Engineering Cytoplasmic Signaling of CD28ζ CARs for Improved Therapeutic Functions

Engineering Cytoplasmic Signaling of CD28ζ CARs for Improved Therapeutic Functions

Chimeric antigen receptor modified T cells (CAR-T) have yielded impressive clinical outcomes in treating hematopoietic malignancies. However, relapses have occurred in a substantial number of patients and limited the development of CAR-T therapy. Most underlying reasons for these relapses can be att...

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Bibliographic Details
Main Authors: Xianhui Meng, Ruirui Jing, Liling Qian, Chun Zhou, Jie Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
chimeric antigen receptor
CD3ζ
ITAM
signal strength
cytotoxicity
persistence
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01046/full

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