Moxibustion for treating cancer‐related fatigue: A multicenter, assessor‐blinded, randomized controlled clinical trial
Abstract Cancer‐related fatigue (CRF) is one of the most common chronic symptoms experienced by cancer patients. As moxibustion is a popular traditional therapy for managing fatigue, it can be an alternative strategy to treat CRF as well. Therefore, we rigorously designed a full‐scale, multicenter,...
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doaj-9b7ec7882ee14683af66c6508bfbc3092021-07-20T08:11:37ZengWileyCancer Medicine2045-76342021-07-0110144721473310.1002/cam4.4020Moxibustion for treating cancer‐related fatigue: A multicenter, assessor‐blinded, randomized controlled clinical trialKyungsun Han0Mikyung Kim1Eun‐Jung Kim2Yeon‐Cheol Park3Ojin Kwon4Ae‐Ran Kim5Hyo‐Ju Park6Yang‐Chun Park7Jung Hyo Cho8Joo‐Hee Kim9Jun‐Hwan Lee10Clinical Medicine Division Korea Institute of Oriental Medicine Daejeon Republic of KoreaDepartment of Internal Medicine, College of Korean Medicine Sangji University Wonju Republic of KoreaDepartment of Acupuncture and Moxibustion Medicine, College of Korean Medicine Dongguk University Gyeongju Republic of KoreaDepartment of Acupuncture and Moxibustion Medicine Kyung Hee University Hospital at Gangdong Seoul Republic of KoreaClinical Medicine Division Korea Institute of Oriental Medicine Daejeon Republic of KoreaClinical Medicine Division Korea Institute of Oriental Medicine Daejeon Republic of KoreaClinical Medicine Division Korea Institute of Oriental Medicine Daejeon Republic of KoreaDepartment of Internal Medicine, College of Korean Medicine Daejeon University Daejeon Republic of KoreaDepartment of Internal Medicine, College of Korean Medicine Daejeon University Daejeon Republic of KoreaDepartment of Acupuncture and Moxibustion Medicine, College of Korean Medicine Sangji University Gangwon‐do Republic of KoreaClinical Medicine Division Korea Institute of Oriental Medicine Daejeon Republic of KoreaAbstract Cancer‐related fatigue (CRF) is one of the most common chronic symptoms experienced by cancer patients. As moxibustion is a popular traditional therapy for managing fatigue, it can be an alternative strategy to treat CRF as well. Therefore, we rigorously designed a full‐scale, multicenter, assessor‐blinded, randomized controlled trial to evaluate the efficacy and safety of moxibustion treatment for CRF. Ninety‐six subjects suffering from CRF were recruited and randomly assigned to moxibustion group, sham moxibustion group, or usual care group. Both the moxibustion group and the sham group received moxibustion treatment for 8 weeks and the usual care group did not. Brief fatigue inventory (BFI) score and Functional Assessment of Cancer Therapy‐Fatigue score were used to assess CRF at baseline and weeks 5, 9, and 13. Questionnaires for the assessment of cognitive impairment, quality of life, and Cold–Heat and Deficiency–Excess patterns were also evaluated. BFI scores significantly decreased in moxibustion group compared to the usual care group (mean difference of −1.92, p < 0.001 at week 9 and mean difference of −2.36, p < 0.001 at week 13). Although the sham group also showed significant improvement during the treatment period, only the moxibustion group showed improvement after 4 weeks of follow‐up period (mean difference of −1.06, p < 0.001). There were no serious adverse events. Our findings confirmed the efficacy and safety of moxibustion for CRF compared to usual care. We also found that moxibustion has a prolonged treatment effect during 4 weeks of follow‐up period.https://doi.org/10.1002/cam4.4020cancer‐related fatigueclinical managementintegrative medicinemoxibustionquality of liferandomized controlled trial |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kyungsun Han Mikyung Kim Eun‐Jung Kim Yeon‐Cheol Park Ojin Kwon Ae‐Ran Kim Hyo‐Ju Park Yang‐Chun Park Jung Hyo Cho Joo‐Hee Kim Jun‐Hwan Lee |
spellingShingle |
Kyungsun Han Mikyung Kim Eun‐Jung Kim Yeon‐Cheol Park Ojin Kwon Ae‐Ran Kim Hyo‐Ju Park Yang‐Chun Park Jung Hyo Cho Joo‐Hee Kim Jun‐Hwan Lee Moxibustion for treating cancer‐related fatigue: A multicenter, assessor‐blinded, randomized controlled clinical trial Cancer Medicine cancer‐related fatigue clinical management integrative medicine moxibustion quality of life randomized controlled trial |
author_facet |
Kyungsun Han Mikyung Kim Eun‐Jung Kim Yeon‐Cheol Park Ojin Kwon Ae‐Ran Kim Hyo‐Ju Park Yang‐Chun Park Jung Hyo Cho Joo‐Hee Kim Jun‐Hwan Lee |
author_sort |
Kyungsun Han |
title |
Moxibustion for treating cancer‐related fatigue: A multicenter, assessor‐blinded, randomized controlled clinical trial |
title_short |
Moxibustion for treating cancer‐related fatigue: A multicenter, assessor‐blinded, randomized controlled clinical trial |
title_full |
Moxibustion for treating cancer‐related fatigue: A multicenter, assessor‐blinded, randomized controlled clinical trial |
title_fullStr |
Moxibustion for treating cancer‐related fatigue: A multicenter, assessor‐blinded, randomized controlled clinical trial |
title_full_unstemmed |
Moxibustion for treating cancer‐related fatigue: A multicenter, assessor‐blinded, randomized controlled clinical trial |
title_sort |
moxibustion for treating cancer‐related fatigue: a multicenter, assessor‐blinded, randomized controlled clinical trial |
publisher |
Wiley |
series |
Cancer Medicine |
issn |
2045-7634 |
publishDate |
2021-07-01 |
description |
Abstract Cancer‐related fatigue (CRF) is one of the most common chronic symptoms experienced by cancer patients. As moxibustion is a popular traditional therapy for managing fatigue, it can be an alternative strategy to treat CRF as well. Therefore, we rigorously designed a full‐scale, multicenter, assessor‐blinded, randomized controlled trial to evaluate the efficacy and safety of moxibustion treatment for CRF. Ninety‐six subjects suffering from CRF were recruited and randomly assigned to moxibustion group, sham moxibustion group, or usual care group. Both the moxibustion group and the sham group received moxibustion treatment for 8 weeks and the usual care group did not. Brief fatigue inventory (BFI) score and Functional Assessment of Cancer Therapy‐Fatigue score were used to assess CRF at baseline and weeks 5, 9, and 13. Questionnaires for the assessment of cognitive impairment, quality of life, and Cold–Heat and Deficiency–Excess patterns were also evaluated. BFI scores significantly decreased in moxibustion group compared to the usual care group (mean difference of −1.92, p < 0.001 at week 9 and mean difference of −2.36, p < 0.001 at week 13). Although the sham group also showed significant improvement during the treatment period, only the moxibustion group showed improvement after 4 weeks of follow‐up period (mean difference of −1.06, p < 0.001). There were no serious adverse events. Our findings confirmed the efficacy and safety of moxibustion for CRF compared to usual care. We also found that moxibustion has a prolonged treatment effect during 4 weeks of follow‐up period. |
topic |
cancer‐related fatigue clinical management integrative medicine moxibustion quality of life randomized controlled trial |
url |
https://doi.org/10.1002/cam4.4020 |
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