Assessment of the muscle injury, inflammatory response and bone metabolism after paravertebral muscle space and minimally invasive percutaneous approach surgeries for thoracolumbar fracture
Objective: To study the muscle injury, inflammatory response and bone metabolism after paravertebral muscle space and minimally invasive percutaneous approach surgeries for thoracolumbar fracture. Methods: A total of 92 patients with thoracolumbar fractures who were treated in Baoji Central Hospi...
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doaj-9b07ca2523244e959d6d5493901d239a2020-11-25T00:28:57ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372017-08-0123156568Assessment of the muscle injury, inflammatory response and bone metabolism after paravertebral muscle space and minimally invasive percutaneous approach surgeries for thoracolumbar fractureJin Zhang0Qing She1Xin-Hu Wang2Baoji Central Hospital in Shaanxi Province, Baoji City, Shaanxi Province, 721008Baoji Central Hospital in Shaanxi Province, Baoji City, Shaanxi Province, 721008Baoji Central Hospital in Shaanxi Province, Baoji City, Shaanxi Province, 721008Objective: To study the muscle injury, inflammatory response and bone metabolism after paravertebral muscle space and minimally invasive percutaneous approach surgeries for thoracolumbar fracture. Methods: A total of 92 patients with thoracolumbar fractures who were treated in Baoji Central Hospital between May 2015 and January 2017 were selected and randomly divided into paravertebral group and minimally invasive percutaneous group who accepted pedicle screw fixation under different approaches. Before operation as well as 1 d and 3 d after operation, serum was collected to determine the contents of creatase, inflammatory reaction molecules and bone metabolism indexes. Results: Serum Myo, CK, LDH, TNF-α, MCP-1, HMGB-1, CRP, IL-1β, OC, OPG, PICP and PINP levels of both groups 1 d and 3 d after operation were significantly higher than those before operation while TRACP5b, RANKL, CTX and NTX levels were significantly lower than those before operation, and serum Myo, CK, LDH, TNF-α, MCP-1, HMGB-1, CRP, IL-1β, TRACP5b, RANKL, CTX and NTX levels of paravertebral group 1 d and 3 d after operation were significantly lower than those of minimally invasive percutaneous group while OC, OPG, PICP and PINP levels were significantly higher than those of minimally invasive percutaneous group. Conclusion: Paravertebral muscle space surgery for thoracolumbar fracture is more effective than minimally invasive percutaneous surgery in reducing muscle injury and inflammatory response, and improving bone metabolism.http://www.hnykdxxb.com/PDF/201715/16.pdfThoracolumbar fractureParavertebral muscle space approachMinimally invasive percutaneous approachInflammatory responseBone metabolism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jin Zhang Qing She Xin-Hu Wang |
spellingShingle |
Jin Zhang Qing She Xin-Hu Wang Assessment of the muscle injury, inflammatory response and bone metabolism after paravertebral muscle space and minimally invasive percutaneous approach surgeries for thoracolumbar fracture Journal of Hainan Medical University Thoracolumbar fracture Paravertebral muscle space approach Minimally invasive percutaneous approach Inflammatory response Bone metabolism |
author_facet |
Jin Zhang Qing She Xin-Hu Wang |
author_sort |
Jin Zhang |
title |
Assessment of the muscle injury, inflammatory response and bone metabolism after paravertebral muscle space and minimally invasive percutaneous approach surgeries for thoracolumbar fracture |
title_short |
Assessment of the muscle injury, inflammatory response and bone metabolism after paravertebral muscle space and minimally invasive percutaneous approach surgeries for thoracolumbar fracture |
title_full |
Assessment of the muscle injury, inflammatory response and bone metabolism after paravertebral muscle space and minimally invasive percutaneous approach surgeries for thoracolumbar fracture |
title_fullStr |
Assessment of the muscle injury, inflammatory response and bone metabolism after paravertebral muscle space and minimally invasive percutaneous approach surgeries for thoracolumbar fracture |
title_full_unstemmed |
Assessment of the muscle injury, inflammatory response and bone metabolism after paravertebral muscle space and minimally invasive percutaneous approach surgeries for thoracolumbar fracture |
title_sort |
assessment of the muscle injury, inflammatory response and bone metabolism after paravertebral muscle space and minimally invasive percutaneous approach surgeries for thoracolumbar fracture |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2017-08-01 |
description |
Objective: To study the muscle injury, inflammatory response and bone metabolism after
paravertebral muscle space and minimally invasive percutaneous approach surgeries for
thoracolumbar fracture. Methods: A total of 92 patients with thoracolumbar fractures who
were treated in Baoji Central Hospital between May 2015 and January 2017 were selected and
randomly divided into paravertebral group and minimally invasive percutaneous group who
accepted pedicle screw fixation under different approaches. Before operation as well as 1 d and
3 d after operation, serum was collected to determine the contents of creatase, inflammatory
reaction molecules and bone metabolism indexes. Results: Serum Myo, CK, LDH, TNF-α,
MCP-1, HMGB-1, CRP, IL-1β, OC, OPG, PICP and PINP levels of both groups 1 d and
3 d after operation were significantly higher than those before operation while TRACP5b,
RANKL, CTX and NTX levels were significantly lower than those before operation, and
serum Myo, CK, LDH, TNF-α, MCP-1, HMGB-1, CRP, IL-1β, TRACP5b, RANKL, CTX
and NTX levels of paravertebral group 1 d and 3 d after operation were significantly lower
than those of minimally invasive percutaneous group while OC, OPG, PICP and PINP levels
were significantly higher than those of minimally invasive percutaneous group. Conclusion:
Paravertebral muscle space surgery for thoracolumbar fracture is more effective than minimally
invasive percutaneous surgery in reducing muscle injury and inflammatory response, and
improving bone metabolism. |
topic |
Thoracolumbar fracture Paravertebral muscle space approach Minimally invasive percutaneous approach Inflammatory response Bone metabolism |
url |
http://www.hnykdxxb.com/PDF/201715/16.pdf |
work_keys_str_mv |
AT jinzhang assessmentofthemuscleinjuryinflammatoryresponseandbonemetabolismafterparavertebralmusclespaceandminimallyinvasivepercutaneousapproachsurgeriesforthoracolumbarfracture AT qingshe assessmentofthemuscleinjuryinflammatoryresponseandbonemetabolismafterparavertebralmusclespaceandminimallyinvasivepercutaneousapproachsurgeriesforthoracolumbarfracture AT xinhuwang assessmentofthemuscleinjuryinflammatoryresponseandbonemetabolismafterparavertebralmusclespaceandminimallyinvasivepercutaneousapproachsurgeriesforthoracolumbarfracture |
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1725333506112880640 |