Assessment of the muscle injury, inflammatory response and bone metabolism after paravertebral muscle space and minimally invasive percutaneous approach surgeries for thoracolumbar fracture
Objective: To study the muscle injury, inflammatory response and bone metabolism after paravertebral muscle space and minimally invasive percutaneous approach surgeries for thoracolumbar fracture. Methods: A total of 92 patients with thoracolumbar fractures who were treated in Baoji Central Hospi...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2017-08-01
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Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/201715/16.pdf |
Summary: | Objective: To study the muscle injury, inflammatory response and bone metabolism after
paravertebral muscle space and minimally invasive percutaneous approach surgeries for
thoracolumbar fracture. Methods: A total of 92 patients with thoracolumbar fractures who
were treated in Baoji Central Hospital between May 2015 and January 2017 were selected and
randomly divided into paravertebral group and minimally invasive percutaneous group who
accepted pedicle screw fixation under different approaches. Before operation as well as 1 d and
3 d after operation, serum was collected to determine the contents of creatase, inflammatory
reaction molecules and bone metabolism indexes. Results: Serum Myo, CK, LDH, TNF-α,
MCP-1, HMGB-1, CRP, IL-1β, OC, OPG, PICP and PINP levels of both groups 1 d and
3 d after operation were significantly higher than those before operation while TRACP5b,
RANKL, CTX and NTX levels were significantly lower than those before operation, and
serum Myo, CK, LDH, TNF-α, MCP-1, HMGB-1, CRP, IL-1β, TRACP5b, RANKL, CTX
and NTX levels of paravertebral group 1 d and 3 d after operation were significantly lower
than those of minimally invasive percutaneous group while OC, OPG, PICP and PINP levels
were significantly higher than those of minimally invasive percutaneous group. Conclusion:
Paravertebral muscle space surgery for thoracolumbar fracture is more effective than minimally
invasive percutaneous surgery in reducing muscle injury and inflammatory response, and
improving bone metabolism. |
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ISSN: | 1007-1237 1007-1237 |