Focal 123I-FP-CIT SPECT Abnormality in Midbrain Vascular Parkinsonism

Focal 123I-FP-CIT SPECT Abnormality in Midbrain Vascular Parkinsonism

Cerebrovascular diseases are considered among possible causes of acute/subacute parkinsonism, representing up to 22% of secondary movement disorders. In cases of suspected vascular parkinsonism (VP), dopamine transporter SPECT has been highly recommended to exclude nigrostriatal dopaminergic degener...

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Main Authors: Paolo Solla, Antonino Cannas, Roberta Arca, Davide Fonti, Gianni Orofino, Francesco Marrosu
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Case Reports in Neurological Medicine
Online Access:http://dx.doi.org/10.1155/2015/642764
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spelling doaj-9b7b594b655940a0a4fb1197437093962020-11-24T22:28:20ZengHindawi LimitedCase Reports in Neurological Medicine2090-66682090-66762015-01-01201510.1155/2015/642764642764Focal 123I-FP-CIT SPECT Abnormality in Midbrain Vascular ParkinsonismPaolo Solla0Antonino Cannas1Roberta Arca2Davide Fonti3Gianni Orofino4Francesco Marrosu5Movement Disorders Center, Department of Neurology, Institute of Neurology, University of Cagliari, Monserrato, 09042 Cagliari, ItalyMovement Disorders Center, Department of Neurology, Institute of Neurology, University of Cagliari, Monserrato, 09042 Cagliari, ItalyMovement Disorders Center, Department of Neurology, Institute of Neurology, University of Cagliari, Monserrato, 09042 Cagliari, ItalyMovement Disorders Center, Department of Neurology, Institute of Neurology, University of Cagliari, Monserrato, 09042 Cagliari, ItalyMovement Disorders Center, Department of Neurology, Institute of Neurology, University of Cagliari, Monserrato, 09042 Cagliari, ItalyMovement Disorders Center, Department of Neurology, Institute of Neurology, University of Cagliari, Monserrato, 09042 Cagliari, ItalyCerebrovascular diseases are considered among possible causes of acute/subacute parkinsonism, representing up to 22% of secondary movement disorders. In cases of suspected vascular parkinsonism (VP), dopamine transporter SPECT has been highly recommended to exclude nigrostriatal dopaminergic degeneration. We report the case of a hemiparkinsonism related to a left midbrain infarct with focal lateralized putaminal abnormalities at 123I-FP-CIT SPECT imaging. The asymmetric uptake at dopamine transporter SPECT was different to findings commonly observed in typical PD pattern, because the ipsilateral striatum, in opposite to idiopathic PD, showed normal tracer binding. However, this selective parkinsonism after infarction of the midbrain was responsive to levodopa. In conclusion, we retain that there is a need of more functional imaging studies in VP addressed to a more consistent classification of its different clinical forms and to a better understanding of the adequate pharmacological management.http://dx.doi.org/10.1155/2015/642764
collection DOAJ
language English
format Article
sources DOAJ
author Paolo Solla
Antonino Cannas
Roberta Arca
Davide Fonti
Gianni Orofino
Francesco Marrosu
spellingShingle Paolo Solla
Antonino Cannas
Roberta Arca
Davide Fonti
Gianni Orofino
Francesco Marrosu
Focal 123I-FP-CIT SPECT Abnormality in Midbrain Vascular Parkinsonism
Case Reports in Neurological Medicine
author_facet Paolo Solla
Antonino Cannas
Roberta Arca
Davide Fonti
Gianni Orofino
Francesco Marrosu
author_sort Paolo Solla
title Focal 123I-FP-CIT SPECT Abnormality in Midbrain Vascular Parkinsonism
title_short Focal 123I-FP-CIT SPECT Abnormality in Midbrain Vascular Parkinsonism
title_full Focal 123I-FP-CIT SPECT Abnormality in Midbrain Vascular Parkinsonism
title_fullStr Focal 123I-FP-CIT SPECT Abnormality in Midbrain Vascular Parkinsonism
title_full_unstemmed Focal 123I-FP-CIT SPECT Abnormality in Midbrain Vascular Parkinsonism
title_sort focal 123i-fp-cit spect abnormality in midbrain vascular parkinsonism
publisher Hindawi Limited
series Case Reports in Neurological Medicine
issn 2090-6668
2090-6676
publishDate 2015-01-01
description Cerebrovascular diseases are considered among possible causes of acute/subacute parkinsonism, representing up to 22% of secondary movement disorders. In cases of suspected vascular parkinsonism (VP), dopamine transporter SPECT has been highly recommended to exclude nigrostriatal dopaminergic degeneration. We report the case of a hemiparkinsonism related to a left midbrain infarct with focal lateralized putaminal abnormalities at 123I-FP-CIT SPECT imaging. The asymmetric uptake at dopamine transporter SPECT was different to findings commonly observed in typical PD pattern, because the ipsilateral striatum, in opposite to idiopathic PD, showed normal tracer binding. However, this selective parkinsonism after infarction of the midbrain was responsive to levodopa. In conclusion, we retain that there is a need of more functional imaging studies in VP addressed to a more consistent classification of its different clinical forms and to a better understanding of the adequate pharmacological management.
url http://dx.doi.org/10.1155/2015/642764
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AT davidefonti focal123ifpcitspectabnormalityinmidbrainvascularparkinsonism
AT gianniorofino focal123ifpcitspectabnormalityinmidbrainvascularparkinsonism
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