Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection
Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) methods can non-invasively assess brown adipose tissue (BAT) structure and function. Recently, MRI and MRS have been proposed as a means to differentiate BAT from white adipose tissue (WAT) and to extract morphological and fu...
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doaj-9abb532fea1d42959fbf1665ab3bf8642020-11-25T03:10:59ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-08-011110.3389/fendo.2020.00421540707Magnetic Resonance Imaging Techniques for Brown Adipose Tissue DetectionMingming Wu0Daniela Junker1Rosa Tamara Branca2Dimitrios C. Karampinos3Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, GermanyDepartment of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, GermanyDepartment of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesDepartment of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, GermanyMagnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) methods can non-invasively assess brown adipose tissue (BAT) structure and function. Recently, MRI and MRS have been proposed as a means to differentiate BAT from white adipose tissue (WAT) and to extract morphological and functional information on BAT inaccessible by other means. Specifically, proton MR (1H) techniques, such as proton density fat fraction mapping, diffusion imaging, and intermolecular multiple quantum coherence imaging, have been employed to access BAT microstructure; MR thermometry, relaxometry, and MRI and MRS with 31P, 2H, 13C, and 129Xe have shown to provide complementary information on BAT function. The purpose of the present review is to provide a comprehensive overview of MR imaging and spectroscopy techniques used to detect BAT in rodents and in humans. The present work discusses common challenges of current methods and provides an outlook on possible future directions of using MRI and MRS in BAT studies.https://www.frontiersin.org/article/10.3389/fendo.2020.00421/fullbrown adipose tissue (BAT)white adipose tissue (WAT)magnetic resonance imagingmagnetic resonance spectroscopymorphologyactivation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mingming Wu Daniela Junker Rosa Tamara Branca Dimitrios C. Karampinos |
spellingShingle |
Mingming Wu Daniela Junker Rosa Tamara Branca Dimitrios C. Karampinos Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection Frontiers in Endocrinology brown adipose tissue (BAT) white adipose tissue (WAT) magnetic resonance imaging magnetic resonance spectroscopy morphology activation |
author_facet |
Mingming Wu Daniela Junker Rosa Tamara Branca Dimitrios C. Karampinos |
author_sort |
Mingming Wu |
title |
Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection |
title_short |
Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection |
title_full |
Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection |
title_fullStr |
Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection |
title_full_unstemmed |
Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection |
title_sort |
magnetic resonance imaging techniques for brown adipose tissue detection |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Endocrinology |
issn |
1664-2392 |
publishDate |
2020-08-01 |
description |
Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) methods can non-invasively assess brown adipose tissue (BAT) structure and function. Recently, MRI and MRS have been proposed as a means to differentiate BAT from white adipose tissue (WAT) and to extract morphological and functional information on BAT inaccessible by other means. Specifically, proton MR (1H) techniques, such as proton density fat fraction mapping, diffusion imaging, and intermolecular multiple quantum coherence imaging, have been employed to access BAT microstructure; MR thermometry, relaxometry, and MRI and MRS with 31P, 2H, 13C, and 129Xe have shown to provide complementary information on BAT function. The purpose of the present review is to provide a comprehensive overview of MR imaging and spectroscopy techniques used to detect BAT in rodents and in humans. The present work discusses common challenges of current methods and provides an outlook on possible future directions of using MRI and MRS in BAT studies. |
topic |
brown adipose tissue (BAT) white adipose tissue (WAT) magnetic resonance imaging magnetic resonance spectroscopy morphology activation |
url |
https://www.frontiersin.org/article/10.3389/fendo.2020.00421/full |
work_keys_str_mv |
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