-Se Tung |
author_sort |
Shi-Hung Tsai |
title |
Portal vein innervation underlying the pressor effect of water ingestion with and without cold stress |
title_short |
Portal vein innervation underlying the pressor effect of water ingestion with and without cold stress |
title_full |
Portal vein innervation underlying the pressor effect of water ingestion with and without cold stress |
title_fullStr |
Portal vein innervation underlying the pressor effect of water ingestion with and without cold stress |
title_full_unstemmed |
Portal vein innervation underlying the pressor effect of water ingestion with and without cold stress |
title_sort |
portal vein innervation underlying the pressor effect of water ingestion with and without cold stress |
publisher |
Wolters Kluwer Medknow Publications |
series |
Chinese Journal of Physiology |
issn |
0304-4920 2666-0059 |
publishDate |
2020-01-01 |
description |
Water-induced pressor response appears mediated through the activation of transient receptor potential channel TRPV4 on hepatic portal circulation in animals. We sought to elucidate the mechanism of portal vein signaling in this response. Forty-five rats were divided into four groups: control rats without water ingestion (WI), control rats with WI, portal vein denervation rats with WI (PVDWI), and TRPV4 antagonist-treated rats with WI (anti-TRPV4WI). Cardiovascular responses were monitored throughout the experiments. Data analysis was performed using descriptive methods and spectral and cross-spectral analysis of blood pressure variability (BPV) and heart rate variability (HRV). Key results showed that at baseline (PreCS) before cold stress trial (CS), WI elicited robust pressor and tachycardia responses accompanied by spectral power changes, in particular, increases of low-frequency BPV (LFBPV) and very-LFBPV (VLFBPV), but decrease of very-low-frequency HRV. PVDWI, likewise, elicited pressor and tachycardia responses accompanied by increases of high-frequency BPV, high-frequency HRV, LFBPV, low-frequency HRV, and VLFBPV. When compared with WI at PreCS, WI at CS elicited pressor and tachycardia responses accompanied by increases of high-frequency BPV, LFBPV, and VLFBPV, whereas in WI, the CS-evoked pressor response and the accompanied LFBPV and VLFBPV increases were all tended augmented by PVDWI. When compared with WI and PVDWI at both PreCS and CS, however, anti-TRPV4WI attenuated their pressor responses and attenuated their increased LFBPV, VLFBPV, and very-low-frequency HRV. The results indicate that the portal vein innervation is critical for a buffering mechanism in splanchnic sympathetic activation and water-induced pressor response. |
topic |
blood pressure variability cold stress heart rate variability portal vein denervation trpv4 water ingestion |
url |
http://www.cjphysiology.org/article.asp?issn=0304-4920;year=2020;volume=63;issue=2;spage=53;epage=59;aulast=Tsai |
work_keys_str_mv |
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