Fixed combinations in the management of hypertension: perspectives on lercanidipine – enalapril
Vivencio Barrios1, Carlos Escobar2, Rocio Echarri31Department of Cardiology, Hospital Ramón y Cajal, Madrid; 2Department of Cardiology, Hospital Infanta Sofia, Madrid, 3Department of Nephrology, Hospital Infanta Sofia, MadridAbstract: Although achieving blood pressure (BP) control is crit...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Dove Medical Press
2008-08-01
|
Series: | Vascular Health and Risk Management |
Subjects: | |
Online Access: | https://www.dovepress.com/fixed-combinations-in-the-management-of-hypertension-perspectives-on-l-peer-reviewed-article-VHRM |
id |
doaj-9ae68c0508b747e1984e072faea00c11 |
---|---|
record_format |
Article |
spelling |
doaj-9ae68c0508b747e1984e072faea00c112020-11-25T01:26:12ZengDove Medical PressVascular Health and Risk Management1178-20482008-08-01Volume 48478532172Fixed combinations in the management of hypertension: perspectives on lercanidipine – enalaprilVivencio BarriosCarlos EscobarRocio EcharriVivencio Barrios1, Carlos Escobar2, Rocio Echarri31Department of Cardiology, Hospital Ramón y Cajal, Madrid; 2Department of Cardiology, Hospital Infanta Sofia, Madrid, 3Department of Nephrology, Hospital Infanta Sofia, MadridAbstract: Although achieving blood pressure (BP) control is critical to improve cardiovascular prognosis in hypertensive patients, many of them fail to achieve BP goals. The majority of hypertensive patients need more than one antihypertensive agent to attain BP targets. Combination therapy is required when monotherapy fails to attain BP objectives and as a first-line treatment in certain situations, such as markedly elevated BP values, when lower targets are required in high or very high cardiovascular risk patients. The advantages of combination therapy are well documented, with an increased antihypertensive efficacy as a result of the simultaneous inhibition of different mechanisms of action and with a lesser incidence of adverse events, because of the possible compensatory responses and the lower doses used. Calcium channel blockers are effective drugs in the treatment of hypertension. The efficacy of lercanidipine has been evaluated in several noncomparative and in comparative studies showing a great efficacy with a good tolerability. On the other hand, the inhibition of the renin-angiotensin system appears to be very beneficial in the treatment of patients with hypertension. Enalapril is an effective and well tolerated angiotensin converting enzyme inhibitor. Although there are several fixed-combination drugs, the combination lercanidipine plus enalapril appears to be one of the most promising therapies in the treatment of hypertension. The aim of this manuscript is to update the published data about the efficacy and safety of this fixed combination.Keywords: angiotensin converting enzyme inhibitors, calcium channel blockers, combination therapy, hypertension, lercanidipine, enalaprilhttps://www.dovepress.com/fixed-combinations-in-the-management-of-hypertension-perspectives-on-l-peer-reviewed-article-VHRMangiotensin converting enzyme inhibitorscalcium channel blockerscombination therapyhypertensionlercanidipineenalapril. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vivencio Barrios Carlos Escobar Rocio Echarri |
spellingShingle |
Vivencio Barrios Carlos Escobar Rocio Echarri Fixed combinations in the management of hypertension: perspectives on lercanidipine – enalapril Vascular Health and Risk Management angiotensin converting enzyme inhibitors calcium channel blockers combination therapy hypertension lercanidipine enalapril. |
author_facet |
Vivencio Barrios Carlos Escobar Rocio Echarri |
author_sort |
Vivencio Barrios |
title |
Fixed combinations in the management of hypertension: perspectives on lercanidipine – enalapril |
title_short |
Fixed combinations in the management of hypertension: perspectives on lercanidipine – enalapril |
title_full |
Fixed combinations in the management of hypertension: perspectives on lercanidipine – enalapril |
title_fullStr |
Fixed combinations in the management of hypertension: perspectives on lercanidipine – enalapril |
title_full_unstemmed |
Fixed combinations in the management of hypertension: perspectives on lercanidipine – enalapril |
title_sort |
fixed combinations in the management of hypertension: perspectives on lercanidipine – enalapril |
publisher |
Dove Medical Press |
series |
Vascular Health and Risk Management |
issn |
1178-2048 |
publishDate |
2008-08-01 |
description |
Vivencio Barrios1, Carlos Escobar2, Rocio Echarri31Department of Cardiology, Hospital Ramón y Cajal, Madrid; 2Department of Cardiology, Hospital Infanta Sofia, Madrid, 3Department of Nephrology, Hospital Infanta Sofia, MadridAbstract: Although achieving blood pressure (BP) control is critical to improve cardiovascular prognosis in hypertensive patients, many of them fail to achieve BP goals. The majority of hypertensive patients need more than one antihypertensive agent to attain BP targets. Combination therapy is required when monotherapy fails to attain BP objectives and as a first-line treatment in certain situations, such as markedly elevated BP values, when lower targets are required in high or very high cardiovascular risk patients. The advantages of combination therapy are well documented, with an increased antihypertensive efficacy as a result of the simultaneous inhibition of different mechanisms of action and with a lesser incidence of adverse events, because of the possible compensatory responses and the lower doses used. Calcium channel blockers are effective drugs in the treatment of hypertension. The efficacy of lercanidipine has been evaluated in several noncomparative and in comparative studies showing a great efficacy with a good tolerability. On the other hand, the inhibition of the renin-angiotensin system appears to be very beneficial in the treatment of patients with hypertension. Enalapril is an effective and well tolerated angiotensin converting enzyme inhibitor. Although there are several fixed-combination drugs, the combination lercanidipine plus enalapril appears to be one of the most promising therapies in the treatment of hypertension. The aim of this manuscript is to update the published data about the efficacy and safety of this fixed combination.Keywords: angiotensin converting enzyme inhibitors, calcium channel blockers, combination therapy, hypertension, lercanidipine, enalapril |
topic |
angiotensin converting enzyme inhibitors calcium channel blockers combination therapy hypertension lercanidipine enalapril. |
url |
https://www.dovepress.com/fixed-combinations-in-the-management-of-hypertension-perspectives-on-l-peer-reviewed-article-VHRM |
work_keys_str_mv |
AT vivenciobarrios fixedcombinationsinthemanagementofhypertensionperspectivesonlercanidipinendashenalapril AT carlosescobar fixedcombinationsinthemanagementofhypertensionperspectivesonlercanidipinendashenalapril AT rocioecharri fixedcombinationsinthemanagementofhypertensionperspectivesonlercanidipinendashenalapril |
_version_ |
1725110266557890560 |