Difference in ultrasonic strain ratio between benign and malignant thyroid nodules and its correlation with cell apoptosis and invasion
Objective: To study the difference in ultrasonic strain ratio between benign and malignant thyroid nodules and its correlation with cell apoptosis and invasion. Methods: A total of 130 patients diagnosed with thyroid nodules by ultrasonography in our hospital between April 2014 and April 2016 wer...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2016-11-01
|
Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/201621/23.pdf |
Summary: | Objective: To study the difference in ultrasonic strain ratio between benign and malignant
thyroid nodules and its correlation with cell apoptosis and invasion. Methods: A total of 130
patients diagnosed with thyroid nodules by ultrasonography in our hospital between April 2014
and April 2016 were selected, and the pathological results were referred to distinguish between
benign and malignant nodules. Thyroid ultrasonic elastography was performed to determine
strain ratio (S/R), and thyroid biopsy tissue or surgically removed tissue was collected to
determine the content of apoptosis and invasion-related molecules. Results: S/R of malignant
thyroid nodules was significantly higher than that of benign nodules; Wip1, Livin, MMP1,
MMP9, TCF and β-catenin content in malignant thyroid nodules were significantly higher
than those in benign nodules while CCNG2, PPZA2, Caspase9, Kiss-1 and GPR54 content
were significantly lower than those in benign nodules; Wip1, Livin, MMP1, MMP9, TCF and
β-catenin content in malignant thyroid nodules with high S/R were significantly higher than
those in nodules with low S/R while CCNG2, PPZA2, Caspase9, Kiss-1 and GPR54 content
were significantly lower than those in nodules with low S/R. Conclusions: Ultrasound S/R of
malignant thyroid nodules is significantly higher than that of benign nodules and the higher the
S/R, the more exuberant the cell proliferation and invasion in malignant nodule tissue. |
---|---|
ISSN: | 1007-1237 1007-1237 |