Cellular Senescence and Senotherapies in the Kidney: Current Evidence and Future Directions

Cellular senescence refers to a cellular phenotype characterized by an altered transcriptome, pro-inflammatory secretome, and generally irreversible growth arrest. Acutely senescent cells are widely recognized as performing key physiological functions in vivo promoting normal organogenesis, successf...

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Bibliographic Details
Main Authors: Marie Helena Docherty, David P. Baird, Jeremy Hughes, David A. Ferenbach
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00755/full