Intensity-Modulated Radiation Therapy for Rectal Carcinoma Can Reduce Treatment Breaks and Emergency Department Visits
Purpose. To compare the acute toxicities of IMRT to 3D-conformal radiation therapy (3DCRT) in the treatment of rectal cancer. Methods and Materials. Eighty-six patients with rectal cancer preoperatively treated with IMRT (n=30) and 3DCRT (n=56) were retrospectively reviewed. Rates of acute toxicity...
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2012-01-01
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| Series: | International Journal of Surgical Oncology |
| Online Access: | http://dx.doi.org/10.1155/2012/891067 |
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doaj-9b066ea233cd4b21807fc6aa900225d6 |
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Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Salma K. Jabbour Shyamal Patel Joseph M. Herman Aaron Wild Suneel N. Nagda Taghrid Altoos Ahmet Tunceroglu Nilofer Azad Susan Gearheart Rebecca A. Moss Elizabeth Poplin Lydia L. Levinson Ravi A. Chandra Dirk F. Moore Chunxia Chen Bruce G. Haffty Richard Tuli |
| spellingShingle |
Salma K. Jabbour Shyamal Patel Joseph M. Herman Aaron Wild Suneel N. Nagda Taghrid Altoos Ahmet Tunceroglu Nilofer Azad Susan Gearheart Rebecca A. Moss Elizabeth Poplin Lydia L. Levinson Ravi A. Chandra Dirk F. Moore Chunxia Chen Bruce G. Haffty Richard Tuli Intensity-Modulated Radiation Therapy for Rectal Carcinoma Can Reduce Treatment Breaks and Emergency Department Visits International Journal of Surgical Oncology |
| author_facet |
Salma K. Jabbour Shyamal Patel Joseph M. Herman Aaron Wild Suneel N. Nagda Taghrid Altoos Ahmet Tunceroglu Nilofer Azad Susan Gearheart Rebecca A. Moss Elizabeth Poplin Lydia L. Levinson Ravi A. Chandra Dirk F. Moore Chunxia Chen Bruce G. Haffty Richard Tuli |
| author_sort |
Salma K. Jabbour |
| title |
Intensity-Modulated Radiation Therapy for Rectal Carcinoma Can Reduce Treatment Breaks and Emergency Department Visits |
| title_short |
Intensity-Modulated Radiation Therapy for Rectal Carcinoma Can Reduce Treatment Breaks and Emergency Department Visits |
| title_full |
Intensity-Modulated Radiation Therapy for Rectal Carcinoma Can Reduce Treatment Breaks and Emergency Department Visits |
| title_fullStr |
Intensity-Modulated Radiation Therapy for Rectal Carcinoma Can Reduce Treatment Breaks and Emergency Department Visits |
| title_full_unstemmed |
Intensity-Modulated Radiation Therapy for Rectal Carcinoma Can Reduce Treatment Breaks and Emergency Department Visits |
| title_sort |
intensity-modulated radiation therapy for rectal carcinoma can reduce treatment breaks and emergency department visits |
| publisher |
Hindawi Limited |
| series |
International Journal of Surgical Oncology |
| issn |
2090-1402 2090-1410 |
| publishDate |
2012-01-01 |
| description |
Purpose. To compare the acute toxicities of IMRT to 3D-conformal radiation therapy (3DCRT) in the treatment of rectal cancer. Methods and Materials. Eighty-six patients with rectal cancer preoperatively treated with IMRT (n=30) and 3DCRT (n=56) were retrospectively reviewed. Rates of acute toxicity between IMRT and 3DCRT were compared for anorexia, dehydration, diarrhea, nausea, vomiting, weight loss, radiation dermatitis, fatigue, pain, urinary frequency, and blood counts. Fisher's exact test and chi-square analysis were applied to detect statistical differences in incidences of toxicity between these two groups of patients. Results. There were fewer hospitalizations and emergency department visits in the group treated with IMRT compared with 3DCRT (P=0.005) and no treatment breaks with IMRT compared to 20% with 3DCRT (P=0.0002). Patients treated with IMRT had a significant reduction in grade ≥3 toxicities versus grade ≤2 toxicities (P=0.016) when compared to 3DCRT. The incidence of grade ≥3 diarrhea was 9% among 3DCRT patients compared to 3% among IMRT patients (P=0.31). Conclusions. IMRT for rectal cancer can reduce treatment breaks, emergency department visits, hospitalizations, and all grade ≥3 toxicities compared to 3DCRT. Further evaluation and followup is warranted to determine late toxicities and long-term results of IMRT. |
