Whole-Genome Sequencing of Invasion-Resistant Cells Identifies Laminin α2 as a Host Factor for Bacterial Invasion
To understand the role of glycosaminoglycans in bacterial cellular invasion, xylosyltransferase-deficient mutants of Chinese hamster ovary (CHO) cells were created using clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-associated gene 9 (CRISPR-cas9) gene targeting. When...
Main Authors: | Xander M. van Wijk, Simon Dohrmann, Bjorn M. Hallstrom, Shangzhong Li, Bjørn G. Voldborg, Brandon X. Meng, Karen K. McKee, Toin H. van Kuppevelt, Peter D. Yurchenco, Bernhard O. Palsson, Nathan E. Lewis, Victor Nizet, Jeffrey D. Esko, Pyong Park, Gerald B. Pier |
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Format: | Article |
Language: | English |
Published: |
American Society for Microbiology
2017-01-01
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Series: | mBio |
Online Access: | http://mbio.asm.org/cgi/content/full/8/1/e02128-16 |
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