Usefulness of Noninvasive Predictors of Oesophageal Varices in Black African Cirrhotic Patients in Côte d'Ivoire (West Africa)
Aims. To determine the usefulness of platelet count (PC), spleen diameter (SD) and platelet count/spleen diameter ratio (PC/SD ratio) for the prediction of oesophageal varices (OV) and large OV in black African patients with cirrhosis in Côte d’Ivoire. Materials and Methods. Study was conducted in a...
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2012-01-01
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doaj-9b121ca14a1b4b4ea8a0be2c2238f17c2020-11-24T21:24:42ZengHindawi LimitedGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/216390216390Usefulness of Noninvasive Predictors of Oesophageal Varices in Black African Cirrhotic Patients in Côte d'Ivoire (West Africa)Alassan Kouamé Mahassadi0Fulgence Yao Bathaix1Constant Assi2Aboubacar Demba Bangoura3Emile Allah-Kouadio4Henriette Ya Kissi5Abdoulaye Touré6Stanislas Doffou7Issa Konaté8Alain Koffi Attia9Mathieu Benoit Camara10Thérèse Aya Ndri-Yoman11Service d’Hépato-Gastroentérologie, CHU de Yopougon, 21 BP 632 Abidjan 21, Cote d'IvoireService d’Hépato-Gastroentérologie, CHU de Yopougon, 21 BP 632 Abidjan 21, Cote d'IvoireService d’Hépato-Gastroentérologie, CHU de Cocody, Abidjan, Cote d'IvoireService d’Hépato-Gastroentérologie, CHU de Yopougon, 21 BP 632 Abidjan 21, Cote d'IvoireService d’Hépato-Gastroentérologie, CHU de Cocody, Abidjan, Cote d'IvoireService d’Hépato-Gastroentérologie, CHU de Yopougon, 21 BP 632 Abidjan 21, Cote d'IvoireService d’Imagérie Médicale, CHU de Yopougon, Abidjan, Cote d'IvoireService d’Hépato-Gastroentérologie, CHU de Yopougon, 21 BP 632 Abidjan 21, Cote d'IvoireService d’Imagérie Médicale, CHU de Cocody, Abidjan, Cote d'IvoireService d’Hépato-Gastroentérologie, CHU de Yopougon, 21 BP 632 Abidjan 21, Cote d'IvoireService d’Hépato-Gastroentérologie, CHU de Cocody, Abidjan, Cote d'IvoireService d’Hépato-Gastroentérologie, CHU de Yopougon, 21 BP 632 Abidjan 21, Cote d'IvoireAims. To determine the usefulness of platelet count (PC), spleen diameter (SD) and platelet count/spleen diameter ratio (PC/SD ratio) for the prediction of oesophageal varices (OV) and large OV in black African patients with cirrhosis in Côte d’Ivoire. Materials and Methods. Study was conducted in a training sample (111 patients) and in a validation sample (91 patients). Results. Factors predicting OV were sex: (OR=0.08, P=0.0003), PC (OR = 12.4, P=0.0003), SD (OR = 1.04, P=0.002) in the training sample. The AUROCs (±SE) of the model (cutoff ≥ 0.6), PC (cutoff < 110500), SD (cutoff > 140) and PC/SD ratio (cutoff ≤ 868) were, respectively; 0.879 ± 0.04, 0.768 ± 0.06, 0.679 ± 0.06, 0.793 ± 0.06. For the prediction of large OV, the model’s AUROC (0.850 ± 0.05) was superior to that of PC (0.688 ± 0.06), SD (0.732 ± 0.05) and PC/SD ratio (0.752 ± 0.06). In the validation sample, with PC, PC/SD ratio and the model, upper digestive endoscopy could be obviated respectively in 45.1, 45.1, and 44% of cirrhotic patients. Prophylactic treatment with beta blockers could be started undoubtedly respectively in 36.3, 41.8 and 28.6% of them as having large OV. Conclusion. Non-invasive means could be used to monitor cirrhotic patients and consider treatment in African regions lacking endoscopic facilities.http://dx.doi.org/10.1155/2012/216390 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alassan Kouamé Mahassadi Fulgence Yao Bathaix Constant Assi Aboubacar Demba Bangoura Emile Allah-Kouadio Henriette Ya Kissi Abdoulaye Touré Stanislas Doffou Issa Konaté Alain Koffi Attia Mathieu Benoit Camara Thérèse Aya Ndri-Yoman |
