Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection

Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) methods can non-invasively assess brown adipose tissue (BAT) structure and function. Recently, MRI and MRS have been proposed as a means to differentiate BAT from white adipose tissue (WAT) and to extract morphological and fu...

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Main Authors: Mingming Wu, Daniela Junker, Rosa Tamara Branca, Dimitrios C. Karampinos
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Endocrinology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00421/full
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spelling doaj-9abb532fea1d42959fbf1665ab3bf8642020-11-25T03:10:59ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-08-011110.3389/fendo.2020.00421540707Magnetic Resonance Imaging Techniques for Brown Adipose Tissue DetectionMingming Wu0Daniela Junker1Rosa Tamara Branca2Dimitrios C. Karampinos3Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, GermanyDepartment of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, GermanyDepartment of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesDepartment of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, GermanyMagnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) methods can non-invasively assess brown adipose tissue (BAT) structure and function. Recently, MRI and MRS have been proposed as a means to differentiate BAT from white adipose tissue (WAT) and to extract morphological and functional information on BAT inaccessible by other means. Specifically, proton MR (1H) techniques, such as proton density fat fraction mapping, diffusion imaging, and intermolecular multiple quantum coherence imaging, have been employed to access BAT microstructure; MR thermometry, relaxometry, and MRI and MRS with 31P, 2H, 13C, and 129Xe have shown to provide complementary information on BAT function. The purpose of the present review is to provide a comprehensive overview of MR imaging and spectroscopy techniques used to detect BAT in rodents and in humans. The present work discusses common challenges of current methods and provides an outlook on possible future directions of using MRI and MRS in BAT studies.https://www.frontiersin.org/article/10.3389/fendo.2020.00421/fullbrown adipose tissue (BAT)white adipose tissue (WAT)magnetic resonance imagingmagnetic resonance spectroscopymorphologyactivation
collection DOAJ
language English
format Article
sources DOAJ
author Mingming Wu
Daniela Junker
Rosa Tamara Branca
Dimitrios C. Karampinos
spellingShingle Mingming Wu
Daniela Junker
Rosa Tamara Branca
Dimitrios C. Karampinos
Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection
Frontiers in Endocrinology
brown adipose tissue (BAT)
white adipose tissue (WAT)
magnetic resonance imaging
magnetic resonance spectroscopy
morphology
activation
author_facet Mingming Wu
Daniela Junker
Rosa Tamara Branca
Dimitrios C. Karampinos
author_sort Mingming Wu
title Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection
title_short Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection
title_full Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection
title_fullStr Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection
title_full_unstemmed Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection
title_sort magnetic resonance imaging techniques for brown adipose tissue detection
publisher Frontiers Media S.A.
series Frontiers in Endocrinology
issn 1664-2392
publishDate 2020-08-01
description Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) methods can non-invasively assess brown adipose tissue (BAT) structure and function. Recently, MRI and MRS have been proposed as a means to differentiate BAT from white adipose tissue (WAT) and to extract morphological and functional information on BAT inaccessible by other means. Specifically, proton MR (1H) techniques, such as proton density fat fraction mapping, diffusion imaging, and intermolecular multiple quantum coherence imaging, have been employed to access BAT microstructure; MR thermometry, relaxometry, and MRI and MRS with 31P, 2H, 13C, and 129Xe have shown to provide complementary information on BAT function. The purpose of the present review is to provide a comprehensive overview of MR imaging and spectroscopy techniques used to detect BAT in rodents and in humans. The present work discusses common challenges of current methods and provides an outlook on possible future directions of using MRI and MRS in BAT studies.
topic brown adipose tissue (BAT)
white adipose tissue (WAT)
magnetic resonance imaging
magnetic resonance spectroscopy
morphology
activation
url https://www.frontiersin.org/article/10.3389/fendo.2020.00421/full
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AT rosatamarabranca magneticresonanceimagingtechniquesforbrownadiposetissuedetection
AT dimitriosckarampinos magneticresonanceimagingtechniquesforbrownadiposetissuedetection
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