Two New Withanolide Lactones from Flos Daturae

• Main Authors: Yong-Gang Xia, Qiu-Hong Wang, Bing-You Yang, Hai-Xue Kuang
• Format: Article
• Language: English
• Published: MDPI AG 2011-07-01
• Series: Molecules
• Subjects: Flos Daturae; Datura metel L.; withanolide lactones
• Online Access: http://www.mdpi.com/1420-3049/16/7/5833/

Chemical investigation of the 50% ethanol eluate fraction from a macroporous resin of flowers of Datura metel L. collected in the Jiangsu Province of China resulted in the isolation of two new withanolides, baimantuoluoline G (1) and baimantuoluoside H (2). Their structures were elucidated as (12β,6β,22R)-1,10-seco-6,12,27-trihydroxy-26-oxo-witha-3,5,24-trienolide-1-oic acid-ε-lactone (1) and (5β,6α,12β,22R)-5,6,12,27-tetra-hydroxy-1,26-dioxo-witha-2,24-dienolide-27-O-β-glucopyranoside (2) on the basis of extensive spectroscopic analysis (1D, 2D-NMR and HRESIMS) and chemical studies.