New Approaches to Blockade of the Renin–Angiotensin–Aldosterone System: Chymase as an Important Target to Prevent Organ Damage
Chymase plays a crucial role in angiotensin II formation in various tissues. Angiotensin II induces gene expression of transforming growth factor (TGF)-β and matrix metalloproteinase (MMP)-9 precursors, and chymase can convert precursors of TGF-β and MMP-9 to their active forms. In cultured fibrobla...
Main Authors: | Shinji Takai, Denan Jin, Mizuo Miyazaki |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2010-01-01
|
Series: | Journal of Pharmacological Sciences |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319308965 |
Similar Items
-
Tissue Angiotensin II Generating System by Angiotensin-Converting Enzyme and Chymase
by: Mizuo Miyazaki, et al.
Published: (2006-01-01) -
Multiple Mechanisms for the Action of Chymase Inhibitors
by: Shinji Takai, et al.
Published: (2012-01-01) -
Role of chymase on vascular proliferation
by: Mizuo Miyazaki, et al.
Published: (2000-03-01) -
A Single Treatment With a Specific Chymase Inhibitor, TY-51184, Prevents Vascular Proliferation in Canine Grafted Veins
by: Shinji Takai, et al.
Published: (2004-01-01) -
New Approaches to Blockade of the Renin–Angiotensin–Aldosterone System: Overview of Regulation of the Renin–Angiotensin–Aldosterone System
by: Akira Nishiyama, et al.
Published: (2010-01-01)