| url |
http://dx.doi.org/10.1155/2012/891067 |
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doaj-9b066ea233cd4b21807fc6aa900225d62020-11-24T23:20:08ZengHindawi LimitedInternational Journal of Surgical Oncology2090-14022090-14102012-01-01201210.1155/2012/891067891067Intensity-Modulated Radiation Therapy for Rectal Carcinoma Can Reduce Treatment Breaks and Emergency Department VisitsSalma K. Jabbour0Shyamal Patel1Joseph M. Herman2Aaron Wild3Suneel N. Nagda4Taghrid Altoos5Ahmet Tunceroglu6Nilofer Azad7Susan Gearheart8Rebecca A. Moss9Elizabeth Poplin10Lydia L. Levinson11Ravi A. Chandra12Dirk F. Moore13Chunxia Chen14Bruce G. Haffty15Richard Tuli16Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ-Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08903, USADepartment of Radiation Oncology, Albert Einstein Medical Center, New York, NY 10467, USADepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USADepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USADepartment of Radiation Oncology, Loyola University, Maywood, IL 60153, USADepartment of Radiation Oncology, Loyola University, Maywood, IL 60153, USADepartment of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ-Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08903, USADepartment of Medical Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USADepartment of Surgical Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USADivision of Medical Oncology, The Cancer Institute of New Jersey, UMDNJ-Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08903, USADivision of Medical Oncology, The Cancer Institute of New Jersey, UMDNJ-Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08903, USADepartment of Radiation Oncology, University of Virginia Medical Center, Charlottesville, VA 22908, USADepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USADepartment of Biostatistics, The Cancer Institute of New Jersey, UMDNJ-Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08903, USADepartment of Biostatistics, The Cancer Institute of New Jersey, UMDNJ-Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08903, USADepartment of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ-Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08903, USADepartment of Radiation Oncology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USAPurpose. To compare the acute toxicities of IMRT to 3D-conformal radiation therapy (3DCRT) in the treatment of rectal cancer. Methods and Materials. Eighty-six patients with rectal cancer preoperatively treated with IMRT (n=30) and 3DCRT (n=56) were retrospectively reviewed. Rates of acute toxicity between IMRT and 3DCRT were compared for anorexia, dehydration, diarrhea, nausea, vomiting, weight loss, radiation dermatitis, fatigue, pain, urinary frequency, and blood counts. Fisher's exact test and chi-square analysis were applied to detect statistical differences in incidences of toxicity between these two groups of patients. Results. There were fewer hospitalizations and emergency department visits in the group treated with IMRT compared with 3DCRT (P=0.005) and no treatment breaks with IMRT compared to 20% with 3DCRT (P=0.0002). Patients treated with IMRT had a significant reduction in grade ≥3 toxicities versus grade ≤2 toxicities (P=0.016) when compared to 3DCRT. The incidence of grade ≥3 diarrhea was 9% among 3DCRT patients compared to 3% among IMRT patients (P=0.31). Conclusions. IMRT for rectal cancer can reduce treatment breaks, emergency department visits, hospitalizations, and all grade ≥3 toxicities compared to 3DCRT. Further evaluation and followup is warranted to determine late toxicities and long-term results of IMRT.http://dx.doi.org/10.1155/2012/891067 |