PHARMACOECONOMIC ANALYSIS OF EFFICACY OF DIFFERENT MODES OF ANTIBIOTIC PROPHYLAXIS IN CHOLECYSTECTOMY

• Main Authors: A. N. Poborskiy, N. I. Ponamarev, Sh. D. Asutaev
• Format: Article
• Language: Russian
• Published: Pavlov First Saint Petersburg State Medical University 2016-10-01
• Series: Вестник хирургии имени И.И. Грекова
• Subjects: cholecystectomy; antibiotic prophylaxis; pharmacoeconomic analysis
• Online Access: https://www.vestnik-grekova.ru/jour/article/view/354

Pharmacoeconomic assessment of efficacy of different modes of antibiotic prophylaxis was made in 27 patients with diagnosis of acute calculous cholecystitis using method of «cost-efficacy». Patients have taken ampicillin/sulbactam intravenously in the dose of 1,5 g or cephazolin intravenously in the dose 2,0 g. Medicine should be taken in 30 min. before the operation. The most expensive was antibiotic prophylaxis by cephazolin. The coefficient of «cost-efficacy» was 774,2 rubles on 1 unit of efficacy in case of cephazolin and it was 506,1 rubles on 1 unit of efficacy in other group with antibiotic prophylaxis by ampicillin/sulbactam. The authors noted the economical and clinical advantage of antibiotic prophylaxis by ampicillin /sulbactam.