Association of Early and Late Contrast-Associated Acute Kidney Injury and Long-Term Mortality in Patients Undergoing Coronary Angiography
Background. Contrast-associated acute kidney injury (CA-AKI) is a common complication in patients undergoing coronary angiography (CAG). However, few studies demonstrate the association between the prognosis and developed CA-AKI in the different periods after the operation. Methods. We retrospective...
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doaj-9b4dcd71b5fc4edc8339abffc71389672021-03-22T00:03:21ZengHindawi-WileyJournal of Interventional Cardiology1540-81832021-01-01202110.1155/2021/6641887Association of Early and Late Contrast-Associated Acute Kidney Injury and Long-Term Mortality in Patients Undergoing Coronary AngiographyZhubin Lun0Jin Liu1Liwei Liu2Jingjing Liang3Guanzhong Chen4Shiqun Chen5Bo Wang6Qiang Li7Haozhang Huang8Zhidong Huang9Danyuan Xu10Yunzhao Hu11Ning Tan12Jiyan Chen13Yong Liu14Jianfeng Ye15Department of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyBackground. Contrast-associated acute kidney injury (CA-AKI) is a common complication in patients undergoing coronary angiography (CAG). However, few studies demonstrate the association between the prognosis and developed CA-AKI in the different periods after the operation. Methods. We retrospectively enrolled 3206 patients with preoperative serum creatinine (Scr) and at least twice SCr measurement after CAG. CA-AKI was defined as an increase ≥50% or ≥0.3 mg/dL from baseline in the 72 hours after the procedure. Early CA-AKI was defined as having the first increase in SCr within the early phase (<24 hours), and late CA-AKI was defined as an increase in SCr that occurred for the first time in the late phase (24–72 hours). The first endpoint of this study was long-term all-cause mortality. Kaplan–Meier analysis was used to count the cumulative mortality, and the log-rank test was used to assess differences between curves. Univariate and multivariate cox regression analyses were performed to assess whether patients who developed different type CA-AKI were at increased risk of long-term mortality. Results. The number of deaths in the 3 groups was 407 for normal (12.7%), 106 for early CA-AKI (32.7%) and 57 for late CA-AKI (17.7%), during a median follow-up period of 3.95 years. After adjusting for important clinical variables, early CA-AKI (HR = 1.33, 95% CI: 1.02–1.74, P=0.038) was significantly associated with mortality, while late CA-AKI (HR = 0.92, 95% CI: 0.65–1.31, P=0.633) was not. The same results were found in patients with coronary artery disease, chronic kidney disease, diabetes mellitus, and percutaneous coronary intervention. Conclusions. Early increases in Scr, i.e., early CA-AKI, have better predictive value for long-term mortality. Therefore, in clinical practice, physicians should pay more attention to patients with early renal injury related to long-term prognosis and give active treatment.http://dx.doi.org/10.1155/2021/6641887 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhubin Lun Jin Liu Liwei Liu Jingjing Liang Guanzhong Chen Shiqun Chen Bo Wang Qiang Li Haozhang Huang Zhidong Huang Danyuan Xu Yunzhao Hu Ning Tan Jiyan Chen Yong Liu Jianfeng Ye |
spellingShingle |
Zhubin Lun Jin Liu Liwei Liu Jingjing Liang Guanzhong Chen Shiqun Chen Bo Wang Qiang Li Haozhang Huang Zhidong Huang Danyuan Xu Yunzhao Hu Ning Tan Jiyan Chen Yong Liu Jianfeng Ye Association of Early and Late Contrast-Associated Acute Kidney Injury and Long-Term Mortality in Patients Undergoing Coronary Angiography Journal of Interventional Cardiology |
author_facet |
Zhubin Lun Jin Liu Liwei Liu Jingjing Liang Guanzhong Chen Shiqun Chen Bo Wang Qiang Li Haozhang Huang Zhidong Huang Danyuan Xu Yunzhao Hu Ning Tan Jiyan Chen Yong Liu Jianfeng Ye |
author_sort |
Zhubin Lun |
title |
Association of Early and Late Contrast-Associated Acute Kidney Injury and Long-Term Mortality in Patients Undergoing Coronary Angiography |
title_short |
Association of Early and Late Contrast-Associated Acute Kidney Injury and Long-Term Mortality in Patients Undergoing Coronary Angiography |
title_full |
Association of Early and Late Contrast-Associated Acute Kidney Injury and Long-Term Mortality in Patients Undergoing Coronary Angiography |
title_fullStr |
Association of Early and Late Contrast-Associated Acute Kidney Injury and Long-Term Mortality in Patients Undergoing Coronary Angiography |
title_full_unstemmed |
Association of Early and Late Contrast-Associated Acute Kidney Injury and Long-Term Mortality in Patients Undergoing Coronary Angiography |
title_sort |
association of early and late contrast-associated acute kidney injury and long-term mortality in patients undergoing coronary angiography |
publisher |
Hindawi-Wiley |
series |
Journal of Interventional Cardiology |
issn |
1540-8183 |
publishDate |
2021-01-01 |
description |
Background. Contrast-associated acute kidney injury (CA-AKI) is a common complication in patients undergoing coronary angiography (CAG). However, few studies demonstrate the association between the prognosis and developed CA-AKI in the different periods after the operation. Methods. We retrospectively enrolled 3206 patients with preoperative serum creatinine (Scr) and at least twice SCr measurement after CAG. CA-AKI was defined as an increase ≥50% or ≥0.3 mg/dL from baseline in the 72 hours after the procedure. Early CA-AKI was defined as having the first increase in SCr within the early phase (<24 hours), and late CA-AKI was defined as an increase in SCr that occurred for the first time in the late phase (24–72 hours). The first endpoint of this study was long-term all-cause mortality. Kaplan–Meier analysis was used to count the cumulative mortality, and the log-rank test was used to assess differences between curves. Univariate and multivariate cox regression analyses were performed to assess whether patients who developed different type CA-AKI were at increased risk of long-term mortality. Results. The number of deaths in the 3 groups was 407 for normal (12.7%), 106 for early CA-AKI (32.7%) and 57 for late CA-AKI (17.7%), during a median follow-up period of 3.95 years. After adjusting for important clinical variables, early CA-AKI (HR = 1.33, 95% CI: 1.02–1.74, P=0.038) was significantly associated with mortality, while late CA-AKI (HR = 0.92, 95% CI: 0.65–1.31, P=0.633) was not. The same results were found in patients with coronary artery disease, chronic kidney disease, diabetes mellitus, and percutaneous coronary intervention. Conclusions. Early increases in Scr, i.e., early CA-AKI, have better predictive value for long-term mortality. Therefore, in clinical practice, physicians should pay more attention to patients with early renal injury related to long-term prognosis and give active treatment. |
url |
http://dx.doi.org/10.1155/2021/6641887 |
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