Effect of 0.5g/L cyclosporine A for symptom and sign scores in patients with moderate to severe dry eye

• Main Authors: Su-Ying Yu, Cheng-Rong Fu
• Format: Article
• Language: English
• Published: Press of International Journal of Ophthalmology (IJO PRESS) 2016-05-01
• Series: Guoji Yanke Zazhi
• Subjects: cyclosporine A eye drops; dry eye syndrome; symptom score
• Online Access: http://ies.ijo.cn/cn_publish/2016/5/201605032.pdf

AIM:To investigate the effect of 0.5g/L cyclosporine A for symptom and sign scores in patients with moderate to severe dry eye.<p>METHODS:Eighty patients(160 eyes)with moderate to severe dry eye were divided into two groups by double-blind and random principles:40 patients(80 eyes)in observation group were treated with 10g/L sodium carboxymethyl cellulose and 0.5g/L cyclosporine A eye drops, 40 patients(80 eyes)in the control group were treated with 10g/L sodium carboxymethyl cellulose eye drops. The changes of ocular sign and symptom scores were compared between the two groups.<p>RESULTS:The total effective rate of observation group was 95.0%, which was significantly higher than that of control group(85.0%, <i>P</i><0.05). Symptom scores before treatment in observation group and the control group were 36.1±4.4 and 36.4±4.5 points, respectively; symptom scores at 1 and 3mo after treatment were 25.2±3.2, 11.09±3.9 points in observation group, 29.4±4.1, 22.05±3.1 points in control group. The differences of the two groups before and after treatment were statistically significantly(<i>P</i><0.05). The scores of observation group at 1 and 3mo after treatment were lower than those of control group(<i>P</i><0.05). Before treatment, break-up time(BUT), Schirmer I test(SⅠt), fluorescein staining(FL)and ocular surface disease index(OSDI)scores had no significant differences between the two groups(<i>P</i>>0.05). After treatment, the four parameters of observation group were improved significantly(<i>P</i><0.05), while only FL and OSDI of control group were improved(<i>P</i><0.05). The four parameters of observation group were higher than those of control group(<i>P</i><0.05).Three eyes in observation group felt tingling during 14-28d of the drug using, 2 eyes in control group felt tingling and one eye in control group had conjunctival congestion. All the symptoms disappeared after 2d without stopping the drugs. <p>CONCLUSION:The 0.5g/L cyclosporine A eye drops can effectively relieve the symptoms and signs of moderate to severe dry eye, promote tear secretion, and improve ocular surface environment. The treatment effect is good.