The Emerging Roles of Exosomes as EMT Regulators in Cancer
Epithelial–mesenchymal transition (EMT) causes epithelial cells to lose their polarity and adhesion property, and endows them with migratory and invasive properties to enable them to become mesenchymal stem cells. EMT occurs throughout embryonic development, during wound healing, and in various path...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-04-01
|
Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/9/4/861 |
id |
doaj-9abc9f61e3254b8c8d394ec2fc21f7ad |
---|---|
record_format |
Article |
spelling |
doaj-9abc9f61e3254b8c8d394ec2fc21f7ad2020-11-25T02:21:57ZengMDPI AGCells2073-44092020-04-01986186110.3390/cells9040861The Emerging Roles of Exosomes as EMT Regulators in CancerHyunwoo Kim0Sungmin Lee1Eunguk Shin2Ki Moon Seong3Young Woo Jin4HyeSook Youn5BuHyun Youn6Department of Integrated Biological Science, Pusan National University, Busan 46241, KoreaDepartment of Integrated Biological Science, Pusan National University, Busan 46241, KoreaDepartment of Integrated Biological Science, Pusan National University, Busan 46241, KoreaLaboratory of Low Dose Risk Assessment, National Radiation Emergency Medical Center, Korea Institute of Radiological & Medical Sciences, Seoul 01812, KoreaLaboratory of Low Dose Risk Assessment, National Radiation Emergency Medical Center, Korea Institute of Radiological & Medical Sciences, Seoul 01812, KoreaDepartment of Integrative Bioscience and Biotechnology, Sejong University, Seoul 05006, KoreaDepartment of Integrated Biological Science, Pusan National University, Busan 46241, KoreaEpithelial–mesenchymal transition (EMT) causes epithelial cells to lose their polarity and adhesion property, and endows them with migratory and invasive properties to enable them to become mesenchymal stem cells. EMT occurs throughout embryonic development, during wound healing, and in various pathological processes, including tumor progression. Considerable research in the last few decades has revealed that EMT is invariably related to tumor aggressiveness and metastasis. Apart from the interactions between numerous intracellular signaling pathways known to regulate EMT, extracellular modulators in the tumor microenvironment also influence tumor cells to undergo EMT, with extracellular vesicles (EVs) receiving increasing attention as EMT inducers. EVs comprise exosomes and microvesicles that carry proteins, nucleic acids, lipids, and other small molecules to stimulate EMT in cells. Among EVs, exosomes have been investigated in many studies, and their role has been found to be significant with respect to regulating intercellular communications. In this review, we summarize recent studies on exosomes and their cargoes that induce cancer-associated EMT. Furthermore, we describe the possible applications of exosomes as promising therapeutic strategies.https://www.mdpi.com/2073-4409/9/4/861Epithelial mesenchymal transitionExosomeCancerWnt/β-catenin pathwayHippo pathway |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hyunwoo Kim Sungmin Lee Eunguk Shin Ki Moon Seong Young Woo Jin HyeSook Youn BuHyun Youn |
spellingShingle |
Hyunwoo Kim Sungmin Lee Eunguk Shin Ki Moon Seong Young Woo Jin HyeSook Youn BuHyun Youn The Emerging Roles of Exosomes as EMT Regulators in Cancer Cells Epithelial mesenchymal transition Exosome Cancer Wnt/β-catenin pathway Hippo pathway |
author_facet |
Hyunwoo Kim Sungmin Lee Eunguk Shin Ki Moon Seong Young Woo Jin HyeSook Youn BuHyun Youn |
author_sort |
Hyunwoo Kim |
title |
The Emerging Roles of Exosomes as EMT Regulators in Cancer |
title_short |
The Emerging Roles of Exosomes as EMT Regulators in Cancer |
title_full |
The Emerging Roles of Exosomes as EMT Regulators in Cancer |
title_fullStr |
The Emerging Roles of Exosomes as EMT Regulators in Cancer |
title_full_unstemmed |
The Emerging Roles of Exosomes as EMT Regulators in Cancer |
title_sort |
emerging roles of exosomes as emt regulators in cancer |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2020-04-01 |
description |
Epithelial–mesenchymal transition (EMT) causes epithelial cells to lose their polarity and adhesion property, and endows them with migratory and invasive properties to enable them to become mesenchymal stem cells. EMT occurs throughout embryonic development, during wound healing, and in various pathological processes, including tumor progression. Considerable research in the last few decades has revealed that EMT is invariably related to tumor aggressiveness and metastasis. Apart from the interactions between numerous intracellular signaling pathways known to regulate EMT, extracellular modulators in the tumor microenvironment also influence tumor cells to undergo EMT, with extracellular vesicles (EVs) receiving increasing attention as EMT inducers. EVs comprise exosomes and microvesicles that carry proteins, nucleic acids, lipids, and other small molecules to stimulate EMT in cells. Among EVs, exosomes have been investigated in many studies, and their role has been found to be significant with respect to regulating intercellular communications. In this review, we summarize recent studies on exosomes and their cargoes that induce cancer-associated EMT. Furthermore, we describe the possible applications of exosomes as promising therapeutic strategies. |
topic |
Epithelial mesenchymal transition Exosome Cancer Wnt/β-catenin pathway Hippo pathway |
url |
https://www.mdpi.com/2073-4409/9/4/861 |
work_keys_str_mv |
AT hyunwookim theemergingrolesofexosomesasemtregulatorsincancer AT sungminlee theemergingrolesofexosomesasemtregulatorsincancer AT eungukshin theemergingrolesofexosomesasemtregulatorsincancer AT kimoonseong theemergingrolesofexosomesasemtregulatorsincancer AT youngwoojin theemergingrolesofexosomesasemtregulatorsincancer AT hyesookyoun theemergingrolesofexosomesasemtregulatorsincancer AT buhyunyoun theemergingrolesofexosomesasemtregulatorsincancer AT hyunwookim emergingrolesofexosomesasemtregulatorsincancer AT sungminlee emergingrolesofexosomesasemtregulatorsincancer AT eungukshin emergingrolesofexosomesasemtregulatorsincancer AT kimoonseong emergingrolesofexosomesasemtregulatorsincancer AT youngwoojin emergingrolesofexosomesasemtregulatorsincancer AT hyesookyoun emergingrolesofexosomesasemtregulatorsincancer AT buhyunyoun emergingrolesofexosomesasemtregulatorsincancer |
_version_ |
1724864324737957888 |