spellingShingle |
Alassan Kouamé Mahassadi Fulgence Yao Bathaix Constant Assi Aboubacar Demba Bangoura Emile Allah-Kouadio Henriette Ya Kissi Abdoulaye Touré Stanislas Doffou Issa Konaté Alain Koffi Attia Mathieu Benoit Camara Thérèse Aya Ndri-Yoman Usefulness of Noninvasive Predictors of Oesophageal Varices in Black African Cirrhotic Patients in Côte d'Ivoire (West Africa) Gastroenterology Research and Practice |
author_facet |
Alassan Kouamé Mahassadi Fulgence Yao Bathaix Constant Assi Aboubacar Demba Bangoura Emile Allah-Kouadio Henriette Ya Kissi Abdoulaye Touré Stanislas Doffou Issa Konaté Alain Koffi Attia Mathieu Benoit Camara Thérèse Aya Ndri-Yoman |
author_sort |
Alassan Kouamé Mahassadi |
title |
Usefulness of Noninvasive Predictors of Oesophageal Varices in Black African Cirrhotic Patients in Côte d'Ivoire (West Africa) |
title_short |
Usefulness of Noninvasive Predictors of Oesophageal Varices in Black African Cirrhotic Patients in Côte d'Ivoire (West Africa) |
title_full |
Usefulness of Noninvasive Predictors of Oesophageal Varices in Black African Cirrhotic Patients in Côte d'Ivoire (West Africa) |
title_fullStr |
Usefulness of Noninvasive Predictors of Oesophageal Varices in Black African Cirrhotic Patients in Côte d'Ivoire (West Africa) |
title_full_unstemmed |
Usefulness of Noninvasive Predictors of Oesophageal Varices in Black African Cirrhotic Patients in Côte d'Ivoire (West Africa) |
title_sort |
usefulness of noninvasive predictors of oesophageal varices in black african cirrhotic patients in côte d'ivoire (west africa) |
publisher |
Hindawi Limited |
series |
Gastroenterology Research and Practice |
issn |
1687-6121 1687-630X |
publishDate |
2012-01-01 |
description |
Aims. To determine the usefulness of platelet count (PC), spleen diameter (SD) and platelet count/spleen diameter ratio (PC/SD ratio) for the prediction of oesophageal varices (OV) and large OV in black African patients with cirrhosis in Côte d’Ivoire. Materials and Methods. Study was conducted in a training sample (111 patients) and in a validation sample (91 patients). Results. Factors predicting OV were sex: (OR=0.08, P=0.0003), PC (OR = 12.4, P=0.0003), SD (OR = 1.04, P=0.002) in the training sample. The AUROCs (±SE) of the model (cutoff ≥ 0.6), PC (cutoff < 110500), SD (cutoff > 140) and PC/SD ratio (cutoff ≤ 868) were, respectively; 0.879 ± 0.04, 0.768 ± 0.06, 0.679 ± 0.06, 0.793 ± 0.06. For the prediction of large OV, the model’s AUROC (0.850 ± 0.05) was superior to that of PC (0.688 ± 0.06), SD (0.732 ± 0.05) and PC/SD ratio (0.752 ± 0.06). In the validation sample, with PC, PC/SD ratio and the model, upper digestive endoscopy could be obviated respectively in 45.1, 45.1, and 44% of cirrhotic patients. Prophylactic treatment with beta blockers could be started undoubtedly respectively in 36.3, 41.8 and 28.6% of them as having large OV. Conclusion. Non-invasive means could be used to monitor cirrhotic patients and consider treatment in African regions lacking endoscopic facilities. |
url |
http://dx.doi.org/10.1155/2012/216390 |
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