Rare Forms of Lipomatosis: Dercum’s Disease and Roch-Leri Mesosomatous Lipomatosis
In contrast to obesity, which is very frequent, lipomatosis and lipodystrophy syndromes are rare diseases of adipose tissue. Lipodystrophy syndromes are characterized by metabolic abnormalities associated with partial or generalized lipoatrophy. Lipomatosis is defined by the presence of several body...
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doaj-9aef2d066845450f96e97b39edc2f51a2021-03-22T00:00:31ZengMDPI AGJournal of Clinical Medicine2077-03832021-03-01101292129210.3390/jcm10061292Rare Forms of Lipomatosis: Dercum’s Disease and Roch-Leri Mesosomatous LipomatosisMadleen Lemaitre0Sebastien Aubert1Benjamin Chevalier2Arnaud Jannin3Julien Bourry4Gaetan Prévost5Herve Lefebvre6Marie-Christine Vantyghem7Endocrinology, Diabetology and Metabolism, CHU Lille, F-59000 Lille, FranceDepartment of Biopathology, CHU Lille, F-59000 Lille, FranceEndocrinology, Diabetology and Metabolism, CHU Lille, F-59000 Lille, FranceEndocrinology, Diabetology and Metabolism, CHU Lille, F-59000 Lille, FranceEndocrinology, Diabetology and Metabolism, CHU Lille, F-59000 Lille, FranceDepartment of Endocrinology, Diabetes and Metabolic Diseases, Rouen University Hospital, 76000 Rouen, FranceDepartment of Endocrinology, Diabetes and Metabolic Diseases, Rouen University Hospital, 76000 Rouen, FranceEndocrinology, Diabetology and Metabolism, CHU Lille, F-59000 Lille, FranceIn contrast to obesity, which is very frequent, lipomatosis and lipodystrophy syndromes are rare diseases of adipose tissue. Lipodystrophy syndromes are characterized by metabolic abnormalities associated with partial or generalized lipoatrophy. Lipomatosis is defined by the presence of several body lipomas without lipoatrophy. Dercum’s disease (DD) and Roch-Leri mesosomatous lipomatosis (RLML) are rare and poorly characterized forms of lipomatosis. They have raised little clinical interest despite the non-negligible consequences of DD on quality of life. The main clinical presentation of these diseases includes multiple lipomas, which are painful in DD (in contrast to RLML). The two diseases are frequently associated with obesity and metabolic syndrome, with hypertension, diabetes, or dyslipidemia. The long-term course of the diseases remains poorly described. DD affects mainly women, whereas RLML mostly affects men. In both diseases lipomas are found on the back and thighs, as well as on the abdomen in DD and the forearms in RLML. The painful lipomas tend to recur after surgery in DD (in contrast to RLML). Most cases are sporadic. No specific treatment has been identified, as the pathophysiology remains unknown. Nevertheless, low-grade fat inflammation and specific abnormalities such as hyperbasophilia deserve further investigation. The aim of this review is to analyze the available literature on the topic.https://www.mdpi.com/2077-0383/10/6/1292lipodystrophyDercum’s diseaseRoch-Leri mesosomatous lipomatosislipomatosisadipose tissue |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Madleen Lemaitre Sebastien Aubert Benjamin Chevalier Arnaud Jannin Julien Bourry Gaetan Prévost Herve Lefebvre Marie-Christine Vantyghem |
spellingShingle |
Madleen Lemaitre Sebastien Aubert Benjamin Chevalier Arnaud Jannin Julien Bourry Gaetan Prévost Herve Lefebvre Marie-Christine Vantyghem Rare Forms of Lipomatosis: Dercum’s Disease and Roch-Leri Mesosomatous Lipomatosis Journal of Clinical Medicine lipodystrophy Dercum’s disease Roch-Leri mesosomatous lipomatosis lipomatosis adipose tissue |
author_facet |
Madleen Lemaitre Sebastien Aubert Benjamin Chevalier Arnaud Jannin Julien Bourry Gaetan Prévost Herve Lefebvre Marie-Christine Vantyghem |
author_sort |
Madleen Lemaitre |
title |
Rare Forms of Lipomatosis: Dercum’s Disease and Roch-Leri Mesosomatous Lipomatosis |
title_short |
Rare Forms of Lipomatosis: Dercum’s Disease and Roch-Leri Mesosomatous Lipomatosis |
title_full |
Rare Forms of Lipomatosis: Dercum’s Disease and Roch-Leri Mesosomatous Lipomatosis |
title_fullStr |
Rare Forms of Lipomatosis: Dercum’s Disease and Roch-Leri Mesosomatous Lipomatosis |
title_full_unstemmed |
Rare Forms of Lipomatosis: Dercum’s Disease and Roch-Leri Mesosomatous Lipomatosis |
title_sort |
rare forms of lipomatosis: dercum’s disease and roch-leri mesosomatous lipomatosis |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2021-03-01 |
description |
In contrast to obesity, which is very frequent, lipomatosis and lipodystrophy syndromes are rare diseases of adipose tissue. Lipodystrophy syndromes are characterized by metabolic abnormalities associated with partial or generalized lipoatrophy. Lipomatosis is defined by the presence of several body lipomas without lipoatrophy. Dercum’s disease (DD) and Roch-Leri mesosomatous lipomatosis (RLML) are rare and poorly characterized forms of lipomatosis. They have raised little clinical interest despite the non-negligible consequences of DD on quality of life. The main clinical presentation of these diseases includes multiple lipomas, which are painful in DD (in contrast to RLML). The two diseases are frequently associated with obesity and metabolic syndrome, with hypertension, diabetes, or dyslipidemia. The long-term course of the diseases remains poorly described. DD affects mainly women, whereas RLML mostly affects men. In both diseases lipomas are found on the back and thighs, as well as on the abdomen in DD and the forearms in RLML. The painful lipomas tend to recur after surgery in DD (in contrast to RLML). Most cases are sporadic. No specific treatment has been identified, as the pathophysiology remains unknown. Nevertheless, low-grade fat inflammation and specific abnormalities such as hyperbasophilia deserve further investigation. The aim of this review is to analyze the available literature on the topic. |
topic |
lipodystrophy Dercum’s disease Roch-Leri mesosomatous lipomatosis lipomatosis adipose tissue |
url |
https://www.mdpi.com/2077-0383/10/6/1292 |
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