Challenges in Conducting Studies in Chronic Graft-versus-Host Disease

Challenges in Conducting Studies in Chronic Graft-versus-Host Disease

The lack of standardized criteria for measuring therapeutic response has been a major obstacle to the development of therapeutic trials in chronic graft-versus-host disease (cGvHD). Nevertheless, recent advances have been made in understanding of the biology and pathophysiology of cGvHD, as well as...

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Bibliographic Details
Main Authors: Iskra Pusic, Steven Z. Pavletic
Format: Article
Language:English
Published: Atlantis Press 2019-03-01
Series:Clinical Hematology International
Subjects:
GvHD
GRFS
FFS
Response criteria
Composite endpoints
Online Access:https://www.atlantis-press.com/article/125905876/view
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spelling doaj-9af24f8668c546d4b230850627ccac132020-11-25T00:58:57ZengAtlantis PressClinical Hematology International2590-00482019-03-011110.2991/chi.d.190314.001Challenges in Conducting Studies in Chronic Graft-versus-Host DiseaseIskra PusicSteven Z. PavleticThe lack of standardized criteria for measuring therapeutic response has been a major obstacle to the development of therapeutic trials in chronic graft-versus-host disease (cGvHD). Nevertheless, recent advances have been made in understanding of the biology and pathophysiology of cGvHD, as well as establishing more precise criteria for the diagnosis and classification of disease manifestations. The momentum has shifted, and currently there is a long list of new potential treatment targets being identified for cGvHD. Consequently, new drugs are being implemented for its prophylaxis and treatment. It is crucial to continue that trend and develop better systems to test new drugs in clinical practice that would eventually translate toward seeking regulatory review and approval. We provide a historical perspective and current challenges in conducting cGvHD clinical trials.https://www.atlantis-press.com/article/125905876/viewGvHDGRFSFFSResponse criteriaComposite endpoints
collection DOAJ
language English
format Article
sources DOAJ
author Iskra Pusic
Steven Z. Pavletic
spellingShingle Iskra Pusic
Steven Z. Pavletic
Challenges in Conducting Studies in Chronic Graft-versus-Host Disease
Clinical Hematology International
GvHD
GRFS
FFS
Response criteria
Composite endpoints
author_facet Iskra Pusic
Steven Z. Pavletic
author_sort Iskra Pusic
title Challenges in Conducting Studies in Chronic Graft-versus-Host Disease
title_short Challenges in Conducting Studies in Chronic Graft-versus-Host Disease
title_full Challenges in Conducting Studies in Chronic Graft-versus-Host Disease
title_fullStr Challenges in Conducting Studies in Chronic Graft-versus-Host Disease
title_full_unstemmed Challenges in Conducting Studies in Chronic Graft-versus-Host Disease
title_sort challenges in conducting studies in chronic graft-versus-host disease
publisher Atlantis Press
series Clinical Hematology International
issn 2590-0048
publishDate 2019-03-01
description The lack of standardized criteria for measuring therapeutic response has been a major obstacle to the development of therapeutic trials in chronic graft-versus-host disease (cGvHD). Nevertheless, recent advances have been made in understanding of the biology and pathophysiology of cGvHD, as well as establishing more precise criteria for the diagnosis and classification of disease manifestations. The momentum has shifted, and currently there is a long list of new potential treatment targets being identified for cGvHD. Consequently, new drugs are being implemented for its prophylaxis and treatment. It is crucial to continue that trend and develop better systems to test new drugs in clinical practice that would eventually translate toward seeking regulatory review and approval. We provide a historical perspective and current challenges in conducting cGvHD clinical trials.
topic GvHD
GRFS
FFS
Response criteria
Composite endpoints
url https://www.atlantis-press.com/article/125905876/view
work_keys_str_mv AT iskrapusic challengesinconductingstudiesinchronicgraftversushostdisease
AT stevenzpavletic challengesinconductingstudiesinchronicgraftversushostdisease
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